{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:40:54Z","timestamp":1777927254374,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"20","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:p>\n                    Breath-by-breath oxygen-carbon dioxide (O\n                    <jats:sub>2<\/jats:sub>\n                    -CO\n                    <jats:sub>2)<\/jats:sub>\n                    exchange ratio (bER) is a respiratory gas exchange (RGE) metric, which is the ratio of the changes in the partial pressure of O\n                    <jats:sub>2<\/jats:sub>\n                    (\u0394PO\n                    <jats:sub>2<\/jats:sub>\n                    ) to CO\n                    <jats:sub>2<\/jats:sub>\n                    (\u0394PCO\n                    <jats:sub>2<\/jats:sub>\n                    ) between end-inspiration and end-expiration, has been demonstrated to characterize the cerebrovascular responses to breath-hold challenge in healthy individuals. We aimed to explore whether bER could characterize cerebrovascular responses in patients with chronic mild traumatic brain injury (mTBI) under breath-hold challenge. We also investigated the correlation between bER and the severity of post-concussion symptoms. Blood-oxygenation-level-dependent (BOLD) images were acquired using functional magnetic resonance imaging (fMRI) on 10 patients with chronic mTBI and 10 controls without brain injury history when performing a breath-hold task. Time series of RGE metrics of \u0394PO\n                    <jats:sub>2<\/jats:sub>\n                    , \u0394PCO\n                    <jats:sub>2<\/jats:sub>\n                    , and bER were computed, and their cross-correlation with regional change in BOLD (\u0394BOLD) was calculated. Symptom burden was assessed using the Rivermead Post Concussion Questionnaire (RPQ), and its correlation with RGE changes was also measured. Compared with controls, a diffuse decrease in the correlation between regional \u0394BOLD and bER was found in the brain of patients with mTBI (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    <jats:sub>fdr<\/jats:sub>\n                    &lt; 0.05). No significant difference was found between patients and controls for the correlation of regional \u0394BOLD with \u0394PO\n                    <jats:sub>2<\/jats:sub>\n                    and \u0394PCO\n                    <jats:sub>2<\/jats:sub>\n                    . Symptom severity indicated by RPQ scores increased with a decrease in the averaged changes of bER (\n                    <jats:italic toggle=\"yes\">\u03c1<\/jats:italic>\n                    \u2009=\u20090.79,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.01) and \u0394PO\n                    <jats:sub>2<\/jats:sub>\n                    (\n                    <jats:italic toggle=\"yes\">\u03c1<\/jats:italic>\n                    \u2009=\u20090.70,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.03) in breath-hold epochs. Our imaging and symptom severity findings suggest that bER can be used to characterize cerebrovascular responses to breath hold in patients with mTBI. The RGE may contribute to the post-concussive symptom severity.\n                  <\/jats:p>","DOI":"10.1089\/neu.2021.0166","type":"journal-article","created":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T00:38:17Z","timestamp":1625186297000},"page":"2851-2861","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Cerebrovascular Responses to O\n                    <sub>2<\/sub>\n                    -CO\n                    <sub>2<\/sub>\n                    Exchange Ratio under Brief Breath-Hold Challenge in Patients with Chronic Mild Traumatic Brain Injury"],"prefix":"10.1177","volume":"38","author":[{"given":"Suk-Tak","family":"Chan","sequence":"first","affiliation":[{"name":"Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cora","family":"Ordway","sequence":"additional","affiliation":[{"name":"Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald J.","family":"Calvanio","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferdinando S.","family":"Buonanno","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce R.","family":"Rosen","sequence":"additional","affiliation":[{"name":"Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth K.","family":"Kwong","sequence":"additional","affiliation":[{"name":"Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,10,12]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30415-0"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/09540260310001606692"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2015.05.019"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aem131"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.31.4.299"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2017.5114"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.3171\/2015.6.JNS15972"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X19896883"},{"key":"e_1_3_6_10_2","first-page":"1233","article-title":"Cerebral blood flow-related signal changes during breath-holding","volume":"20","author":"Kastrup A.","year":"1999","unstructured":"Kastrup A., , Li T.Q., , Glover G.H., , and Moseley M.E. 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