{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:10:21Z","timestamp":1787008221683,"version":"build-2736575974"},"reference-count":70,"publisher":"SAGE Publications","issue":"23","license":[{"start":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T00:00:00Z","timestamp":1637625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:p>Traumatic brain injury (TBI) is a risk factor for later-life dementia. Clinical and pre-clinical studies have elucidated multiple mechanisms through which TBI may influence or exacerbate multiple pathological processes underlying Alzheimer's disease and Alzheimer's disease\u2013related dementias (AD\/ADRD). The National Institutes of Health hosts triennial ADRD Summits to inform a national research agenda, and the 2019 ADRD Summit was the first to highlight \u201cTBI and AD\/ADRD Risk\u201d as an emerging topic in the field. A multidisciplinary committee of TBI researchers with relevant expertise reviewed extant literature, identified research gaps and opportunities, and proposed draft research recommendations at the 2019 ADRD Summit. These research recommendations, further refined after broad stakeholder input at the Summit, cover four overall areas: 1) Encourage crosstalk and interdisciplinary collaboration between TBI and dementia researchers; 2) Establish infrastructure to study TBI as a risk factor for AD\/ADRD; 3) Promote basic and clinical research examining the development and progression of TBI AD\/ADRD neuropathologies and associated clinical symptoms; and 4) Characterize the clinical phenotype of progressive dementia associated with TBI and develop non-invasive diagnostic approaches. These recommendations recognize a need to strengthen communication and build frameworks to connect the complexity of TBI with rapidly evolving AD\/ADRD research. Recommendations acknowledge TBI as a clinically and pathologically heterogeneous disease whose associations with AD\/ADRDs remain incompletely understood. The recommendations highlight the scientific advantage of investigating AD\/ADRD in the context of a known TBI exposure, the study of which can directly inform on disease mechanisms and treatment targets for AD\/ADRDs with shared common pathways.<\/jats:p>","DOI":"10.1089\/neu.2021.0216","type":"journal-article","created":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T10:33:10Z","timestamp":1635503590000},"page":"3186-3194","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Alzheimer's Disease-Related Dementias Summit 2019: National Research Priorities for the Investigation of Traumatic Brain Injury as a Risk Factor for Alzheimer's Disease and Related Dementias"],"prefix":"10.1177","volume":"38","author":[{"given":"Kristen","family":"Dams-O'Connor","sequence":"first","affiliation":[{"name":"Department of Rehabilitation and Human Performance, Icahn School of Medicine at Mount Sinai, New York, New York, USA."},{"name":"Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick S.F.","family":"Bellgowan","sequence":"additional","affiliation":[{"name":"National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roderick","family":"Corriveau","sequence":"additional","affiliation":[{"name":"National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Jo","family":"Pugh","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA."},{"name":"VA Salt Lake City Health Care System, Salt Lake City, Utah, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas H.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Pennsylvania, Philadelphia Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Pathology, Rush University Medical Center, Chicago, Illinois, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Whitaker","sequence":"additional","affiliation":[{"name":"National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, M\u00f6lndal, Sweden."},{"name":"Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, M\u00f6lndal, Sweden."},{"name":"Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, United Kingdom."},{"name":"UK Dementia Research Institute at UCL, London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,11,23]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/20.Supplement_2.S28"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.0815"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(18)30065-8"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/1010539516662956"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.8.1158"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.3171\/2015.2.JNS14503"},{"key":"e_1_3_2_8_2","article-title":"Head injury as a risk factor for dementia and Alzheimer's disease: a systematic review and meta-analysis of 32 observational studies","volume":"12","author":"Li Y.","year":"2017","unstructured":"Li Y., , Li Y., , Li X., , Zhang S., , Zhao J., , Zhu X., , and Tian G. (2017). Head injury as a risk factor for dementia and Alzheimer's disease: a systematic review and meta-analysis of 32 observational studies. PloS One, 12, e0169650.","journal-title":"PloS One"},{"key":"e_1_3_2_9_2","volume-title":"Gulf War and Health: Volume 7: Long-Term Consequences of Traumatic Brain Injury","author":"Institute of Medicine","year":"2009","unstructured":"Institute of Medicine. (2009). Gulf War and Health: Volume 7: Long-Term Consequences of Traumatic Brain Injury. National Academies Press: Washington, DC."},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2012-303938"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.1948"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30279-X"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.2217\/nmt-2016-0017"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.1.78"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12080"},{"key":"e_1_3_2_16_2","article-title":"Traumatic brain injury and risk of neurodegenerative disorder","author":"Brett B.L.","year":"2021","unstructured":"Brett B.L., , Gardner R.C., , Godbout J., , Dams-O'Connor, and K., , Keene C.D. (2021). Traumatic brain injury and risk of neurodegenerative disorder. Biol. Psychiatry 2021 Jun 2; Epub ahead of print.","journal-title":"Biol. Psychiatry"},{"key":"e_1_3_2_17_2","first-page":"print","article-title":"Phenotyping the spectrum of traumatic brain injury: a review and pathway to standardization","author":"Pugh M.J.","year":"2021","unstructured":"Pugh M.J., , Kennedy E., , Prager E.M., , Humpherys J., , Dams-O'Connor K., , Hack D., , McCafferty M.K., , Wolfe J., , Yaffe K., , McCrea M., , Ferguson A.R., , Lancashire L., , Ghajar J., , and Lumba-Brown A. (2021). Phenotyping the spectrum of traumatic brain injury: a review and pathway to standardization. J. Neurotrauma 2021 Jun 10; Epub ahead of print.","journal-title":"J. Neurotrauma"},{"key":"e_1_3_2_18_2","unstructured":"Alzheimer's Association. (2021). 2021 Alzheimer's disease facts and figures."},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1159\/000455127"},{"key":"e_1_3_2_20_2","unstructured":"World Health Organization. (2020). Dementia. www.who.int\/news-room\/fact-sheets\/detail\/dementia (Last accessed May28 2021)."},{"key":"e_1_3_2_21_2","first-page":"361","article-title":"Nat","volume":"11","author":"Johnson V.E.","year":"2010","unstructured":"Johnson V.E., , Stewart W., , and Smith D.H., Traumatic brain injury and amyloid-\u03b2 pathology: a link to Alzheimer's disease? (2010). Nat. Rev. Neurosci. 11, 361\u2013370.","journal-title":"Rev. Neurosci"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-57193-5_15"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-017-0088-2"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws322"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2018.01.021"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2017.5457"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlx101"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.624696"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e3181ee7d85"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2013.29"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-018-0114-8"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000733"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004717"},{"key":"e_1_3_2_34_2","unstructured":"Holtzman D.M. and Corriveau R.A. (2016). ADRD Summit 2016 Report to the National Advisory Neurological Disorders and Stroke Council. https:\/\/aspe.hhs.gov\/collaborations-committees-advisory-groups\/napa\/napa-additional-information\/additional-council-associated-resources-information\/adrd-summit-2016-report (Last accessed November3 2021)."},{"key":"e_1_3_2_35_2","unstructured":"Schneider J.A. Jeon S. Gladman J.T. and Corriveau R.A. (2019). ADRD Summit 2019 Report to the National Advisory Neurological Disorders and Stroke Council. www.ninds.nih.gov\/sites\/default\/files\/2019_adrd_summit_recommendations_508c.pdf (Last accessed November3 2021)."},{"key":"e_1_3_2_36_2","article-title":"Increased risk of dementia in patients with mild traumatic brain injury: a nationwide cohort study","volume":"8","author":"Lee Y.K.","year":"2013","unstructured":"Lee Y.K., , Hou S.W., , Lee C.C., , Hsu C.Y., , Huang Y.S., , and Su Y.C. (2013). Increased risk of dementia in patients with mild traumatic brain injury: a nationwide cohort study. PloS One. 8, e62422.","journal-title":"PloS One"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(18)30065-8"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000616"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1159\/000369787"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1080\/13854046.2019.1679889"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002496"},{"key":"e_1_3_2_42_2","first-page":"10","article-title":"Assessing the severity of traumatic brain injury-time for a change?","author":"Tenovuo O.","year":"2021","unstructured":"Tenovuo O., , Diaz-Arrastia. R., Goldstein L.E., , Sharp D.J., , van der Naalt, . J., and Zasler N.D. (2021). Assessing the severity of traumatic brain injury-time for a change?. J. Clin. Med. 10.","journal-title":"J. Clin. Med"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2013.01.023"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000194264.60150.d3"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001199-200108000-00005"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2008.07.004"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/acz074"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.3233\/NRE-130838"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2012.2638"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2018.6346"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2013.06.036"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-011-0909-9"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.12.015"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.8334"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-015-0148-8"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1097\/HTR.0000000000000454"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2013.2970"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1713632"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-015-1435-y"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2019.6375"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2018.12.042"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2019.6375"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2018.12.042"},{"key":"e_1_3_2_64_2","doi-asserted-by":"crossref","unstructured":"(2021). Time Course and Diagnostic Utility of Nfl Tau GFAP and UCH-L1 in Subacute and Chronic TBI. Neurology 96 593.","DOI":"10.1212\/WNL.0000000000011717"},{"key":"e_1_3_2_65_2","unstructured":"Glasgow Brain Injury Research Group. (2021). Glasgow Traumatic Brain Injury Archive. https:\/\/gbirg.inp.gla.ac.uk\/glasgow-traumatic-brain-injury-archive (Last accessed May28 2021)."},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-021-00872-x"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1097\/HTR.0000000000000514"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2013.08.297"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1017\/S135561771300146X"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlab001"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000011850"}],"container-title":["Journal of Neurotrauma"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/neu.2021.0216","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/neu.2021.0216","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/neu.2021.0216","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:39:12Z","timestamp":1777675152000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/neu.2021.0216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,23]]},"references-count":70,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1089\/neu.2021.0216"],"URL":"https:\/\/doi.org\/10.1089\/neu.2021.0216","relation":{},"ISSN":["0897-7151","1557-9042"],"issn-type":[{"value":"0897-7151","type":"print"},{"value":"1557-9042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,23]]}}}