{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:58:16Z","timestamp":1791979096831,"version":"4.4.0"},"reference-count":42,"publisher":"SAGE Publications","issue":"3-4","license":[{"start":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T00:00:00Z","timestamp":1642723200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:p>\n                    Degenerative cervical myelopathy (DCM) is hallmarked by spinal canal narrowing and related cord compression and myelopathy. Cerebrospinal fluid (CSF) pressure dynamics are likely disturbed due to spinal canal stenosis. The study aimed to investigate the diagnostic value of continuous intraoperative CSF pressure monitoring during surgical decompression. This prospective single center study (NCT02170155) enrolled DCM patients who underwent surgical decompression between December 2019 and May 2021. Data from\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200917 patients were analyzed and symptom severity graded with the modified Japanese Orthopedic Score (mJOA). CSF pulsations were continuously monitored with a lumbar intrathecal catheter during surgical decompression. Mean patient age was 62\u2009\u00b1\u20099 years (range 38-73; 8 female), symptoms were mild-moderate in most patients (mean mJOA 14\u2009\u00b1\u20092, range 10-18). Measurements were well tolerated without safety concerns. In 15\/16 patients (94%), CSF pulsations increased at the time of surgical decompression. In one case, responsiveness could not be evaluated for technical reasons. Unexpected CSF pulsation decrease was related to adverse events (i.e., CSF leakage). Median CSF pulsation amplitudes increased from pre-decompression (0.52\u2009mm Hg, interquartile range [IQR] 0.71) to post-decompression (0.72\u2009mm Hg, IQR 0.96;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.001). Mean baseline CSF pressure increased with lower magnitude than pulsations, from 9.5\u2009\u00b1\u20093.5 to 10.3\u2009\u00b1\u20093.8\u2009mm Hg (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.003). Systematic relations of CSF pulsations were confined to surgical decompression, independent of arterial blood pressure (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.927) or heart rate (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.102). Intraoperative CSF pulsation monitoring was related to surgical decompression while in addition adverse events could be discerned. Further investigation of the clinical value of intraoperative guidance for decompression in complex DCM surgery is promising.\n                  <\/jats:p>","DOI":"10.1089\/neu.2021.0310","type":"journal-article","created":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T09:55:00Z","timestamp":1637574900000},"page":"300-310","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Intraoperative Monitoring of CSF Pressure in Patients with Degenerative Cervical Myelopathy (COMP-CORD Study): A Prospective Cohort Study"],"prefix":"10.1177","volume":"39","author":[{"given":"Carl M.","family":"Zipser","sequence":"first","affiliation":[{"name":"Spinal Cord Injury Center, Balgrist University Hospital, Zurich, Switzerland."},{"name":"University Spine Center, Balgrist University Hospital, Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolai","family":"Pfender","sequence":"additional","affiliation":[{"name":"Spinal Cord Injury Center, Balgrist University Hospital, Zurich, Switzerland."},{"name":"University Spine Center, Balgrist University Hospital, Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najmeh","family":"Kheram","sequence":"additional","affiliation":[{"name":"Spinal Cord Injury Center, Balgrist University Hospital, Zurich, Switzerland."},{"name":"Institute of Physiology, University of Zurich, Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Boraschi","sequence":"additional","affiliation":[{"name":"Institute of Physiology, University of Zurich, Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Aguirre","sequence":"additional","affiliation":[{"name":"University Spine Center, Balgrist University Hospital, Zurich, Switzerland."},{"name":"Department of Anesthesiology, Balgrist University Hospital, Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils H.","family":"Ulrich","sequence":"additional","affiliation":[{"name":"University Spine Center, Balgrist University Hospital, Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Miguel","family":"Spirig","sequence":"additional","affiliation":[{"name":"University Spine Center, Balgrist University Hospital, Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Ansorge","sequence":"additional","affiliation":[{"name":"University Spine Center, Balgrist University Hospital, Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Betz","sequence":"additional","affiliation":[{"name":"University Spine Center, Balgrist University Hospital, Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Wanivenhaus","sequence":"additional","affiliation":[{"name":"University Spine Center, Balgrist University Hospital, Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Hupp","sequence":"additional","affiliation":[{"name":"Spinal Cord Injury Center, Balgrist University Hospital, Zurich, Switzerland."},{"name":"University Spine Center, Balgrist University Hospital, Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vartan","family":"Kurtcuoglu","sequence":"additional","affiliation":[{"name":"Institute of Physiology, University of Zurich, Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mazda","family":"Farshad","sequence":"additional","affiliation":[{"name":"University Spine Center, Balgrist University Hospital, Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Curt","sequence":"additional","affiliation":[{"name":"Spinal Cord Injury Center, Balgrist University Hospital, Zurich, Switzerland."},{"name":"University Spine Center, Balgrist University Hospital, Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Schubert","sequence":"additional","affiliation":[{"name":"Spinal Cord Injury Center, Balgrist University Hospital, Zurich, Switzerland."},{"name":"University Spine Center, Balgrist University Hospital, Zurich, 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