{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T14:43:51Z","timestamp":1789829031738,"version":"4.0.1"},"reference-count":66,"publisher":"SAGE Publications","issue":"9-10","license":[{"start":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T00:00:00Z","timestamp":1650412800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:p>\n                    When the blood\u2013spinal cord barrier (BSCB) is disrupted after a spinal cord injury (SCI), several pathophysiological cascades occur, including inflammation and apoptotic cell death of neurons and oligodendrocytes, resulting in permanent neurological deficits. Transient receptor potential melastatin 7 (TRPM7) is involved in the pathological processes in many neuronal diseases, including traumatic brain injury, amyotrophic lateral sclerosis, parkinsonism dementia, and Alzheimer's disease. Further, carvacrol (CAR), a TRPM7 inhibitor, is known to protect against SCI by reducing oxidative stress and inhibiting the endothelial nitric oxide synthase pathway. However, the functions of TRPM7 in the regulation of BSCB homeostasis after SCI have not been examined. Here, we demonstrated that TRPM7, a calcium-mediated non-selective divalent cation channel, plays a critical role after SCI in rats. Rats were contused at T9 and given CAR (50\u2009mg\/kg) intraperitoneally immediately and 12\u2009h after SCI, and then given the same dose once a day for 7 days. TRPM7 was found to be up-regulated after SCI in both\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    studies, and it was expressed in blood vessels alongside neurons and oligodendrocytes. Additionally, CAR treatment suppressed BSCB disruption by inhibiting the loss of tight junction (TJ) proteins and preserved TJ integrity. CAR also reduced apoptotic cell death and improved functional recovery after SCI by preventing BSCB disruption caused by blood infiltration and inflammatory responses. Based on these findings, we propose that blocking the TRPM7 channel can inhibit the destruction of the BSCB and it is a potential target in therapeutic drug development for use in SCI.\n                  <\/jats:p>","DOI":"10.1089\/neu.2021.0338","type":"journal-article","created":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T12:02:25Z","timestamp":1645012945000},"page":"735-749","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Suppression of Transient Receptor Potential Melastatin 7 by Carvacrol Protects against Injured Spinal Cord by Inhibiting Blood\u2013Spinal Cord Barrier Disruption"],"prefix":"10.1177","volume":"39","author":[{"given":"Chan Sol","family":"Park","sequence":"first","affiliation":[{"name":"Age-Related and Brain Diseases Research Center, School of Medicine, Kyung Hee University, Seoul, Korea."},{"name":"Department of Biomedical Science, School of Medicine, Kyung Hee University, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jee Youn","family":"Lee","sequence":"additional","affiliation":[{"name":"Age-Related and Brain Diseases Research Center, School of Medicine, Kyung Hee University, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hae Young","family":"Choi","sequence":"additional","affiliation":[{"name":"Age-Related and Brain Diseases Research Center, School of Medicine, Kyung Hee University, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Young","family":"Yune","sequence":"additional","affiliation":[{"name":"Age-Related and Brain Diseases Research Center, School of Medicine, Kyung Hee University, Seoul, Korea."},{"name":"Department of Biomedical Science, School of Medicine, Kyung Hee University, Seoul, Korea."},{"name":"Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,4,20]]},"reference":[{"key":"e_1_3_4_2_2","first-page":"FL","article-title":"Spinal cord injuries, in: StatPearls","author":"Bennett J.","year":"2020","unstructured":"Bennett J., , Das J.M., , and Emmady P.D. 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