{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:10:51Z","timestamp":1787008251572,"version":"build-2736575974"},"reference-count":57,"publisher":"SAGE Publications","issue":"7-8","license":[{"start":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T00:00:00Z","timestamp":1647993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:p>\n                    Repetitive head impact (RHI) exposure has been associated with differences in brain structure among younger active athletes, most often within the hippocampus. Studies of former athletes at early-midlife are limited. We investigated the association between RHI exposure and gray matter (GM) structure, as well as moderating factors, among former athletes in early-midlife. Former collegiate football players (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200955; age\u2009=\u200937.9\n                    <jats:underline>+<\/jats:underline>\n                    1.5 years) completed magnetic resonance imaging to quantify GM morphometry and extensive structured interviews of RHI history (Head Impact Exposure Estimate). Linear regression models tested the association between RHI exposure and GM structures of interest. Interactions were tested for moderators: two estimates of intelligence quotient (IQ) (single word reading and picture vocabulary) and education history. Greater RHI exposure was associated with smaller hippocampal volume, \u03b2\u2009=\u2009-0.36,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.004. Conversely, RHI exposure was not significantly associated with other GM outcomes\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    s\u2009&gt;\u20090.05. Education history significantly moderated the association between RHI exposure and hippocampal volume, \u03b2\u2009=\u20090.31,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.047. Among those with a bachelor's degree, greater RHI exposure was significantly associated with smaller hippocampal volumes, \u03b2\u2009=\u2009-0.58,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001. For those with graduate\/professional degrees, the association between RHI and hippocampal volume was not significant, \u03b2\u2009=\u2009-0.33,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.134. Consistent with studies involving younger, active athletes, smaller hippocampal volumes were selectively associated with greater RHI exposure among former collegiate football players at midlife. This relationship was moderated by higher levels of education. Future longitudinal studies are needed to investigate the course of possible changes that can occur between early-midlife and older ages, as well as the continued protective effect of education and other potential influential factors.\n                  <\/jats:p>","DOI":"10.1089\/neu.2021.0449","type":"journal-article","created":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T09:48:54Z","timestamp":1642585734000},"page":"497-507","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Head Impact Exposure, Gray Matter Volume, and Moderating Effects of Estimated Intelligence Quotient and Educational Attainment in Former Athletes at Midlife"],"prefix":"10.1177","volume":"39","author":[{"given":"Benjamin L.","family":"Brett","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin, USA."},{"name":"Department of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel R.","family":"Walton","sequence":"additional","affiliation":[{"name":"Department of Exercise and Sport Science and University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy B.","family":"Meier","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew S.","family":"Nencka","sequence":"additional","affiliation":[{"name":"Department of Radiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA."},{"name":"Department of Center for Imaging Research, Medical College of Wisconsin, Milwaukee, Wisconsin, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob R.","family":"Powell","sequence":"additional","affiliation":[{"name":"Department of Exercise and Sport Science and University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly S.","family":"Giovanello","sequence":"additional","affiliation":[{"name":"Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA."},{"name":"Department of Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin M.","family":"Guskiewicz","sequence":"additional","affiliation":[{"name":"Department of Exercise and Sport Science and University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"McCrea","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin, USA."},{"name":"Department of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,3,23]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nec.2016.05.009"},{"issue":"10","key":"e_1_3_6_3_2","first-page":"56","article-title":"White matter signal abnormalities in former National Football League players","author":"Alosco M.L.","year":"2018","unstructured":"Alosco M.L., , Koerte I.K., , Tripodis Y., , Mariani M., , Chua A.S., , Jarnagin J., , Rahimpour Y., , Puzo C., , Healy R.C., , Martin B., , Chaisson C.E., , Cantu R.C., , Au R., , McClean M., , McKee A.C., , Lin A.P., , Shenton M.E., , Killiany R.J., , and Stern R.A. 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