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Despite widespread reports that cardioendocrine disorders are more prevalent in individuals with SCI than those without disability, a well-defined pathophysiology has not been established. Autonomic dysfunction accompanying disruption of autonomic spinal tracts may contribute to dysregulation of energy metabolism via uncoupling of integrated hunger and satiation signals. In governing human feeding behaviors, these signals are controlled by a network of enteroendocrine cells that line the gastrointestinal (GI) tract. These cells regulate GI peptide release and autonomic systems that maintain direct neuroendocrine communication between the GI tract and appetite circuitry of the hypothalamus and brainstem. Here we investigate gene-expression and physiological changes in GI peptides and hormones, as well as changes in physiological response to feeding, glucose and insulin challenge, and evaluate GI tissue cytoarchitecture after experimental SCI. Adult female mice (C57BL\/6) were subjected to a severe SCI (65 kDyne) at T9, and a sham control group received laminectomy only. The SCI results in chronic elevation of fasting plasma glucose levels and an exaggerated glucose response after an oral glucose and insulin tolerance test. Mice with SCI also exhibit significant alteration in gut hormone genes, plasma levels, physiological response to prandial challenge, and cell loss and gross tissue damage in the gut. These findings demonstrate that SCI has widespread effects on the GI system contributing to component cardiometabolic disease risk factors and may inform future therapeutic and rehabilitation strategies in humans.<\/jats:p>","DOI":"10.1089\/neu.2021.0490","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T15:12:18Z","timestamp":1664377938000},"page":"981-998","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Characterization of Gastrointestinal Hormone Dysfunction and Metabolic Pathophysiology in Experimental Spinal Cord Injury"],"prefix":"10.1177","volume":"40","author":[{"given":"Gregory E.","family":"Bigford","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery and the Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Szeto","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology, Diabetes and Metabolism and The Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, Florida, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Darr","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Education, University of Illinois College of Medicine at Peoria, Peoria, Illinois, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Placido","family":"Illiano","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery and the Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Zambrano","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, New York University Langone Health, New York, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando J.","family":"Mendez","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology, Diabetes and Metabolism and The Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, Florida, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S.","family":"Nash","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery and the Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, USA."},{"name":"Department of Physical Medicine and Rehabilitation, University of Miami Miller School of Medicine, Miami, Florida, USA."},{"name":"Department of Physical Therapy, University of Miami, Miami, Florida, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,4,28]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.sc.3101729"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0b013e31802f0247"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2007.02.031"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.2340\/16501977-0658"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1310\/sci1204-1"},{"key":"e_1_3_5_7_2","first-page":"333","article-title":"injury","volume":"2007","author":"Gater DR","unstructured":"Gater DRJr. Obesity after spinal cord injury. 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