{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T12:06:05Z","timestamp":1789733165874,"version":"4.0.1"},"reference-count":66,"publisher":"SAGE Publications","issue":"11-12","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:p>\n                    The consequences of forceful rotational acceleration on the central nervous system are not fully understood. While traumatic brain injury (TBI) research primarily has focused on effects related to the brain parenchyma, reports of traumatic meningeal enhancement in TBI patients may possess clinical significance. The objective of this study was to evaluate the meninges and brain for changes in dynamic contrast enhancement (DCE) magnetic resonance imaging (MRI) following closed-head impact model of engineered rotational acceleration (CHIMERA)\u2013induced cerebral insult. Adult male and female mice received one (1\u2009\u00d7\u2009;\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200919 CHIMERA,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200919 Sham) or four (4\u2009\u00d7\u2009one\/day;\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200918 CHIMERA,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200912 Sham) injuries. Each animal underwent three MRI scans: 1 week before injury, immediately after the final injury, and 1 week post-injury. Compared with baseline readings and measures in sham animals, meningeal DCE in males was increased after single impact and repetitive injury. In female mice, DCE was elevated relative to their baseline level after a single impact. One week after CHIMERA, the meningeal enhancement returned to below baseline for single injured male mice, but compared with uninjured mice remained elevated in both sexes in the multiple impact groups. Pre-DCE meningeal T2-weighted relaxation time was increased only after 1\u2009\u00d7\u2009CHIMERA in injured mice. Since vision is impaired after CHIMERA, visual pathway regions were analyzed through imaging and glial fibrillary acidic protein (GFAP) histology. Initial DCE in the lateral geniculate nucleus (LGN) and superior colliculus (SC) and T2 increases in the optic tract (OPT) and LGN were observed after injury with decreases in DCE and T2 1 week later. Astrogliosis was apparent in the OPT and SC with increased GFAP staining 7 days post-injury. To our knowledge, this is the first study to examine meningeal integrity after CHIMERA in both male and female rodents. DCE-MRI may serve as a useful approach for pre-clinical models of meningeal injury that will enable further evaluation of the underlying mechanisms.\n                  <\/jats:p>","DOI":"10.1089\/neu.2021.0494","type":"journal-article","created":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T05:20:56Z","timestamp":1646371256000},"page":"784-799","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Meningeal and Visual Pathway Magnetic Resonance Imaging Analysis after Single and Repetitive Closed-Head Impact Model of Engineered Rotational Acceleration (CHIMERA)-Induced Disruption in Male and Female Mice"],"prefix":"10.1177","volume":"39","author":[{"given":"Eileen H.","family":"McNamara","sequence":"first","affiliation":[{"name":"Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Knutsen","sequence":"additional","affiliation":[{"name":"Center for Neuroscience and Regenerative Medicine, Henry M. Jackson Foundation, Bethesda, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandru","family":"Korotcov","sequence":"additional","affiliation":[{"name":"Center for Neuroscience and Regenerative Medicine, Henry M. Jackson Foundation, Bethesda, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asamoah","family":"Bosomtwi","sequence":"additional","affiliation":[{"name":"Center for Neuroscience and Regenerative Medicine, Henry M. Jackson Foundation, Bethesda, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda H.","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA."},{"name":"Department of Anatomy, Physiology and Genetics, Pre-Clinical Behavior and Modeling Core, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Kostelnik","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antigone A.","family":"Grillakis","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haley","family":"Spencer","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Dardzinski","sequence":"additional","affiliation":[{"name":"Center for Neuroscience and Regenerative Medicine, Henry M. Jackson Foundation, Bethesda, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph T.","family":"McCabe","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA."},{"name":"Department of Anatomy, Physiology and Genetics, Pre-Clinical Behavior and Modeling Core, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,6,3]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.3233\/NRE-2007-22502"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30415-0"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.15620\/cdc.5571"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.7249\/MG720.1"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nec.2016.05.009"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.4085\/1062-6050-51.3.05"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1249\/01.MSS.0000152734.47516.AA"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-019-0201-x"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2007.0348"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2015.4338"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12808"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0086-2"},{"key":"e_1_3_6_14_2","first-page":"97882P","article-title":"Quantification of traumatic meningeal injury using dynamic contrast enhanced (DCE) fluid-attenuated inversion recovery (FLAIR) imaging, in: Medical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging","author":"Castro M.A.","year":"2016","unstructured":"Castro M.A., , Williford J.P., , Cota M.R., , MacLaren J.M., , Dardzinski B.J., , Latour L.L., , Pham D.L., , and Butman J.A. (2016). Quantification of traumatic meningeal injury using dynamic contrast enhanced (DCE) fluid-attenuated inversion recovery (FLAIR) imaging, in: Medical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging. International Society for Optics and Photonics: Bellingham, WA, p. 97882P.","journal-title":"International Society for Optics and Photonics: Bellingham, WA, p"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0234881"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2019.6483"},{"issue":"156","key":"e_1_3_6_17_2","first-page":"107","article-title":"Where are we?","author":"Coles J.A.","year":"2017","unstructured":"Coles J.A., , Myburgh E., , Brewer J.M., , and McMenamin P.G. (2017). Where are we?. The anatomy of the murine cortical meninges revisited for intravital imaging,, immunology, and clearance of waste from the brain. Prog. Neurobiol. 156, 107\u2013148.","journal-title":"The anatomy of the murine cortical meninges revisited for intravital imaging,"},{"key":"e_1_3_6_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcaa143"},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.1682\/JRRD.2013.02.0049"},{"key":"e_1_3_6_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.193797"},{"key":"e_1_3_6_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-9-55"},{"key":"e_1_3_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2020.113409"},{"key":"e_1_3_6_23_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2019.6602"},{"key":"e_1_3_6_24_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2021.0025"},{"key":"e_1_3_6_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-018-0461-0"},{"key":"e_1_3_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2019.02.012"},{"key":"e_1_3_6_27_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-021-02195-y"},{"key":"e_1_3_6_28_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2021.0096"},{"key":"e_1_3_6_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.24705"},{"key":"e_1_3_6_30_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI67677"},{"key":"e_1_3_6_31_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2016.4870"},{"key":"e_1_3_6_32_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2018.5731"},{"key":"e_1_3_6_33_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0102229"},{"key":"e_1_3_6_34_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.174.1.2294578"},{"key":"e_1_3_6_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/jon.12726"},{"key":"e_1_3_6_36_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546513487982"},{"key":"e_1_3_6_37_2","first-page":"864","article-title":"Hockey Concussion Education Project, Part 1","volume":"120","author":"Helmer K.G.","year":"2014","unstructured":"Helmer K.G., , Pasternak O., , Fredman E., , Preciado R.I., , Koerte I.K., , Sasaki T., , Mayinger M., , Johnson A.M., , Holmes J.D., , and Forwell L.A. (2014). Hockey Concussion Education Project, Part 1. Susceptibility-weighted imaging study in male and female ice hockey players over a single season. J. Neurosurg. 120, 864\u2013872.","journal-title":"Susceptibility-weighted imaging study in male and female ice hockey players over a single season. J. Neurosurg"},{"key":"e_1_3_6_38_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.14132512"},{"key":"e_1_3_6_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2016.05.036"},{"key":"e_1_3_6_40_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.1997.14.839"},{"key":"e_1_3_6_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2005.12.106"},{"key":"e_1_3_6_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2019.01.017"},{"key":"e_1_3_6_43_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx350"},{"key":"e_1_3_6_44_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa140"},{"key":"e_1_3_6_45_2","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0164-17.2017"},{"key":"e_1_3_6_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micromeso.2017.05.030"},{"key":"e_1_3_6_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-25737-6"},{"key":"e_1_3_6_48_2","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.42109"},{"key":"e_1_3_6_49_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0197346"},{"key":"e_1_3_6_50_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa447"},{"key":"e_1_3_6_51_2","doi-asserted-by":"publisher","DOI":"10.1093\/ilar.49.1.17"},{"key":"e_1_3_6_52_2","doi-asserted-by":"publisher","DOI":"10.1002\/ame2.12167"},{"key":"e_1_3_6_53_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2020.7288"},{"key":"e_1_3_6_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2019.09.044"},{"key":"e_1_3_6_55_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902250310"},{"key":"e_1_3_6_56_2","doi-asserted-by":"publisher","DOI":"10.30802\/AALAS-CM-19-000022"},{"key":"e_1_3_6_57_2","doi-asserted-by":"publisher","DOI":"10.1002\/ca.23635"},{"key":"e_1_3_6_58_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-3816-2_17"},{"key":"e_1_3_6_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2011.09.018"},{"key":"e_1_3_6_60_2","first-page":"3206","article-title":"Characterization of signal enhancement following the intraperitoneal injection of Gadolinium based contrast agents","author":"Portnoy S.","year":"2008","unstructured":"Portnoy S., , Bishop J., , Dazai J., , Spring S., , and Henkelman R. (2008). Characterization of signal enhancement following the intraperitoneal injection of Gadolinium based contrast agents. Proc. Int. Soc. Mag. Reson. Med. 3206.","journal-title":"Proc. Int. Soc. Mag. Reson. Med"},{"key":"e_1_3_6_61_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24365"},{"key":"e_1_3_6_62_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1924.02650480007004"},{"key":"e_1_3_6_63_2","first-page":"111","article-title":"The \u201csubdural\u201d","volume":"32","author":"Haines D.E.","year":"1993","unstructured":"Haines D.E., , Harkey H.L., , and Al-Mefty O. (1993). The \u201csubdural\u201d. space: a new look at an outdated concept. Neurosurgery, 32, 111\u2013120.","journal-title":"space: a new look at an outdated concept. Neurosurgery"},{"key":"e_1_3_6_64_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2016.4479"},{"key":"e_1_3_6_65_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901640202"},{"key":"e_1_3_6_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2018.09.009"},{"key":"e_1_3_6_67_2","first-page":"907","article-title":"Radiological-pathological correlation of diffusion tensor and magnetization transfer imaging in closed head traumatic brain injury model Ann","volume":"79","author":"Tu T.-W.","year":"2016","unstructured":"Tu T.-W., , Williams R.A., , Lescher J.D., , Neekita J., , Turtzo C., , and Frank J.A. (2016). Radiological-pathological correlation of diffusion tensor and magnetization transfer imaging in closed head traumatic brain injury model Ann. Neurol. 79, 907\u2013920.","journal-title":"Neurol"}],"container-title":["Journal of Neurotrauma"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/neu.2021.0494","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/neu.2021.0494","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/neu.2021.0494","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:40:00Z","timestamp":1777675200000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/neu.2021.0494"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":66,"journal-issue":{"issue":"11-12","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1089\/neu.2021.0494"],"URL":"https:\/\/doi.org\/10.1089\/neu.2021.0494","relation":{},"ISSN":["0897-7151","1557-9042"],"issn-type":[{"value":"0897-7151","type":"print"},{"value":"1557-9042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6]]}}}