{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T03:17:05Z","timestamp":1787887025278,"version":"build-2784847793"},"reference-count":47,"publisher":"SAGE Publications","issue":"19-20","license":[{"start":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T00:00:00Z","timestamp":1664409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:p>\n                    Severe traumatic brain injury (TBI) results in cognitive dysfunction in part due to vascular perturbations. In contrast, the long-term vasculo-cognitive pathophysiology of mild TBI (mTBI) remains unknown. We evaluated mTBI effects on chronic cognitive and cerebrovascular function and assessed their interrelationships. Sprague-Dawley rats received midline fluid percussion injury (\n                    <jats:italic toggle=\"yes\">n\u2009=<\/jats:italic>\n                    \u200920) or sham (\n                    <jats:italic toggle=\"yes\">n\u2009=<\/jats:italic>\n                    \u200921). Cognitive function was assessed (3- and 6-month novel object recognition [NOR], novel object location [NOL], and temporal order object recognition [TOR]). Six-month cerebral blood flow (CBF) and cerebral blood volume (CBV) using contrast magnetic resonance imaging (MRI) and\n                    <jats:italic toggle=\"yes\">ex vivo<\/jats:italic>\n                    circle of Willis artery endothelial and smooth muscle-dependent function were measured. mTBI rats showed significantly impaired NOR, with similar trends (non-significant) in NOL\/TOR. Regional CBF and CBV were similar in sham and mTBI. NOR correlated with CBF in lateral hippocampus, medial hippocampus, and primary somatosensory barrel cortex, whereas it inversely correlated with arterial smooth muscle-dependent dilation. Six-month baseline endothelial and smooth muscle-dependent arterial function were similar among mTBI and sham, but post-angiotensin 2 stimulation, mTBI showed no change in smooth muscle-dependent dilation from baseline response, unlike the reduction in sham. mTBI led to chronic cognitive dysfunction and altered angiotensin 2-stimulated smooth muscle-dependent vasoreactivity. The findings of persistent pathophysiological consequences of mTBI in this animal model add to the broader understanding of chronic pathophysiological sequelae in human mild TBI.\n                  <\/jats:p>","DOI":"10.1089\/neu.2022.0015","type":"journal-article","created":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T03:23:40Z","timestamp":1653017020000},"page":"1429-1441","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Chronic Cognitive and Cerebrovascular Function after Mild Traumatic Brain Injury in Rats"],"prefix":"10.1177","volume":"39","author":[{"given":"Daniel R.","family":"Griffiths","sequence":"first","affiliation":[{"name":"Phoenix VA Health Care System, Phoenix, Arizona, USA."},{"name":"University of Arizona College of Medicine \u2013 Phoenix, Phoenix, Arizona, USA."},{"name":"Barrow Neurological Institute at Phoenix Children's Hospital, Phoenix, Arizona, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Matthew","family":"Law","sequence":"additional","affiliation":[{"name":"Phoenix VA Health Care System, Phoenix, Arizona, USA."},{"name":"University of Arizona College of Medicine \u2013 Phoenix, Phoenix, Arizona, USA."},{"name":"Barrow Neurological Institute at Phoenix Children's Hospital, Phoenix, Arizona, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conor","family":"Young","sequence":"additional","affiliation":[{"name":"University of Arizona College of Medicine \u2013 Phoenix, Phoenix, Arizona, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Fuentes","sequence":"additional","affiliation":[{"name":"Barrow Neurological Institute, Phoenix, Arizona, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth","family":"Truran","sequence":"additional","affiliation":[{"name":"Phoenix VA Health Care System, Phoenix, Arizona, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Karamanova","sequence":"additional","affiliation":[{"name":"Phoenix VA Health Care System, Phoenix, Arizona, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura C.","family":"Bell","sequence":"additional","affiliation":[{"name":"Barrow Neurological Institute, Phoenix, Arizona, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Turner","sequence":"additional","affiliation":[{"name":"Barrow Neurological Institute, Phoenix, Arizona, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Emerson","sequence":"additional","affiliation":[{"name":"Phoenix VA Health Care System, Phoenix, Arizona, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Mastroeni","sequence":"additional","affiliation":[{"name":"Arizona State University, Tempe, Arizona, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rayna J.","family":"Gonzales","sequence":"additional","affiliation":[{"name":"University of Arizona College of Medicine \u2013 Phoenix, Phoenix, Arizona, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter D.","family":"Reaven","sequence":"additional","affiliation":[{"name":"Phoenix VA Health Care System, Phoenix, Arizona, USA."},{"name":"University of Arizona College of Medicine \u2013 Phoenix, Phoenix, Arizona, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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