{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:41:52Z","timestamp":1777927312033,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"19-20","license":[{"start":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T00:00:00Z","timestamp":1664409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:p>\n                    Aeromedical evacuation-relevant hypobaria after traumatic brain injury (TBI) leads to increased neurological injury and death in rats relative to those maintained under normobaria. Applicability of rodent brain injury research to humans may be limited, however, by differences in neuroanatomy. Therefore, we developed a model in which ferrets are exposed to polytrauma consisting of controlled cortical impact TBI and hemorrhagic shock subjected 24\u2009h later to 6\u2009h of hypobaria or normobaria. Our objective was to determine whether the deleterious effects of hypobaria observed in rats, with lissencephalic brains, are also present in a species with a human-like gyrencephalic brain. While no deaths were observed, magnetic resonance spectroscopy (MRS) results obtained two days post-injury indicated reduced cortical creatine,\n                    <jats:italic toggle=\"yes\">N<\/jats:italic>\n                    -acetylaspartate, gamma-aminobutyric acid, myo-inositol, and glutamate that were not affected by hypobaria. T\n                    <jats:sub>2<\/jats:sub>\n                    -weighted magnetic resonance imaging quantification revealed increased hyperintensity volume representing cortical edema at the site of impact after polytrauma. Hypobaria did not exacerbate this focal edema but did lead to overall reductions in total cortical volume. Both normobaric and hypobaric ferrets exhibited impaired spatial memory six days post-injury on the Object Location Test, but no differences were noted between groups. Finally, cortical lesion volume was not exacerbated by hypobaria exposure on day 7 post-injury. Results suggest that air travel 24\u2009h after polytrauma is associated with structural changes in the ferret brain. Future studies should investigate secondary injury from hypobaria after polytrauma in greater detail including alternative outcome measures, time points, and exposure to multiple flights.\n                  <\/jats:p>","DOI":"10.1089\/neu.2022.0102","type":"journal-article","created":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T09:52:06Z","timestamp":1651139526000},"page":"1442-1452","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Combined Traumatic Brain Injury and Hemorrhagic Shock in Ferrets Leads to Structural, Neurochemical, and Functional Impairments"],"prefix":"10.1177","volume":"39","author":[{"given":"Molly J.","family":"Goodfellow","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and the Center for Shock, Trauma and Anesthesiology (STAR) Research, University of Maryland School of Medicine, Baltimore, Maryland, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana A.","family":"Medina","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and the Center for Shock, Trauma and Anesthesiology (STAR) Research, University of Maryland School of Medicine, Baltimore, Maryland, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie L.","family":"Proctor","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and the Center for Shock, Trauma and Anesthesiology (STAR) Research, University of Maryland School of Medicine, Baltimore, Maryland, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, University of Maryland School of Medicine, Baltimore, Maryland, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rao P.","family":"Gullapalli","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, University of Maryland School of Medicine, Baltimore, Maryland, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parisa","family":"Rangghran","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and the Center for Shock, Trauma and Anesthesiology (STAR) Research, University of Maryland School of Medicine, Baltimore, Maryland, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catriona","family":"Miller","sequence":"additional","affiliation":[{"name":"US Air Force School of Aerospace Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Vesselinov","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and the Center for Shock, Trauma and Anesthesiology (STAR) Research, University of Maryland School of Medicine, Baltimore, Maryland, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"Fiskum","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and the Center for Shock, Trauma and Anesthesiology (STAR) Research, University of Maryland School of Medicine, Baltimore, Maryland, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,9,29]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2009.07.040"},{"key":"e_1_3_5_3_2","first-page":"e138","article-title":"Influence of time to transport to a higher level facility on the clinical outcomes of US combat casualties with TBI: a multicenter 7-year study","volume":"185","author":"Maddry J.K.","year":"2020","unstructured":"Maddry J.K., , Arana A.A., , Perez C.A., , Medellin K.L., , Paciocco J.A., , Mora A.G., , Holder W.G., , Davis W.T., , Herson P.S., , and Bebarta V.S. 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