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The Lund concept is a treatment algorithm for severe TBI aiming at controlling intracranial pressure (ICP) by reducing cerebral perfusion pressure (CPP). The aim of the present study was to retrospectively assess mortality and morbidity in a population of pediatric TBI treated according to the Lund concept. All cases of severe pediatric TBI (age &lt;18 years) in the southern region of Sweden during 19 years were identified. Patients were treated according to the Lund concept. Mortality, eGOS, ICP, CPP, time in the neurosurgical intensive care unit (NICU), drugs delivered and surgical procedures were recorded. Data were analyzed both by dichotomized outcomes and by ordinal statistics. A total of 135 cases of severe TBI &lt;18 years of age were recorded (incidence 2.0\/100000) and 86 patients were admitted to the tertiary NICU. Mortality including all cases was 43% (mortality rate 0.7\/100,000) and in NICU 10%. Outcome was good in 60%, moderate in 25%, unfavorable in 15%, with none in a vegetative status. In both dichotomized and ordinal analyses, CPP &lt;40\u2009mm Hg and ICP &gt;15 were associated with poor outcome, supporting current guidelines. However, high CPP also was associated with increased mortality and morbidity, supporting that elevated CPP might increase cerebral edema. In this study, the Lund concept resulted in low mortality and a favorable outcome in a majority of severe pediatric TBI patients; however, randomized controlled trials are warranted to verify this.<\/jats:p>","DOI":"10.1089\/neu.2022.0116","type":"journal-article","created":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T06:23:27Z","timestamp":1670307807000},"page":"720-729","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Low Morbidity and Mortality in Children with Severe Traumatic Brain Injury Treated According to the Lund Concept: A Population-Based Study"],"prefix":"10.1177","volume":"40","author":[{"given":"Linus","family":"R\u00e9en","sequence":"first","affiliation":[{"name":"Section of Neurosurgery, Department of Clinical Sciences, Lund University, Lund, Sweden."},{"name":"Department of Neurosurgery, Sk\u00e5ne University Hospital, Lund, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Cederberg","sequence":"additional","affiliation":[{"name":"Section of Neurosurgery, Department of Clinical Sciences, Lund University, Lund, Sweden."},{"name":"Department of Neurosurgery, Sk\u00e5ne University Hospital, Lund, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Radman","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Sk\u00e5ne University Hospital, Lund, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"Marklund","sequence":"additional","affiliation":[{"name":"Section of Neurosurgery, Department of Clinical Sciences, Lund University, Lund, Sweden."},{"name":"Department of Neurosurgery, Sk\u00e5ne University Hospital, Lund, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Visse","sequence":"additional","affiliation":[{"name":"Section of Neurosurgery, Department of Clinical Sciences, Lund University, Lund, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Siesj\u00f6","sequence":"additional","affiliation":[{"name":"Section of Neurosurgery, Department of Clinical Sciences, Lund University, Lund, Sweden."},{"name":"Department of Neurosurgery, Sk\u00e5ne University Hospital, Lund, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,3,28]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5151.134152"},{"issue":"4","key":"e_1_3_6_3_2","first-page":"25","article-title":"Prognostic factors of severe traumatic brain injury outcome in children aged 2-16 years at a major neurosurgical referral centre","volume":"16","author":"Kan CH","year":"2009","unstructured":"Kan CH, , Saffari M, , Khoo TH. 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