{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T19:28:45Z","timestamp":1788982125552,"version":"build-2803163510"},"reference-count":57,"publisher":"SAGE Publications","issue":"5-6","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:p>\n                    Following traumatic brain injury (TBI), cerebral metabolic dysfunction, characterized by an elevated cerebral microdialysis (CMD) lactate\/pyruvate (LP) ratio, is associated with poor outcome. However, the exact pathophysiological mechanisms underlying this association are not entirely established. In this pre-planned analysis of the BIOmarkers of AXonal injury after Traumatic Brain Injury (BIO-AX-TBI) prospective study, we investigated any associations of LP ratio with brain structure volume change rates at 1 year. Fourteen subjects underwent acute-phase (0\u201396\u2009h post-TBI) CMD monitoring and had longitudinal magnetic resonance imaging (MRI) quantification of brain volume loss between the subacute phase (14 days to 6 weeks) and 1 year after TBI, recalculated as an annual rate. On average, CMD showed an elevated (&gt;25) LP ratio (31 [interquartile range (IQR) 24\u201334]), indicating acute cerebral metabolic dysfunction. Annualized whole brain and total gray matter (GM) volume change rates were abnormally reduced (\u22123.2% [\u22129.3 to \u22122.2] and \u22121.9% [\u22124.4 to 1.7], respectively). Reduced annualized total GM volume correlated significantly with elevated CMD LP ratio (Spearman's \u03c1\u2009=\u2009\u22120.68,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    -value\u2009=\u20090.01) and low CMD glucose (\u03c1\u2009=\u20090.66,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    -value\u2009=\u20090.01). After adjusting for age, admission Glasgow Coma Scale (GCS) score and CT Marshall score, CMD LP ratio remained strongly associated with 1-year total GM volume change rate (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001; multi-variable analysis). No relationship was found between WM volume changes and CMD metabolites. We demonstrate a strong association between acute post-traumatic cerebral metabolic dysfunction and 1-year gray matter atrophy, reinforcing the role of CMD LP ratio as an early biomarker of poor long-term recovery after TBI.\n                  <\/jats:p>","DOI":"10.1089\/neu.2022.0161","type":"journal-article","created":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T02:31:47Z","timestamp":1664850707000},"page":"472-481","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Cerebral Metabolic Dysfunction at the Acute Phase of Traumatic Brain Injury Correlates with Long-Term Tissue Loss"],"prefix":"10.1177","volume":"40","author":[{"given":"Adriano","family":"Bernini","sequence":"first","affiliation":[{"name":"Neuroscience Critical Care Research Group, Department of Intensive Care Medicine, Centre Hospitalier Universitaire Vaudois (CHUV) - Lausanne University Hospital and Faculty of Biology and Medicine, Lausanne, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Magnoni","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care, Santa Chiara Hospital, Trento, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John-Paul","family":"Miroz","sequence":"additional","affiliation":[{"name":"Neuroscience Critical Care Research Group, Department of Intensive Care Medicine, Centre Hospitalier Universitaire Vaudois (CHUV) - Lausanne University Hospital and Faculty of Biology and Medicine, Lausanne, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Corredor-Jerez","sequence":"additional","affiliation":[{"name":"Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland."},{"name":"Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland."},{"name":"LTS5, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), Lausanne, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Bertolini","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Epidemiology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, M\u00f6lndal, Sweden."},{"name":"Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, M\u00f6lndal, Sweden."},{"name":"Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom."},{"name":"UK Dementia Research Institute at UCL, University College London, London, United Kingdom."},{"name":"Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Graham","sequence":"additional","affiliation":[{"name":"Department of Brain Sciences, Imperial College London, London, United Kingdom."},{"name":"UK DRI Centre for Care Research and Technology, Imperial College London, London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Sharp","sequence":"additional","affiliation":[{"name":"Department of Brain Sciences, Imperial College London, London, United Kingdom."},{"name":"UK DRI Centre for Care Research and Technology, Imperial College London, London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Oddo","sequence":"additional","affiliation":[{"name":"Neuroscience Critical Care Research Group, Department of Intensive Care Medicine, Centre Hospitalier Universitaire Vaudois (CHUV) - 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