{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:52:26Z","timestamp":1782604346491,"version":"3.54.5"},"reference-count":60,"publisher":"SAGE Publications","issue":"5-6","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:p>\n                    Despite enormous research interest in diffusion tensor imaging and diffusion kurtosis imaging (DTI; DKI) following mild traumatic brain injury (MTBI), it remains unknown how diffusion in white matter evolves post-injury and relates to acute MTBI characteristics. This prospective cohort study aimed to characterize diffusion changes in white matter the first year after MTBI. Patients with MTBI (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u2009193) and matched controls (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200983) underwent 3T magnetic resonance imaging (MRI) within 72\u2009h and 3- and 12-months post-injury. Diffusion data were analyzed in three steps: 1) voxel-wise comparisons between the MTBI and control group were performed with tract-based spatial statistics at each time-point; 2) clusters of significant voxels identified in step 1 above were evaluated longitudinally with mixed-effect models; 3) the MTBI group was divided into: (A) complicated (with macrostructural findings on MRI) and uncomplicated MTBI; (B) long (1-24\u2009h) and short (&lt; 1\u2009h) post-traumatic amnesia (PTA); and (C) other and no other concurrent injuries to investigate if findings in step 1 were driven mainly by aberrant diffusion in patients with a more severe injury. At 72\u2009h, voxel-wise comparisons revealed significantly lower fractional anisotropy (FA) in one tract and significantly lower mean kurtosis (Kmean) in 11 tracts in the MTBI compared with control group. At 3 months, the MTBI group had significantly higher mean diffusivity in eight tracts compared with controls. At 12 months, FA was significantly lower in four tracts and Kmean in 10 tracts in patients with MTBI compared with controls. There was considerable overlap in affected tracts across time, including the corpus callosum, corona radiata, internal and external capsule, and cerebellar peduncles. Longitudinal analyses revealed that the diffusion metrics remained relatively stable throughout the first year after MTBI. The significant group*time interactions identified were driven by changes in the control rather than the MTBI group. Further, differences identified in step 1 did not result from greater diffusion abnormalities in patients with complicated MTBI, long PTA, or other concurrent injuries, as standardized mean differences in diffusion metrics between the groups were small (0.07\u2009\u00b1\u20090.11) and non-significant. However, follow-up voxel-wise analyses revealed that other concurrent injuries had effects on diffusion metrics, but predominantly in other metrics and at other time-points than the effects observed in the MTBI versus control group analysis. In conclusion, patients with MTBI differed from controls in white matter integrity already 72\u2009h after injury. Diffusion metrics remained relatively stable throughout the first year after MTBI and were not driven by deviating diffusion in patients with a more severe MTBI.\n                  <\/jats:p>","DOI":"10.1089\/neu.2022.0206","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T05:45:20Z","timestamp":1666935920000},"page":"457-471","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Diffusion Tensor and Kurtosis Imaging Findings the First Year following Mild Traumatic Brain Injury"],"prefix":"10.1177","volume":"40","author":[{"given":"Jonas","family":"Stenberg","sequence":"first","affiliation":[{"name":"Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology (NTNU), Trondheim, Norway."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toril","family":"Skandsen","sequence":"additional","affiliation":[{"name":"Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology (NTNU), Trondheim, Norway."},{"name":"Department of Physical Medicine and Rehabilitation, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kent","family":"G\u00f8ran Moen","sequence":"additional","affiliation":[{"name":"Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology (NTNU), Trondheim, Norway."},{"name":"Department of Radiology, Vestre Viken Hospital Trust, Drammen Hospital, Drammen, Norway."},{"name":"Department of Radiology, Nord-Tr\u00f8ndelag Hospital Trust, Levanger Hospital, Levanger, Norway."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Vik","sequence":"additional","affiliation":[{"name":"Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology (NTNU), Trondheim, 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