{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:42:18Z","timestamp":1777927338301,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"23-24","license":[{"start":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T00:00:00Z","timestamp":1669766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:p>\n                    Spinal cord injury (SCI) results in devastating cardiovascular dysfunction. Noxious stimuli from the rectum during bowel routine often trigger life-threatening blood pressure surges, termed autonomic dysreflexia (AD). Rectal application of anesthetic lidocaine jelly has been recommended during bowel care to reduce AD severity by mitigating sensory input. However, clinical studies have reported contradicting evidence. We performed a pre-clinical study on the efficacy of rectal lidocaine in a standardized rodent T3 transection model. We found that 2% and 10% lidocaine significantly reduced AD severity by 32% and 50%, respectively, compared with control (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.0001). Our pre-clinical experiments support the current recommendation of rectal lidocaine application during bowel care.\n                  <\/jats:p>","DOI":"10.1089\/neu.2022.0274","type":"journal-article","created":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T10:22:10Z","timestamp":1659694930000},"page":"1764-1768","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Rectal Application of Lidocaine Reduces the Severity of Autonomic Dysreflexia following Experimental Spinal Cord Injury"],"prefix":"10.1177","volume":"39","author":[{"given":"Rahul","family":"Sachdeva","sequence":"first","affiliation":[{"name":"International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, Canada."},{"name":"Department of Medicine, University of British Columbia, Vancouver, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamila","family":"Kalimullina","sequence":"additional","affiliation":[{"name":"International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, Canada."},{"name":"Department of Medicine, University of British Columbia, Vancouver, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiran","family":"Pawar","sequence":"additional","affiliation":[{"name":"International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, Canada."},{"name":"Department of Medicine, University of British Columbia, Vancouver, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrei","family":"Krassioukov","sequence":"additional","affiliation":[{"name":"International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, Canada."},{"name":"Department of Medicine, University of British Columbia, Vancouver, Canada."},{"name":"GF Strong Rehabilitation Center, Vancouver Coastal Health, Vancouver, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,11,30]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.sc.3101729"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.62.5.473"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/10790268.2008.11753978"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1179\/2045772313Y.0000000098"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2014.45"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.4629\/2\/sci2702-225"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2010.1382"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-021-01034-5"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.7547\/87507315-86-10-487"},{"key":"e_1_3_5_11_2","author":"Nau C","unstructured":"Nau C, , Wang GK. Interactions of local anesthetics with voltage-gated Na+ channels. J Membrane Biol 2004;201:1\u20138; https:\/\/doi.org\/10.1007\/s00232-004-0702-y.","journal-title":"J Membrane Biol"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2008.86"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s003840100347"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41393-019-0381-2"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-005-0095-8"},{"key":"e_1_3_5_16_2","author":"Osborn JW","unstructured":"Osborn JW, , Taylor RF, , Schramm LP. Chronic cervical spinal cord injury and autonomic hyperreflexia in rats. Am J Physiol 1990;258(1):R169\u2013174; doi.org\/10.1152\/ajpregu.1990.258.1.R169.","journal-title":"Am J Physiol"}],"container-title":["Journal of Neurotrauma"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/neu.2022.0274","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/neu.2022.0274","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/neu.2022.0274","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:41:22Z","timestamp":1777675282000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/neu.2022.0274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,30]]},"references-count":15,"journal-issue":{"issue":"23-24","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1089\/neu.2022.0274"],"URL":"https:\/\/doi.org\/10.1089\/neu.2022.0274","relation":{},"ISSN":["0897-7151","1557-9042"],"issn-type":[{"value":"0897-7151","type":"print"},{"value":"1557-9042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,30]]}}}