{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T07:09:26Z","timestamp":1783753766090,"version":"3.55.0"},"reference-count":18,"publisher":"SAGE Publications","issue":"9-10","license":[{"start":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T00:00:00Z","timestamp":1682640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:p>\n                    The aim of this prospective phase IIa, open-label exploratory, pre\u2013post study was to determine the efficacy of fesoterodine (i.e., 12-week treatment period) to ameliorate autonomic dysreflexia (AD) in individuals with chronic SCI (&gt; 1-year post-injury) at or above the sixth thoracic spinal segment, with confirmed history of AD and neurogenic detrusor overactivity (NDO). Twelve participants (four females, eight males; median age 42 years) completed this study and underwent urodynamics, 24-h ambulatory blood pressure monitoring (ABPM), and urinary incontinence-related quality of life (QoL) measures at baseline and on-treatment. The Montreal Cognitive Assessment (MoCA) and Neurogenic Bowel Dysfunction (NBD) score were used to monitor cognitive and bowel function, respectively. Compared with baseline, fesoterodine improved lower urinary tract (LUT) function, that is, increased cystometric capacity (205 vs. 475\u2009mL,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.002) and decreased maximum detrusor pressure (44 vs. 12\u2009cm H\n                    <jats:sub>2<\/jats:sub>\n                    O,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.009). NDO was eliminated in seven (58%) participants. Severity of AD events during urodynamics (40 vs. 27\u2009mm Hg,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.08) and 24-h ABPM (59 vs. 36\u2009mm Hg,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.05) were both reduced, yielding a large effect size (\n                    <jats:italic toggle=\"yes\">r<\/jats:italic>\n                    \u2009=\u2009-0.58). AD Frequency (14 vs. 3,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.004) during 24-h ABPM was significantly reduced. Urinary incontinence-related QoL improved (68 vs. 82,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.02), however, cognitive (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.2) and bowel function (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.4) did not change significantly. In conclusion, fesoterodine reduces the magnitude and frequency of AD, while improving LUT function and urinary incontinence-related QoL in individuals with chronic SCI without negatively affecting cognitive or bowel function.\n                  <\/jats:p>","DOI":"10.1089\/neu.2022.0333","type":"journal-article","created":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T09:46:49Z","timestamp":1664531209000},"page":"1020-1025","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Fesoterodine Ameliorates Autonomic Dysreflexia While Improving Lower Urinary Tract Function and Urinary Incontinence-Related Quality of Life in Individuals With Spinal Cord Injury: A Prospective Phase IIa Study"],"prefix":"10.1177","volume":"40","author":[{"given":"Matthias","family":"Walter","sequence":"first","affiliation":[{"name":"International Collaboration on Repair Discoveries (ICORD), Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada."},{"name":"Department of Urology, University Hospital Basel, University of Basel, Basel, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea L.","family":"Ramirez","sequence":"additional","affiliation":[{"name":"International Collaboration on Repair Discoveries (ICORD), Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda H. X.","family":"Lee","sequence":"additional","affiliation":[{"name":"International Collaboration on Repair Discoveries (ICORD), Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"Nightingale","sequence":"additional","affiliation":[{"name":"International Collaboration on Repair Discoveries (ICORD), Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada."},{"name":"School of Sport, Exercise, and Rehabilitation Sciences, University of Birmingham, Birmingham, United Kingdom."},{"name":"Center for Trauma Sciences Research, University of Birmingham, Edgbaston, Birmingham, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Rapoport","sequence":"additional","affiliation":[{"name":"Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Kavanagh","sequence":"additional","affiliation":[{"name":"Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei V.","family":"Krassioukov","sequence":"additional","affiliation":[{"name":"International Collaboration on Repair Discoveries (ICORD), Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada."},{"name":"Division of Physical Medicine and Rehabilitation, University of British Columbia, Vancouver, British Columbia, Canada."},{"name":"G.F. Strong Rehabilitation Centre, Vancouver, British Columbia, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,4,28]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-018-1040-8"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1179\/2045772313Y.0000000098"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2020.7115"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-024084"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1179\/204577211X13207446293695"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/nau.10066"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01816"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpu122"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0090-4295(99)80384-7"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.sc.3101887"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53221.x"},{"key":"e_1_3_5_13_2","unstructured":"Rosenthal R. Parametric measures of effect size. In: The Handbook of Research Synthesis. Russell Sage Foundation: New York NY; 1994; pp. 231\u2013244."},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-019-02981-7"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2013.08.027"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afv077"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afw252"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000006244"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182a1aa68"}],"container-title":["Journal of Neurotrauma"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/neu.2022.0333","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/neu.2022.0333","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/neu.2022.0333","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:41:37Z","timestamp":1777675297000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/neu.2022.0333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,28]]},"references-count":18,"journal-issue":{"issue":"9-10","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1089\/neu.2022.0333"],"URL":"https:\/\/doi.org\/10.1089\/neu.2022.0333","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.07.14.22277625","asserted-by":"object"}]},"ISSN":["0897-7151","1557-9042"],"issn-type":[{"value":"0897-7151","type":"print"},{"value":"1557-9042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,28]]}}}