{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T04:06:14Z","timestamp":1779336374953,"version":"3.51.4"},"reference-count":60,"publisher":"SAGE Publications","issue":"23-24","license":[{"start":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T00:00:00Z","timestamp":1701302400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:p>\n                    Following spinal cord injury (SCI), fibrotic scar inhibits axon regeneration and impairs neurological function recovery. It has been reported that T cell\u2013derived interferon (IFN)-\u03b3 plays a pivotal role in promoting fibrotic scarring in neurodegenerative disease. However, the role of IFN-\u03b3 in fibrotic scar formation after SCI has not been declared. In this study, a spinal cord crush injury mouse was established. Western blot and immunofluorescence showed that IFN-\u03b3 was surrounded by fibroblasts at 3, 7, 14, and 28 days post-injury. Moreover, IFN-\u03b3 is mainly secreted by T cells after SCI. Further,\n                    <jats:italic toggle=\"yes\">in situ<\/jats:italic>\n                    injection of IFN-\u03b3 into the normal spinal cord resulted in fibrotic scar formation and inflammation response at 7 days post-injection. After SCI, the intraperitoneal injection of fingolimod (FTY720), a sphingosine-1-phosphate receptor 1 (S1PR1) modulator and W146, an S1PR1 antagonist, significantly reduced T cell infiltration, attenuating fibrotic scarring via inhibiting IFN-\u03b3\/IFN-\u03b3R pathway, while\n                    <jats:italic toggle=\"yes\">in situ<\/jats:italic>\n                    injection of IFN-\u03b3 diminished the effect of FTY720 on reducing fibrotic scarring. FTY720 treatment inhibited inflammation, decreased lesion size, and promoted neuroprotection and neurological recovery after SCI. These findings demonstrate that the inhibition of T cell-derived IFN-\u03b3 by FTY720 suppressed fibrotic scarring and contributed to neurological recovery after SCI.\n                  <\/jats:p>","DOI":"10.1089\/neu.2022.0387","type":"journal-article","created":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T00:40:20Z","timestamp":1678149620000},"page":"2580-2595","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Fingolimod (FTY720) Hinders Interferon-\u03b3-Mediated Fibrotic Scar Formation and Facilitates Neurological Recovery After Spinal Cord Injury"],"prefix":"10.1177","volume":"40","author":[{"given":"Yiteng","family":"Li","sequence":"first","affiliation":[{"name":"Department of Orthopedics, the Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China."},{"name":"Institute of Orthopedics, Research Center for Translational Medicine, the Second Affiliated Hospital of Anhui 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