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Christopher Reeve was an actor who became quadriplegic and started the Christopher &amp; Dana Reeve Foundation (CDRF), and Robert Grossman was a neurosurgeon experienced in neurotrauma and a university professor in Houston. NACTN has member investigators at university and military centers in North America and has contributed greatly to the improvement of care, primarily acute care, of patients sustaining traumatic SCI. Its accomplishments are a clinical registry database of &gt;1000 acute SCI patients documenting the care pathways, including complications. NACTN has assessed the effectiveness of treatment, including pharmacotherapy and the role and timing of surgery, and has also identified barriers to early surgery. The principal focus has been on improving neurological recovery. NACTN has trained many SCI practitioners and has collaborated with other SCI networks and organizations internationally to promote the care of SCI patients.<\/jats:p>","DOI":"10.1089\/neu.2022.0404","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T05:46:08Z","timestamp":1670996768000},"page":"1823-1833","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["History and Accomplishments of the North American Clinical Trials Network for Spinal Cord Injury, 2004\u20132022"],"prefix":"10.1177","volume":"40","author":[{"given":"Charles H.","family":"Tator","sequence":"first","affiliation":[{"name":"Division of Neurosurgery and Spine Program, Department of Surgery, University of Toronto, Toronto, Ontario, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James D.","family":"Guest","sequence":"additional","affiliation":[{"name":"Neurological Surgery and The Miami Project to Cure Paralysis, University of Miami, Miami, Florida, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris J.","family":"Neal","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Walter Reed National Military Medical Center, Bethesda Maryland, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan P.","family":"Howley","sequence":"additional","affiliation":[{"name":"Christopher &amp; Dana Reeve Foundation, Short Hills, New Jersey, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth G.","family":"Toups","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Houston Methodist Hospital, Houston Texas, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James S.","family":"Harrop","sequence":"additional","affiliation":[{"name":"Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bizhan","family":"Aarabi","sequence":"additional","affiliation":[{"name":"University of Maryland School of Medicine, Baltimore, Maryland, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher I.","family":"Shaffrey","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Duke University, Durham, North Carolina, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael G.","family":"Fehlings","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery and Spine Program, Department of Surgery, University of Toronto, Toronto, Ontario, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,8,23]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.3171\/2012.4.AOSPINE1294"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41393-019-0276-2"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007642"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1302\/2046-3758.35.2000265"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-021-05974-3"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1984.03340250025015"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199005173222001"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03540440031029"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200112151-00015"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200112151-00014"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-022-02395-0"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2021.0368"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.sc.3101669"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.sc.3102008"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.sc.3102010"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-191403000-00002"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1911.04260090100008"},{"key":"e_1_3_4_19_2","first-page":"10","article-title":"Spinal Cord Compression: Mechanisms of Paralysis and Treatment","author":"Tarlov IM.","year":"1957","unstructured":"Tarlov IM. 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