{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T12:28:33Z","timestamp":1793190513059,"version":"4.5.0"},"reference-count":43,"publisher":"SAGE Publications","issue":"1-2","license":[{"start":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T00:00:00Z","timestamp":1703808000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>\n                    The purpose of this study was to extend previous research by examining the relationship between lifetime blast exposure and neurobehavioral functioning after mild TBI (MTBI) by (a) using a comprehensive measure of lifetime blast exposure, and (b) controlling for the influence of post-traumatic stress disorder (PTSD). Participants were 103 United States service members and veterans (SMVs) with a medically documented diagnosis of MTBI, recruited from three military treatment facilities (74.8%) and community-based recruitment initiatives (25.2%, e.g., social media, flyers). Participants completed a battery of neurobehavioral measures 12 or more months post-injury (Neurobehavioral Symptom Inventory, PTSD-Checklist PCLC, TBI-Quality of Life), including the Blast Exposure Threshold Survey (BETS). The sample was classified into two lifetime blast exposure (LBE) groups: High (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200957) and Low (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200946) LBE. In addition, the sample was classified into four LBE\/PTSD subgroups: High PTSD\/High LBE (n\u2009=\u200938); High PTSD\/Low LBE (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200919); Low PTSD\/High LBE (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200919); and Low PTSD\/Low LBE (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200927). The High LBE group had consistently worse scores on all neurobehavioral measures compared with the Low LBE group. When controlling for the influence of PTSD (using ANCOVA), however, only a handful of group differences remained. When comparing measures across the four LBE\/PTSD subgroups, in the absence of clinically meaningful PTSD symptoms (i.e., Low PTSD), participants with High LBE had worse scores on the majority of neurobehavioral measures (e.g., post-concussion symptoms, sleep, fatigue). When examining the total number of clinically elevated measures, the High LBE subgroup consistently had a greater number of clinically elevated scores compared with the Low LBE subgroup for the majority of comparisons (i.e., four to 15 or more elevated symptoms). In contrast, in the presence of clinically meaningful PTSD symptoms (i.e., High PTSD), there were no differences between High versus Low LBE subgroups for all measures. When examining the total number of clinically elevated measures, however, there were meaningful differences between High versus Low LBE subgroups for those comparisons that included a high number of clinically elevated scores (i.e., six to 10 or more), but not for a low number of clinically elevated scores (i.e., one to five or more). High LBE, as quantified using a more comprehensive measure than utilized in past research (i.e., BETS), was associated with worse overall neurobehavioral functioning after MTBI. This study extends existing literature showing that lifetime blast exposure, that is largely subconcussive, may negatively impact warfighter brain health and readiness beyond diagnosable brain injury.\n                  <\/jats:p>","DOI":"10.1089\/neu.2023.0133","type":"journal-article","created":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T14:33:21Z","timestamp":1693492401000},"page":"186-198","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":25,"title":["High Lifetime Blast Exposure Using the Blast Exposure Threshold Survey Is Associated With Worse Warfighter Brain Health Following Mild Traumatic Brain Injury"],"prefix":"10.1177","volume":"41","author":[{"given":"Rael T.","family":"Lange","sequence":"first","affiliation":[{"name":"Traumatic Brain Injury Center of Excellence, Silver Spring, Maryland, USA."},{"name":"Walter Reed National Military Medical Center, Bethesda, Maryland, USA."},{"name":"National Intrepid Center of Excellence, Bethesda, Maryland, USA."},{"name":"Contractor, General Dynamics Information Technology, Silver Spring, Maryland, USA."},{"name":"University of British Columbia, Vancouver, British Columbia, Canada."},{"name":"Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis M.","family":"French","sequence":"additional","affiliation":[{"name":"Traumatic Brain Injury Center of Excellence, Silver Spring, Maryland, USA."},{"name":"Walter Reed National Military Medical Center, Bethesda, Maryland, USA."},{"name":"National Intrepid Center of Excellence, Bethesda, Maryland, USA."},{"name":"Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara M.","family":"Lippa","sequence":"additional","affiliation":[{"name":"Walter Reed National Military Medical Center, Bethesda, Maryland, USA."},{"name":"National Intrepid Center of Excellence, Bethesda, Maryland, USA."},{"name":"Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Gillow","sequence":"additional","affiliation":[{"name":"Traumatic Brain Injury Center of Excellence, Silver Spring, Maryland, USA."},{"name":"Walter Reed National Military Medical Center, Bethesda, Maryland, USA."},{"name":"National Intrepid Center of Excellence, Bethesda, Maryland, USA."},{"name":"Contractor, CICONIX, Annapolis, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corie E.","family":"Tippett","sequence":"additional","affiliation":[{"name":"Traumatic Brain Injury Center of Excellence, Silver Spring, Maryland, USA."},{"name":"Walter Reed National Military Medical Center, Bethesda, Maryland, USA."},{"name":"National Intrepid Center of Excellence, Bethesda, Maryland, USA."},{"name":"Contractor, CICONIX, Annapolis, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Barnhart","sequence":"additional","affiliation":[{"name":"Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA."},{"name":"Contractor, Henry Jackson Foundation, Bethesda, Maryland, USA."},{"name":"Center for Neuroscience and Regenerative Medicine, Bethesda, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan E.","family":"Glazer","sequence":"additional","affiliation":[{"name":"Walter Reed National Military Medical Center, Bethesda, Maryland, USA."},{"name":"National Intrepid Center of Excellence, Bethesda, Maryland, USA."},{"name":"Contractor, Henry Jackson Foundation, Bethesda, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason M.","family":"Bailie","sequence":"additional","affiliation":[{"name":"Traumatic Brain Injury Center of Excellence, Silver Spring, Maryland, 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