{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:10:19Z","timestamp":1787008219162,"version":"build-2736575974"},"reference-count":55,"publisher":"SAGE Publications","issue":"7-8","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:p>\n                    Spinal cord injury (SCI) is a debilitating neurological condition that often leads to central neuropathic pain (CNP). As the fundamental mechanism of CNP is not fully established, its management is one of the most challenging problems among people with SCI. To shed more light on CNP mechanisms, the aim of this cross-sectional study was to compare the brain structure between individuals with SCI and CNP and those without CNP by examining the gray matter (GM) volume and the white matter (WM) integrity. Fifty-two individuals with SCI\u201428 with CNP and 24 without CNP\u2014underwent a magnetic resonance imaging (MRI) session, including a T1-weighted scan for voxel-based morphometry, and a diffusion-weighted imaging (DWI) scan for WM integrity analysis, as measured by fractional anisotropy (FA) and mean diffusivity (MD). We found significantly higher GM volume in individuals with CNP compared with pain-free individuals in the right superior (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.0014) and middle temporal gyri (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.0001). Moreover, individuals with CNP exhibited higher WM integrity in the splenium of the corpus callosum (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.0001) and in the posterior cingulum (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.0001), compared with pain-free individuals. The results suggest that the existence of CNP following SCI is associated with GM and WM structural abnormalities in regions involved in pain intensification and spread, and which may reflect maladaptive neural plasticity in CNP.\n                  <\/jats:p>","DOI":"10.1089\/neu.2023.0146","type":"journal-article","created":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T06:42:31Z","timestamp":1699425751000},"page":"836-843","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Higher Regional Gray Matter Volume and White Matter Integrity in Individuals With Central Neuropathic Pain After Spinal Cord Injury"],"prefix":"10.1177","volume":"41","author":[{"given":"Abigail","family":"Livny","sequence":"first","affiliation":[{"name":"Division of Diagnostic Imaging, Sheba Medical Center, Tel HaShomer, Israel."},{"name":"Faculty of Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel."},{"name":"Sagol Neuroscience School, Tel Aviv University, Tel Aviv, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yael","family":"Golan","sequence":"additional","affiliation":[{"name":"Division of Diagnostic Imaging, Sheba Medical Center, Tel HaShomer, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nofar","family":"Itzhaki","sequence":"additional","affiliation":[{"name":"Division of Diagnostic Imaging, Sheba Medical Center, Tel HaShomer, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dafna","family":"Grossberg","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel."},{"name":"Rehabilitation Ambulatory Department, Sheba Medical Center, Tel HaShomer, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galia","family":"Tsarfaty","sequence":"additional","affiliation":[{"name":"Division of Diagnostic Imaging, Sheba Medical Center, Tel HaShomer, Israel."},{"name":"Faculty of Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moshe","family":"Bondi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel."},{"name":"Department of Neurological Rehabilitation, Sheba Medical Center, Tel HaShomer, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Zeilig","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel."},{"name":"Department of Neurological Rehabilitation, Sheba Medical Center, Tel HaShomer, Israel."},{"name":"School of Health Professions, Ono Academic College, Kiryat Ono, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Defrin","sequence":"additional","affiliation":[{"name":"Sagol Neuroscience School, Tel Aviv University, Tel Aviv, Israel."},{"name":"Department of Physical Therapy, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,4,4]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2018.04.018"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.2147\/jn.s143236"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1179\/2045772314Y.0000000194"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-018-0633-4"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg007"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(02)00452-9"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70251-0"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0304-3959(00)00369-9"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.01413"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2014.05.014"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhn072"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep18534"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2013.10.007"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhp205"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/2796571"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2011.156"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.PMR.2014.04.001"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(75)90044-5"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1006\/NIMG.2000.0582"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2007.01485"},{"key":"e_1_3_4_22_2","first-page":"3537","article-title":"ExploreDTI: A graphical toolbox for processing, analyzing, and visualizing diffusion MR data","volume":"17","author":"Leemans A","year":"2009","unstructured":"Leemans A, , Jeurissen B, , Sijbers J, et al. ExploreDTI: A graphical toolbox for processing, analyzing, and visualizing diffusion MR data. Proc Intl Soc Mag Reson Med, 2009; 17:3537.","journal-title":"Proc Intl Soc Mag Reson Med"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhp205"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2005.03.011"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2010.01637.x"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhq146"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.10.046"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/2796571"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2018.10.014"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.753"},{"issue":"1","key":"e_1_3_4_31_2","first-page":"184","article-title":"Herpes zoster chronification to postherpetic neuralgia induces brain activity and grey matter volume change","volume":"10","author":"Cao S","year":"2018","unstructured":"Cao S, , Qin B, , Zhang Y, et al. Herpes zoster chronification to postherpetic neuralgia induces brain activity and grey matter volume change. Am J Transl Res, 2018; 10(1):184\u2013199.","journal-title":"Am J Transl Res"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-017-0783-5"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhs378"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000226589.00599.4d"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3687-09.2009"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.03.049"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.02.029"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.5080\/u23484"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2020.107174"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.1159"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40122-020-00213-0"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/ner.13399"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-019-02357-z"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.38771"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.405"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-020-01159-6"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.JPAIN.2014.08.002"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-022-00690-1"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep36030"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEUBIOREV.2018.05.008"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24508"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23163"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.09.009"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2008.0683"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-811161-1.00007-4"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","unstructured":"DiProspero ND Kim S Yassa MA. Magnetic Resonance Imaging Biomarkers for Cognitive Decline in Down Syndrome. In: The Neurobiology of Aging and Alzheimer Disease in Down Syndrome. (Head E Lott I. eds.) Academic Press; 2022; pp. 149\u2013172; doi: 10.1016\/B978-0-12-818845-3.00014-1","DOI":"10.1016\/B978-0-12-818845-3.00014-1"}],"container-title":["Journal of Neurotrauma"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/neu.2023.0146","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/neu.2023.0146","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/neu.2023.0146","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:43:29Z","timestamp":1777675409000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/neu.2023.0146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":55,"journal-issue":{"issue":"7-8","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1089\/neu.2023.0146"],"URL":"https:\/\/doi.org\/10.1089\/neu.2023.0146","relation":{},"ISSN":["0897-7151","1557-9042"],"issn-type":[{"value":"0897-7151","type":"print"},{"value":"1557-9042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4]]}}}