{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T07:23:12Z","timestamp":1792480992764,"version":"4.5.0"},"reference-count":45,"publisher":"SAGE Publications","issue":"5-6","license":[{"start":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T00:00:00Z","timestamp":1708992000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:p>\n                    In this study, we investigated the effects of hinokitiol, a small-molecule natural compound, against neuronal ferroptosis after traumatic brain injury (TBI). A controlled cortical impact (CCI) mouse model and excess glutamate-treated HT-22 cells were used to study the effects of hinokitiol on TBI. Hinokitiol mitigated TBI brain tissue lesions and significantly improved neurological function. Neuron loss and iron deposition were ameliorated after hinokitiol administration. Hinokitiol alleviated excessive glutamate-induced intracellular reactive oxygen species (ROS), lipid peroxidation, and Fe\n                    <jats:sup>2+<\/jats:sup>\n                    accumulation in HT-22. Mechanistically, hinokitiol upregulated heme oxygenase-1 (HO-1) expression, promoted nuclear factor-erythroid factor 2-related factor 2 (Nrf2) nuclear translocation, and inhibited the activation of microglia and astrocyte after TBI. These results suggest that hinokitiol has neuroprotective effects on rescuing cells from TBI-induced neuronal ferroptosis. In summary, hinokitiol is a potential therapeutic candidate for TBI by activating the Nrf2\/Keap1\/HO-1 signaling pathway.\n                  <\/jats:p>","DOI":"10.1089\/neu.2023.0150","type":"journal-article","created":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T08:08:59Z","timestamp":1699949339000},"page":"734-750","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":30,"title":["Protective Effects of Hinokitiol on Neuronal Ferroptosis by Activating the Keap1\/Nrf2\/HO-1 Pathway in Traumatic Brain Injury"],"prefix":"10.1177","volume":"41","author":[{"given":"Hongxing","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kejun","family":"He","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weichi","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weilin","family":"Jin","sequence":"additional","affiliation":[{"name":"Institute of Cancer Neuroscience, Medical Frontier Innovation Research Center, The First Hospital of Lanzhou University, The First Clinical Medical College of Lanzhou University, Lanzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixuan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoshu","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,2,27]]},"reference":[{"key":"e_1_3_7_2_2","first-page":"1759","article-title":"Changing patterns in the epidemiology of traumatic brain injury","author":"Roozenbeek B","year":"2013","unstructured":"Roozenbeek B, , Maas Ai Fau-Menon DK, , Menon DK. 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