{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:10:14Z","timestamp":1787008214144,"version":"build-2736575974"},"reference-count":60,"publisher":"SAGE Publications","issue":"17-18","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:p>\n                    Brief exposure to repeated episodes of low inspired oxygen, or acute intermittent hypoxia (AIH), is a promising therapeutic modality to improve motor function after chronic, incomplete spinal cord injury (SCI). Although therapeutic AIH is under extensive investigation in persons with SCI, limited data are available concerning cardiorespiratory responses during and after AIH exposure despite implications for AIH safety and tolerability. Thus, we recorded immediate (during treatment) and enduring (up to 30\u2009min post-treatment) cardiorespiratory responses to AIH in 19 participants with chronic SCI (&gt;1 year post-injury; injury levels C1 to T6; American Spinal Injury Association Impairment Scale A to D; mean age\u2009=\u200933.8\u2009\u00b1\u200914.1 years; 18 males). Participants completed a single AIH (15, 60-sec episodes, inspired O\n                    <jats:sub>2<\/jats:sub>\n                    \u2248 10%; 90-sec intervals breathing room air) and Sham (inspired O\n                    <jats:sub>2<\/jats:sub>\n                    \u2248 21%) treatment, in random order. During hypoxic episodes: (1) arterial oxyhemoglobin saturation decreased to 82.1\u2009\u00b1\u20092.9% (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001); (2) minute ventilation increased 3.83\u2009\u00b1\u20092.29\u2009L\/min (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.008); and (3) heart rate increased 4.77\u2009\u00b1\u20096.82\u2009bpm (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.010). Considerable variability in cardiorespiratory responses was found among subjects; some individuals exhibited large hypoxic ventilatory responses (\u22650.20\u2009L\/min\/%,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200911), whereas others responded minimally (&lt;0.20\u2009L\/min\/%,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u20098). Apneas occurred frequently during AIH and\/or Sham protocols in multiple participants. All participants completed AIH treatment without difficulty. No significant changes in ventilation, heart rate, or arterial blood pressure were found 30\u2009min post-AIH\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&gt;\u20090.05). In conclusion, therapeutic AIH is well tolerated, elicits variable chemoreflex activation, and does not cause persistent changes in cardiorespiratory control\/function 30\u2009min post-treatment in persons with chronic SCI.\n                  <\/jats:p>","DOI":"10.1089\/neu.2023.0353","type":"journal-article","created":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T03:05:11Z","timestamp":1710212711000},"page":"2114-2124","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Cardiorespiratory Responses to Acute Intermittent Hypoxia in Humans With Chronic Spinal Cord Injury"],"prefix":"10.1177","volume":"41","author":[{"given":"Joseph F.","family":"Welch","sequence":"first","affiliation":[{"name":"Breathing Research and Therapeutics Center and Department of Physical Therapy, University of Florida, Gainesville, Florida, USA."},{"name":"McKnight Brain Institute, University of Florida, Gainesville, Florida, USA."},{"name":"School of Sport, Exercise and Rehabilitation Sciences, College of Life and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia K.","family":"Vose","sequence":"additional","affiliation":[{"name":"Breathing Research and Therapeutics Center and Department of Physical Therapy, University of Florida, Gainesville, Florida, USA."},{"name":"McKnight Brain Institute, University of Florida, Gainesville, Florida, USA."},{"name":"Brooks Rehabilitation, Jacksonville, Florida, USA."},{"name":"Department of Neurology, College of Medicine\u2013Jacksonville, University of Florida, Jacksonville, Florida, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Cavka","sequence":"additional","affiliation":[{"name":"Brooks Rehabilitation, Jacksonville, Florida, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina","family":"Brunetti","sequence":"additional","affiliation":[{"name":"Brooks Rehabilitation, Jacksonville, Florida, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis A.","family":"DeMark","sequence":"additional","affiliation":[{"name":"Brooks Rehabilitation, Jacksonville, Florida, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Snyder","sequence":"additional","affiliation":[{"name":"Brooks Rehabilitation, Jacksonville, Florida, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clayton N.","family":"Wauneka","sequence":"additional","affiliation":[{"name":"Brooks Rehabilitation, Jacksonville, Florida, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geneva","family":"Tonuzi","sequence":"additional","affiliation":[{"name":"Brooks Rehabilitation, Jacksonville, Florida, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayakrishnan","family":"Nair","sequence":"additional","affiliation":[{"name":"Breathing Research and Therapeutics Center and Department of Physical Therapy, University of Florida, Gainesville, Florida, USA."},{"name":"McKnight Brain Institute, University of Florida, Gainesville, Florida, USA."},{"name":"Department of Physical Therapy, Thomas Jefferson University, Philadelphia, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon S.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Breathing Research and Therapeutics Center and Department of Physical Therapy, University of Florida, Gainesville, Florida, USA."},{"name":"McKnight Brain Institute, University of Florida, Gainesville, Florida, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily J.","family":"Fox","sequence":"additional","affiliation":[{"name":"Breathing Research and Therapeutics Center and Department of Physical Therapy, University of Florida, Gainesville, Florida, USA."},{"name":"Brooks Rehabilitation, Jacksonville, Florida, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,9,17]]},"reference":[{"key":"e_1_3_6_2_2","unstructured":"Daly MdB. Interactions between respiration and circulation. In: Handbook of Physiology Section 3. (Cherniack NS Widdicombe JG. eds.). American Physiological Society: Bethesda MD; 1986"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2004.03.016"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2021.113891"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/1545968311412055"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2021.113735"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00088.2015"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201305-0848OC"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000437416.34298.43"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2016.4478"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004596"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2016.09.114"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2021.113709"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1113\/JP282822"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2021.113651"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1113\/EP090099"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2018-313585"},{"key":"e_1_3_6_18_2","doi-asserted-by":"publisher","DOI":"10.1183\/20734735.012616"},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201908-1590ST"},{"key":"e_1_3_6_20_2","unstructured":"Hinkle DE Wiersma W Jurs SG. Applied Statistics for the Behavioral Sciences. Houghton Mifflin: Boston MA; 2003"},{"issue":"4","key":"e_1_3_6_21_2","first-page":"R811","article-title":"Time-dependent phrenic nerve responses to carotid afferent activation: intact vs. decerebrate rats","volume":"265","author":"Hayashi F","year":"1993","unstructured":"Hayashi F, , Coles SK, , Bach KB, et al. Time-dependent phrenic nerve responses to carotid afferent activation: intact vs. decerebrate rats. Am J Physiol, 1993; 265(4 pt 2):R811\u2013R819","journal-title":"Am J Physiol"},{"key":"e_1_3_6_22_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1996.sp021158"},{"key":"e_1_3_6_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1166"},{"key":"e_1_3_6_24_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-14-06239.2002"},{"key":"e_1_3_6_25_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.90.5.2001"},{"key":"e_1_3_6_26_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1913.sp001616"},{"key":"e_1_3_6_27_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4122-15.2016"},{"key":"e_1_3_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-91534-2.00016-3"},{"key":"e_1_3_6_29_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00197.2023"},{"key":"e_1_3_6_30_2","first-page":"58","article-title":"The impact of intermittent or sustained carbon dioxide on intermittent hypoxia initiated respiratory plasticity","volume":"256","author":"Mateika JH","year":"2018","unstructured":"Mateika JH, , Panza GS, , Alex R, et al. The impact of intermittent or sustained carbon dioxide on intermittent hypoxia initiated respiratory plasticity. What is the effect of these combined stimuli on apnea severity? Respir Physiol Neurobiol, 2018; 256:58\u201366","journal-title":"What is the effect of these combined stimuli on apnea severity? Respir Physiol Neurobiol"},{"key":"e_1_3_6_31_2","doi-asserted-by":"publisher","DOI":"10.1113\/JP281129"},{"key":"e_1_3_6_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2021.08.015"},{"key":"e_1_3_6_33_2","doi-asserted-by":"publisher","DOI":"10.1113\/JP277711"},{"key":"e_1_3_6_34_2","doi-asserted-by":"publisher","DOI":"10.1053\/mr.2000.3848"},{"key":"e_1_3_6_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29066-1"},{"issue":"4","key":"e_1_3_6_36_2","first-page":"433","article-title":"Exercise responses and quadriplegia","volume":"25","author":"Figoni SF","year":"1993","unstructured":"Figoni SF. Exercise responses and quadriplegia. Med Sci Sports Exerc, 1993; 25(4):433\u2013441","journal-title":"Med Sci Sports Exerc"},{"issue":"4","key":"e_1_3_6_37_2","first-page":"423","article-title":"Exercise capacity of individuals with paraplegia","volume":"25","author":"Davis GM","year":"1993","unstructured":"Davis GM. Exercise capacity of individuals with paraplegia. Med Sci Sports Exerc, 1993; 25(4):423\u2013432","journal-title":"Med Sci Sports Exerc"},{"key":"e_1_3_6_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.sc.3101855"},{"key":"e_1_3_6_39_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00261.2022"},{"key":"e_1_3_6_40_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00021.2023"},{"key":"e_1_3_6_41_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.091462"},{"key":"e_1_3_6_42_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.152108"},{"key":"e_1_3_6_43_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202108-1808OC"},{"key":"e_1_3_6_44_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.897978"},{"key":"e_1_3_6_45_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00135.2002"},{"key":"e_1_3_6_46_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1996.81.2.866"},{"key":"e_1_3_6_47_2","first-page":"A260","article-title":"Ventilatory responses to repetitive hypoxia in normal males","volume":"149","author":"Stewart D","year":"1994","unstructured":"Stewart D, , Berthon-Jones M, , McNamara SG, et al. Ventilatory responses to repetitive hypoxia in normal males. Am J Respir Crit Care Med, 1994; 149:A260","journal-title":"Am J Respir Crit Care Med"},{"key":"e_1_3_6_48_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00896.2005"},{"key":"e_1_3_6_49_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01273.2007"},{"key":"e_1_3_6_50_2","doi-asserted-by":"publisher","DOI":"10.1113\/JP280458"},{"key":"e_1_3_6_51_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00043.2008"},{"key":"e_1_3_6_52_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00506.2003"},{"key":"e_1_3_6_53_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1995.79.1.205"},{"key":"e_1_3_6_54_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.91.4.1555"},{"key":"e_1_3_6_55_2","first-page":"675","article-title":"Physiological responses to two hypoxic conditioning strategies in healthy subjects","volume":"7","author":"Chacaroun S","year":"2016","unstructured":"Chacaroun S, , Borowik A, , Morrison SA, et al. Physiological responses to two hypoxic conditioning strategies in healthy subjects. Front Physiol, 2016; 7:675","journal-title":"Front Physiol"},{"key":"e_1_3_6_56_2","doi-asserted-by":"publisher","DOI":"10.1080\/10790268.2016.1142137"},{"key":"e_1_3_6_57_2","doi-asserted-by":"publisher","DOI":"10.1113\/JP278941"},{"key":"e_1_3_6_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2023.114478"},{"key":"e_1_3_6_59_2","unstructured":"Center NSCIS. Traumatic Spinal Cord Injury Facts and Figures at a Glance. University of Alabama at Birmingham: Birmingham AL; 2023"},{"key":"e_1_3_6_60_2","doi-asserted-by":"publisher","DOI":"10.1093\/function\/zqad026"},{"key":"e_1_3_6_61_2","doi-asserted-by":"publisher","DOI":"10.1177\/1545968319872992"}],"container-title":["Journal of Neurotrauma"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/neu.2023.0353","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/neu.2023.0353","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/neu.2023.0353","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:44:01Z","timestamp":1777675441000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/neu.2023.0353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":60,"journal-issue":{"issue":"17-18","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1089\/neu.2023.0353"],"URL":"https:\/\/doi.org\/10.1089\/neu.2023.0353","relation":{},"ISSN":["0897-7151","1557-9042"],"issn-type":[{"value":"0897-7151","type":"print"},{"value":"1557-9042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9]]}}}