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Seventy-nine adult male Institute of Cancer Research (ICR) mice were subjected to either a sham procedure or closed-head mTBI using the weight-drop model. Seven days post-injury, separate cohorts of mice underwent either a non-cognitive or a cognitive home cage assessment, a treadmill fatigue test, or the Open Field Test. mTBI significantly influenced habituation behavior and circadian wheel-running activity. Notably, mTBI mice exhibited an increased frequency of visits to the running wheel, but each visit was shorter than those of controls. No significant differences between the groups in discrimination or reversal learning performance were observed. However, during the reversal learning stage, mTBI mice performed similarly to their initial discrimination learning levels, suggesting an abnormally faster rate of reversal learning. Home cage monitoring is a valuable tool for studying the subtle effects of mTBI, complementing traditional assays. The automated evaluation of habituation to novel stimuli (e.g., novel environment) could serve as a potentially sensitive tool for assessing mTBI-associated behavioral deficits.<\/jats:p>","DOI":"10.1089\/neu.2023.0459","type":"journal-article","created":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T08:01:56Z","timestamp":1711094516000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Investigation of Mild Traumatic Brain Injury Home Cage Behavior: The Home Cage Assay Advantages"],"prefix":"10.1177","volume":"41","author":[{"given":"Bar","family":"Richmond-Hacham","sequence":"first","affiliation":[{"name":"Department of Anatomy and Anthropology, Tel Aviv University Faculty of Medicine, Tel Aviv, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liron","family":"Tseitlin","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Anthropology, Tel Aviv University Faculty of Medicine, Tel Aviv, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lior","family":"Bikovski","sequence":"additional","affiliation":[{"name":"Myers Neuro-Behavioral Core Facility, Tel Aviv University Faculty of Medicine, Tel Aviv, Israel."},{"name":"School of Behavioral Sciences, Netanya Academic College, Netanya, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaim G.","family":"Pick","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Anthropology, Tel Aviv University Faculty of Medicine, Tel Aviv, Israel."},{"name":"Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel."},{"name":"Sylvan Adams Sports Institute, Tel Aviv University, Tel Aviv, Israel."},{"name":"Dr. Miriam and Sheldon G. 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