{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:44:45Z","timestamp":1777927485596,"version":"3.51.4"},"reference-count":44,"publisher":"SAGE Publications","issue":"15-16","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:p>\n                    In the past decade, signature clinical neuropathology of blast-induced traumatic brain injury has been under intense debate, but interface astroglial scarring (IAS) seems to be convincing. In this study, we examined whether IAS could be replicated in the rat brain exposed to a laser-induced shock wave(s) (LISW[s]), a tool that can produce a pure shock wave (primary mechanism) without dynamic pressure (tertiary mechanism). Under certain conditions, we observed astroglial scarring in the subpial glial plate (SGP), gray-white matter junctions (GM-WM), ventricular wall (VW), and regions surrounding cortical blood vessels, accurately reproducing clinical IAS. We also observed shock wave impulse-dependent meningeal damage (dural microhemorrhage)\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    by transcranial near-infrared (NIR) reflectance imaging. Importantly, there were significant correlations between the degree of dural microhemorrhage and the extent of astroglial scarring more than 7 days post-exposure, suggesting an association of meningeal damage with astroglial scarring. The results demonstrated that the primary mechanism alone caused the IAS and meningeal damage, both of which are attributable to acoustic impedance mismatching at multi-layered tissue boundaries. The time course of glial fibrillary acidic protein (GFAP) immunoreactivity depended not only on the LISW conditions but also on the regions. In the SGP, significant increases in GFAP immunoreactivity were observed at 3 days post-exposure, whereas in the GM-WM and VW, GFAP immunoreactivity was not significantly increased before 28 days post-exposure, suggesting different pathological mechanisms. With the high-impulse single exposure or the multiple exposure (low impulse), fibrotic reaction or fibrotic scar formation was observed, in addition to astroglial scarring, in the cortical surface region. Although there are some limitations, this seems to be the first report on the shock-wave-induced IAS rodent model. The model may be useful to explore potential therapeutic approaches for IAS.\n                  <\/jats:p>","DOI":"10.1089\/neu.2023.0572","type":"journal-article","created":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T09:20:30Z","timestamp":1711531230000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Meningeal Damage and Interface Astroglial Scarring in the Rat Brain Exposed to a Laser-Induced Shock Wave(s)"],"prefix":"10.1177","volume":"41","author":[{"given":"Satoko","family":"Kawauchi","sequence":"first","affiliation":[{"name":"Division of Bioinformation and Therapeutic Systems, National Defense Medical College Research Institute, Tokorozawa, Saitama, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akemi","family":"Kono","sequence":"additional","affiliation":[{"name":"Division of Bioinformation and Therapeutic Systems, National Defense Medical College Research Institute, Tokorozawa, Saitama, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuriko","family":"Muramatsu","sequence":"additional","affiliation":[{"name":"Division of Bioinformation and Therapeutic Systems, National Defense Medical College Research Institute, Tokorozawa, Saitama, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grant","family":"Hennes","sequence":"additional","affiliation":[{"name":"Defence Research and Development Canada, Suffield Research Centre, Medicine Hat, Alberta, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuta","family":"Seki","sequence":"additional","affiliation":[{"name":"Pharmacy Selection, Medical Material Department, Japan Self Defense Force Central Hospital, Setagaya, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Tominaga","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasue","family":"Haruyama","sequence":"additional","affiliation":[{"name":"Division of Bioinformation and Therapeutic Systems, National Defense Medical College Research Institute, Tokorozawa, Saitama, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukari","family":"Komuta","sequence":"additional","affiliation":[{"name":"Division of Bioinformation and Therapeutic Systems, National Defense Medical College Research Institute, Tokorozawa, Saitama, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izumi","family":"Nishidate","sequence":"additional","affiliation":[{"name":"Division of Bioinformation and Therapeutic Systems, National Defense Medical College Research Institute, Tokorozawa, Saitama, Japan."},{"name":"Graduate School of Bio-Applications and Systems Engineering, Tokyo University of Agriculture and Technology, Koganei, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Matsukuma","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yushan","family":"Wang","sequence":"additional","affiliation":[{"name":"Defence Research and Development Canada, Suffield Research Centre, Medicine Hat, Alberta, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunichi","family":"Sato","sequence":"additional","affiliation":[{"name":"Division of Bioinformation and Therapeutic Systems, National Defense Medical College Research Institute, Tokorozawa, Saitama, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,8,20]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)30057-6"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003716"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2203199"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac298"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1121\/1.1349183"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2010.1442"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2011.2224"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70161-3"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.547655"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlaa157"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.243558"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0082891"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.24.3.035005"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2022.0101"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.25172"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/jramc-147-01-02"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra042083"},{"key":"e_1_3_4_19_2","unstructured":"NATO Human Factors and Medicine (HFM) Research Task Group (RTG) Final Report of Task Group HFM-270 Framework for Modeling and Simulation of Human Lethality Injury and Impairment from Blast-Related Threats. Science and Technology Organization North Atlantic Treaty Organization. Neuilly-sur-Seine. Cedex France; 2023."},{"key":"e_1_3_4_20_2","unstructured":"U.S. Department of Defense Blast Injury Research Coordinating Office. What is Blast Injury? Available from: https:\/\/blastinjuryresearch.health.mil\/index.cfm\/blast_injury_101\/what_is_blast_injury"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0161597"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00052"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2009.203"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-13826-6"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2023.0328"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14634"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2018.04.003"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2015.00072"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep26992"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-012-1336-5"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.1993.10.167"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03438.x"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2007.06.009"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(96)10047-3"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-021-00525-w"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.688254"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2020.07.004"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2023.103848"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3550"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2022.104987"},{"key":"e_1_3_4_41_2","volume-title":"MSME Thesis, Purdue University, West Lafayette, Indiana","author":"Alley M.","year":"2009","unstructured":"Alley M. Explosive blast loading experiments for TBI scenarios: characterization and mitigation. MSME Thesis, Purdue University, West Lafayette, Indiana. UMI Microform 1470126 distributed by ProQuest LLC: Ann Arbor, MI; 2009."},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.05.025"},{"key":"e_1_3_4_43_2","article-title":"Lethal and physical injury of marine mammals, and requirements for passive acoustic monitoring","author":"Parvin SJ","year":"2007","unstructured":"Parvin SJ, , Nedwell JR, , Harland E. 2007. Lethal and physical injury of marine mammals, and requirements for passive acoustic monitoring. (Report No. 565R0212). Report by Subacoustech Ltd. Report for U.K. Department of Trade and Industry (DTI).","journal-title":"Report for U.K. Department of Trade and Industry (DTI)"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.21236\/AD0693105"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-021-03554-0"}],"container-title":["Journal of Neurotrauma"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/neu.2023.0572","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/neu.2023.0572","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/neu.2023.0572","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:44:48Z","timestamp":1777675488000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/neu.2023.0572"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":44,"journal-issue":{"issue":"15-16","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1089\/neu.2023.0572"],"URL":"https:\/\/doi.org\/10.1089\/neu.2023.0572","relation":{},"ISSN":["0897-7151","1557-9042"],"issn-type":[{"value":"0897-7151","type":"print"},{"value":"1557-9042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8]]}}}