{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:44:34Z","timestamp":1777927474034,"version":"3.51.4"},"reference-count":41,"publisher":"SAGE Publications","issue":"17-18","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neurotrauma"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:p>\n                    Diffusion-weighted magnetic resonance imaging (DW-MRI) is a promising technique for assessing spinal cord injury (SCI) that has historically been challenged by the presence of metallic stabilization hardware. This study leverages recent advances in metal-artifact resistant multi-spectral DW-MRI to enable diffusion quantification throughout the spinal cord even after fusion stabilization. Twelve participants with cervical spinal cord injuries treated with fusion stabilization and 49 asymptomatic able-bodied control participants underwent multi-spectral DW-MRI evaluation. Apparent diffusion coefficient (ADC) values were calculated in axial cord sections. Statistical modeling assessed ADC differences across cohorts and within distinct cord regions of the SCI participants (at, above, or below injured level). Computed models accounted for subject demographics and injury characteristics. ADC was found to be elevated at injured levels compared with non-injured levels (z\u2009=\u20093.2,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.001), with ADC at injured levels decreasing over time since injury (z\u2009=\u2009-9.2,\n                    <jats:italic toggle=\"yes\">p &lt;<\/jats:italic>\n                    0.001). Below the injury level, ADC was reduced relative to controls (z\u2009=\u2009-4.4,\n                    <jats:italic toggle=\"yes\">p &lt;<\/jats:italic>\n                    0.001), with greater reductions after more severe injuries that correlated with lower extremity motor scores (z\u2009=\u20092.56,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.012). No statistically significant differences in ADC above the level of injury were identified. By enabling diffusion analysis near fusion hardware, the multi-spectral DW-MRI technique allowed intuitive quantification of cord diffusion changes after SCI both at and away from injured levels. This demonstrates the approach's potential for assessing post-surgical spinal cord integrity throughout stabilized regions.\n                  <\/jats:p>","DOI":"10.1089\/neu.2023.0591","type":"journal-article","created":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T07:19:48Z","timestamp":1705907988000},"page":"2125-2132","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Diffusion Weighted Magnetic Resonance Imaging of Spinal Cord Injuries After Instrumented Fusion Stabilization"],"prefix":"10.1177","volume":"41","author":[{"given":"Kevin M.","family":"Koch","sequence":"first","affiliation":[{"name":"Department of Radiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew S.","family":"Nencka","sequence":"additional","affiliation":[{"name":"Department of Radiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shekar","family":"Kurpad","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew D.","family":"Budde","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,9,17]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0000000000004417"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2011-300504.22"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2016.4901"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.3171\/2019.1.FOCUS18591"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.25259\/SNI_508_2020"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.sc.3102007"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2594(200012)44:6<884::AID-MRM9>3.0.CO;2-Q"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2013.09.017"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005258"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21856"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21967"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22523"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25321"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26737"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.29153"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/hec.4120"},{"key":"e_1_3_6_18_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1172833"},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2018.04.001"},{"key":"e_1_3_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.10.009"},{"key":"e_1_3_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.09.081"},{"key":"e_1_3_6_22_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/719520"},{"key":"e_1_3_6_23_2","first-page":"0187","article-title":"PAM50: multimodal template of the brainstem and spinal cord compatible with the ICBM152 space","author":"DeLeener B","year":"2017","unstructured":"DeLeener B, , Fonov V, , Collins DL, et al. 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