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Although clinical guidelines recommend maintaining the mean arterial pressure within 85\u201390 mmHg during the first week of injury, there is no pre-clinical evidence from animal models to prove the therapeutic efficacy of hemodynamic management. Accordingly, the present study was designed to investigate the therapeutic efficacy of hemodynamic management in rats with cervical spinal cord contusion. Adult male rats underwent cervical spinal cord contusion and the implantation of osmotic pumps filled with saline or norepinephrine (NE) (125 \u03bcg\/(kg\u00b7h) for 1 week). The cardiorespiratory function of unanesthetized rats was examined using a non-invasive blood pressure analyzer and double-chamber plethysmography. Cervical spinal cord contusion caused a long-term reduction in the mean arterial pressure and tidal volume. This hypotensive response was significantly reversed in contused rats receiving NE (1 day: 88 \u00b1 19 mmHg; 2 weeks: 96 \u00b1 13 mmHg) compared with contused rats receiving saline (1 day: 72 \u00b1 15 mmHg; 2 weeks: 82 \u00b1 10 mmHg). NE also significantly improved the tidal volume 1 day post-injury (contused + NE: 0.7 \u00b1 0.2 mL; contused + saline: 0.5 \u00b1 0.1 mL). Immunofluorescence staining results revealed that injury-induced reductions of noradrenergic and glutamatergic fibers within the thoracic spinal cord were significantly improved by NE. These results provided the evidence demonstrating that hemodynamic management using NE significantly improves cardiorespiratory function by alleviating neural pathway damage after cervical spinal cord contusion.<\/jats:p>","DOI":"10.1089\/neu.2024.0342","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T16:39:43Z","timestamp":1733935183000},"page":"197-211","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Therapeutic Efficacy of Hemodynamic Management Using Norepinephrine on Cardiorespiratory Function Following Cervical Spinal Cord Contusion in Rats"],"prefix":"10.1177","volume":"42","author":[{"given":"Rui-Yi","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, College of Science, National Sun Yat-sen University, Kaohsiung, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5654-6502","authenticated-orcid":false,"given":"Kun-Ze","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, College of Science, National Sun Yat-sen University, Kaohsiung, Taiwan."},{"name":"Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,2,17]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.11024"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0006-8993(01)03388-1"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2009.08.007"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-91534-2.00012-6"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1113\/JP272287"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2022.05.016"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2017.5128"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00721.2019"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01104.2017"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2023.114478"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1424\/5\/ns.2040144.072"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-199312000-00008"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2014.3778"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2016.08.053"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2017.52"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.neu.0000430319.32247.7f"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/21925682231202348"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1424\/5\/ns.2121077.075"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2013.3061"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0000000000000638"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2017.5285"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18905-8"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1177\/028418517601700301"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1268\/8\/f1000research.11633.1"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2021.0403"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.4103\/EJPI.EJPI-D-23-00003"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00473.2023"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1177\/1545968316680494"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-016-0509-4"},{"issue":"9","key":"e_1_3_4_31_2","first-page":"509","article-title":"Total body water and its distribution in men with spinal cord injury","volume":"65","author":"Cardus D","year":"1984","unstructured":"Cardus D, , McTaggart WG. 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