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This secondary analysis of data from a randomized controlled trial included 513 adults presenting to emergency departments\/urgent care centers. Candidate predictors were demographic, injury-related and health history information collected during medical chart review and eligibility screening, and scores on questionnaires completed at 2 weeks postinjury. The primary outcome was presence\/absence of new or worsened major depressive disorder, anxiety disorders, and post-traumatic stress disorder (PTSD), determined with a structured psychodiagnostic interview (Mini International Neuropsychiatric Interview) at 3 and 6 months after mTBI. Logistic regression assessed the prognostic value of 22 pre-, peri-, and early postinjury factors. Least absolute shrinkage and selection operator (LASSO) was used to select predictors in prognostic model development. Younger age, identifying as a person of color, prior mTBI(s), maladaptive illness perceptions, and greater PTSD, and depression and anxiety symptom severity measured at 2 weeks postinjury were significant predictors of new\/worsened mental health complications 3\u20136 months following mTBI. A comprehensive model (with 9 LASSO-selected predictors) showed strong discriminability for predicting mental health complications (optimism-corrected area under the receiver operating characteristic curve [AUC] = 0.80), outperforming a basic model that included only variables commonly collected as part of usual clinical care (optimism-corrected AUC = 0.71). Certain pre-injury and demographic characteristics are associated with increased risk of mental health complications after mTBI. Assessing for early postinjury illness beliefs and psychological symptoms can further improve prognostic accuracy.<\/jats:p>","DOI":"10.1089\/neu.2024.0505","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T03:38:47Z","timestamp":1748230727000},"page":"1359-1370","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Prediction of Mental Health Complications Following Mild Traumatic Brain Injury"],"prefix":"10.1177","volume":"42","author":[{"given":"Shuyuan","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Psychology, University of British Columbia, Vancouver, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Mikoli\u0107","sequence":"additional","affiliation":[{"name":"Erasmus MCPublic Health Rotterdam, Rotterdam, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joelle","family":"LeMoult","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of British Columbia, Vancouver, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Rights","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of British Columbia, Vancouver, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Panenka","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of British Columbia, Vancouver, Canada."},{"name":"BC Mental Health and Substance Use Services Research Institute, Vancouver, Canada."},{"name":"Djavad Mowafaghian Centre for Brain Health, Vancouver, Canada."},{"name":"UBC Institute of Mental Health, Vancouver, Canada."},{"name":"BC Provincial Neuropsychiatry Program, Vancouver, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noah D.","family":"Silverberg","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of British Columbia, Vancouver, Canada."},{"name":"Rehabilitation Research Program, Centre for Aging SMART at Vancouver Coastal Health, Vancouver, Canada."},{"name":"Djavad Mowafaghian Centre for Brain Health, Vancouver, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,8,14]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.neuropsych.21080207"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2018.6172"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/pmrj.12657"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.2010.22.1.100"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1037\/rep0000422"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2018.5759"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.psy.44.1.31"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2009.09050617"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-035527"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2018.4288"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00639"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.62.5.523"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2014.3600"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30117-5"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2022.0320"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.neuropsych.16090165"},{"key":"e_1_3_6_18_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2015.4252"},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/09638288.2018.1424957"},{"key":"e_1_3_6_20_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.neuropsych.20220073"},{"key":"e_1_3_6_21_2","doi-asserted-by":"publisher","DOI":"10.1080\/09658211.2012.758419"},{"key":"e_1_3_6_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2022-062527"},{"key":"e_1_3_6_23_2","doi-asserted-by":"publisher","DOI":"10.1080\/16501970510027321"},{"key":"e_1_3_6_24_2","first-page":"22","article-title":"The mini-international neuropsychiatric interview (MINI): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10","volume":"59","author":"Sheehan D","year":"1998","unstructured":"Sheehan D, , Lecrubier Y, , Sheehan H, et al. 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