{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T22:10:07Z","timestamp":1783807807738,"version":"3.55.0"},"reference-count":55,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T00:00:00Z","timestamp":1660003200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T00:00:00Z","timestamp":1660003200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Neurotrauma Reports"],"published-print":{"date-parts":[[2022,9,1]]},"abstract":"<jats:title>\n                    <jats:bold>Abstract<\/jats:bold>\n                  <\/jats:title>\n                  <jats:p>\n                    Cortical gyrification, as a specific measure derived from magnetic resonance imaging, remains understudied in mild traumatic brain injury (mTBI). Local gyrification index (\n                    <jats:italic toggle=\"yes\">l<\/jats:italic>\n                    GI) and mean curvature are related measures indexing the patterned folding of the cortex,ml which reflect distinct properties of cortical morphology and geometry. Using both metrics, we examined cortical gyrification morphology in 59 adult males with mTBI (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200929) versus those without (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200930) mTBI in the subacute phase of injury (between 2 weeks and 3 months). The effect of IQ on\n                    <jats:italic toggle=\"yes\">l<\/jats:italic>\n                    GI and brain-symptom relations were also examined. General linear models revealed greater\n                    <jats:italic toggle=\"yes\">l<\/jats:italic>\n                    GI in mTBI versus controls in the frontal lobes bilaterally, but reduced\n                    <jats:italic toggle=\"yes\">l<\/jats:italic>\n                    GI in mTBI of the left temporal lobe. An age-related decrease in\n                    <jats:italic toggle=\"yes\">l<\/jats:italic>\n                    GI was found in numerous areas, with no significant group-by-age interaction effects observed. Including other factors (i.e., mTBI severity, symptoms, and IQ) in the\n                    <jats:italic toggle=\"yes\">l<\/jats:italic>\n                    GI model yielded similar results with few exceptions. Mean curvature analyses depicted a significant group-by-age interaction with the absence of significant main effects of group or age. Our results suggest that cortical gyrification morphology is adversely affected by mTBI in both frontal and temporal lobes, which are thought of as highly susceptible regions to mTBI. These findings contribute to understanding the effects of mTBI on neuromorphological properties, such as alterations in cortical gyrification, which reflect underlying microstructural changes (i.e., apoptosis, neuronal number, or white matter alterations). Future studies are needed to infer causal relationships between micro- and macrostructural changes after an mTBI and investigate potential sex differences.\n                  <\/jats:p>","DOI":"10.1089\/neur.2021.0032","type":"journal-article","created":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T10:46:10Z","timestamp":1660214770000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Cortical Gyrification Morphology in Adult Males with Mild Traumatic Brain Injury"],"prefix":"10.1177","volume":"3","author":[{"given":"Avideh","family":"Gharehgazlou","sequence":"first","affiliation":[{"name":"Neurosciences and Mental Health, The Hospital for Sick Children (SickKids) Research Institute, Toronto, Ontario, Canada."},{"name":"Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh","family":"Jetly","sequence":"additional","affiliation":[{"name":"Directorate of Mental Health, Canadian Forces Health Services HQ, Ottawa, Ontario, Canada."},{"name":"Defence Research and Development Canada\u2013Toronto Research Centre, Toronto, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn G.","family":"Rhind","sequence":"additional","affiliation":[{"name":"Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, Ontario, Canada."},{"name":"Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy C.","family":"Reichelt","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, South Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leodante","family":"Da Costa","sequence":"additional","affiliation":[{"name":"Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada."},{"name":"Department of Surgery, University of Toronto, Toronto, Ontario, Canada."},{"name":"Department of Diagnostic Imaging, The Hospital for Sick Children (SickKids) Research Institute, Toronto, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin T.","family":"Dunkley","sequence":"additional","affiliation":[{"name":"Neurosciences and Mental Health, The Hospital for Sick Children (SickKids) Research Institute, Toronto, Ontario, Canada."},{"name":"Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada."},{"name":"Department of Diagnostic Imaging, The Hospital for Sick Children (SickKids) Research Institute, Toronto, Ontario, Canada."},{"name":"Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,8,9]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/16501960410023732"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/16501960410023877"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.3810\/psm.2002.02.176"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.7.1253"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.158.15.1617"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(74)91639-0"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/acp006"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2012-302742"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2013.12.009"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2017.04.026"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2014.11.016"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2016.01.003"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2019.6698"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410010109"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3976-13.2014"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0054-11.2011"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-00582-1"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhs231"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.15039"},{"key":"e_1_3_5_21_2","author":"Lamballais S.","unstructured":"Lamballais S., , Vinke E.J., , Vernooij M.W., , Ikram M.A., , and Muetzel R.L (2020). 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