{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T10:21:08Z","timestamp":1783592468456,"version":"3.55.0"},"reference-count":30,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T00:00:00Z","timestamp":1657843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T00:00:00Z","timestamp":1657843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Neurotrauma Reports"],"published-print":{"date-parts":[[2022,9,1]]},"abstract":"<jats:p>\n                    Therapeutic hypothermia for severe traumatic brain injury (TBI) has been repeatedly studied, but no past studies have assessed the detailed head computed tomography (CT) findings. We sought to investigate individual CT findings of severe TBI patients treated with targeted temperature management utilizing the head CT database obtained from the Brain Hypothermia study. Enrolled patients underwent either mild therapeutic hypothermia (32.0\u00b0C\u221234.0\u00b0C) or fever control (35.5\u00b0C\u221237.0\u00b0C). We assessed individual head CT images on arrival and after rewarming and investigated the correlations with outcomes. The initial CT data were available for 125 patients (hypothermia group\u2009=\u200980, fever control group\u2009=\u200945). Baseline characteristics and CT findings, such as hematoma thickness and midline shift, were similar in all aspects between the two groups. The favorable outcomes in the hypothermia and fever control groups were 38 (47.5%) and 24 (53.3%;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.53) for all 125 patients, respectively; 21 (46.7%) vs. 10 (38.5%;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.50) for 71 patients with acute subdural hematoma (SDH), respectively; and 12 (75.0%) vs. 4 (36.4%;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.045) in 27 young adults (\u226450 years) with acute SDH, respectively. There was a trend toward favorable outcomes for earlier time to reach 35.5\u00b0C (190 vs. 377\u2009min,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.052) and surgery (155 vs. 180\u2009min,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.096) in young patients with acute SDH. The second CT image revealed progression of the brain injury. This study demonstrated the potential benefits of early hypothermia in young patients with acute SDH, despite no difference in CT findings between the two groups. However, the small number of cases involved hindered the drawing of definitive conclusions. Future studies are warranted to validate the results.\n                  <\/jats:p>","DOI":"10.1089\/neur.2021.0080","type":"journal-article","created":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T10:42:56Z","timestamp":1657881776000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Benefits of Hypothermia for Young Patients with Acute Subdural Hematoma: A Computed Tomography Analysis of the Brain Hypothermia Study"],"prefix":"10.1177","volume":"3","author":[{"given":"Hitoshi","family":"Kobata","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Osaka Mishima Emergency Critical Care Center, Takatsuki, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Kuroda","sequence":"additional","affiliation":[{"name":"Department of Emergency, Disaster, and Critical Care Medicine, Kagawa University School of Medicine, Takamatsu, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiichi","family":"Suehiro","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, International University of Health and Welfare, School of Medicine, Narita, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Emergency and Critical Care Center, Mie University Hospital, Tsu, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoki","family":"Fujita","sequence":"additional","affiliation":[{"name":"Advanced Medical Emergency and Critical Care Center, Yamaguchi University Hospital, Ube, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naofumi","family":"Bunya","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine and Sapporo Medical University, Sapporo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Miyata","sequence":"additional","affiliation":[{"name":"Neurosurgery, Sapporo Medical University, Sapporo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine, Hyogo Emergency Medical Center, Kobe, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Hifumi","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine, St. Luke's International Hospital, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasutaka","family":"Oda","sequence":"additional","affiliation":[{"name":"Advanced Medical Emergency and Critical Care Center, Yamaguchi University Hospital, Ube, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Dohi","sequence":"additional","affiliation":[{"name":"Department of Emergency, Disaster and Critical Care Medicine, Showa University, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susumu","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Emergency and Critical Care Center, Tokuyama Central Hospital, Tokuyama, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Maekawa","sequence":"additional","affiliation":[{"name":"Yamaguchi Prefectural University, Yamaguchi, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the Brain Hypothermia (B-HYPO) Study Group in Japan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,7,15]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.1993.10.263"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199702203360803"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1993.79.3.0363"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200102223440803"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70300-8"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2013.3197"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1507581"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.17075"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2015.12.034"},{"key":"e_1_3_5_11_2","first-page":"2057","article-title":"A systematic review and meta-analysis of hypothermia in experimental traumatic brain injury: why have promising animal studies not been replicated in pragmatic clinical trials?","volume":"19","author":"Hirst T.C.","year":"2020","unstructured":"Hirst T.C., , Klasen M.G., , Rhodes J.K., , Macleod M.R., , and Andrews P.J.D. 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Neuroprotective effect of preoperatively induced mild hypothermia as determined by biomarkers and histopathological estimation in a rat subdural hematoma decompression model. J. Neurosurg, 118, 370\u201380.","journal-title":"J. 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