{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:46:19Z","timestamp":1777927579595,"version":"3.51.4"},"reference-count":74,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Neurotrauma Reports"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:p>\n                    This study examines the impact of lifetime blast exposure on white matter integrity in service members and veterans (SMVs). Participants were 227 SMVs, including those with a history of mild traumatic brain injury (mTBI;\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u2009124), orthopedic injury controls (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200958), and non-injured controls (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200945), prospectively enrolled in a Defense and Veterans Brain Injury Center (DVBIC)\/Traumatic Brain Injury Center of Excellence (TBICoE) study. Participants were divided into three groups based on number of self-reported lifetime blast exposures: none (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200953); low (i.e., 1\u20139 blasts;\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200981); and high (i.e., \u226510 blasts;\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200993). All participants underwent diffusion tensor imaging (DTI) at least 11 months post-injury. Tract-of-interest (TOI) analysis was applied to investigate fractional anisotropy and mean, radial, and axial diffusivity (AD) in left and right total cerebral white matter as well as 24 tracts. Benjamini-Hochberg false discovery rate (FDR) correction was used. Regressions investigating blast exposure and mTBI on white matter integrity, controlling for age, revealed that the presence of mTBI history was associated with lower AD in the bilateral superior longitudinal fasciculus and arcuate fasciculus and left cingulum (\u03b2s\u2009=\u2009\u22120.255 to \u22120.174;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    s\u2009&lt;\u20090.01); however, when non-injured controls were removed from the sample (but orthopedic injury controls remained), these relationships were attenuated and did not survive FDR correction. Regression models were rerun with modified post-traumatic stress disorder (PTSD) diagnosis added as a predictor. After FDR correction, PTSD was not significantly associated with white matter integrity in any of the models. Overall, there was no relationship between white matter integrity and self-reported lifetime blast exposure or PTSD.\n                  <\/jats:p>","DOI":"10.1089\/neur.2023.0043","type":"journal-article","created":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T10:44:28Z","timestamp":1702637068000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Lifetime Blast Exposure Is Not Related to White Matter Integrity in Service Members and Veterans With and Without Uncomplicated Mild Traumatic Brain Injury"],"prefix":"10.1177","volume":"4","author":[{"given":"Sara M.","family":"Lippa","sequence":"first","affiliation":[{"name":"Walter Reed National Military Medical Center, Bethesda, Maryland, USA."},{"name":"National Intrepid Center of Excellence, Bethesda, Maryland, USA."},{"name":"Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping-Hong","family":"Yeh","sequence":"additional","affiliation":[{"name":"Walter Reed National Military Medical Center, Bethesda, Maryland, USA."},{"name":"National Intrepid Center of Excellence, Bethesda, Maryland, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan E.","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Traumatic Brain Injury Center of Excellence, Silver Spring, Maryland, USA."},{"name":"Contractor, General Dynamics Information Technology, Silver Spring, Maryland, USA."},{"name":"Brooke Army Medical Center, Joint Base, San Antonio, Texas, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason M.","family":"Bailie","sequence":"additional","affiliation":[{"name":"Traumatic Brain Injury Center of Excellence, Silver Spring, Maryland, USA."},{"name":"Contractor, General Dynamics Information Technology, Silver Spring, Maryland, USA."},{"name":"33 Area Branch Clinic, Camp Pendleton, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Ollinger","sequence":"additional","affiliation":[{"name":"Walter Reed National Military Medical Center, Bethesda, Maryland, USA."},{"name":"National Intrepid Center of Excellence, Bethesda, Maryland, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tracey A.","family":"Brickell","sequence":"additional","affiliation":[{"name":"Walter Reed National Military Medical Center, Bethesda, Maryland, USA."},{"name":"National Intrepid Center of Excellence, Bethesda, Maryland, USA."},{"name":"Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA."},{"name":"Traumatic Brain Injury Center of Excellence, Silver Spring, Maryland, USA."},{"name":"Contractor, General Dynamics Information Technology, Silver Spring, Maryland, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis M.","family":"French","sequence":"additional","affiliation":[{"name":"Walter Reed National Military Medical Center, Bethesda, Maryland, USA."},{"name":"National Intrepid Center of Excellence, Bethesda, Maryland, USA."},{"name":"Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rael T.","family":"Lange","sequence":"additional","affiliation":[{"name":"Walter Reed National Military Medical Center, Bethesda, Maryland, USA."},{"name":"National Intrepid Center of Excellence, Bethesda, Maryland, USA."},{"name":"Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA."},{"name":"Traumatic Brain Injury Center of Excellence, Silver Spring, Maryland, USA."},{"name":"Contractor, General Dynamics Information Technology, Silver Spring, Maryland, USA."},{"name":"University of British Columbia, Vancouver, British Columbia, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,12,14]]},"reference":[{"issue":"4","key":"e_1_3_5_2_2","first-page":"S104","article-title":"Military traumatic brain and spinal column injury: a 5-year study of the impact blast and other military grade weaponry on the central nervous system","volume":"66","author":"Bell RS","year":"2009","unstructured":"Bell RS, , Vo AH, , Neal CJ, et al. 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