{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:46:21Z","timestamp":1777927581845,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Neurotrauma Reports"],"published-print":{"date-parts":[[2023,10,1]]},"abstract":"<jats:p>\n                    The majority of traumatic encephalopathy syndrome (TES) cases have been reported in former contact sport athletes. This is the first case with TES in a 19-year-old male patient with progressive cognitive decline after daily domestic physical violence through repeated hits to the head for 15 years. The patient presented with a moderate depressive episode and progressive cognitive decline. Tau positron emission tomography (PET) with 220\u2009MBq of [\n                    <jats:sup>18<\/jats:sup>\n                    F]PI-2620 revealed increased focal signal at the frontal and parietal white\/gray matter border. Brain magnetic resonance imaging (MRI) showed a cavum septum pellucidum, reduced left-sided hippocampal volume, and a left midbrain lesion. Cerebrospinal fluid results showed elevated total and p-tau. Neurocognitive testing at admission showed memory deficits clearly below average, and hampered dysfunctions according to the slow processing speed with a low mistake rate, indicating the acquired, thus secondary, attentional deficits. We diagnosed the patient with a TES suggestive of chronic traumatic encephalopathy and classified him as having subtle\/mild functional limitation with a most likely transition to mild dementia within the TES criteria. This report underlines child abuse as a relevant criterion in diagnosing TES in cases with repetitive hits to the head. In addition to clinical markers, we show the relevance of fluid tau biomarkers and tau-PET to support the diagnosis of TES according to the recently published diagnosis criteria for TES.\n                  <\/jats:p>","DOI":"10.1089\/neur.2023.0078","type":"journal-article","created":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T10:57:30Z","timestamp":1703674650000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Traumatic Encephalopathy Syndrome and Tauopathy in a 19-Year-Old With Child Abuse"],"prefix":"10.1177","volume":"4","author":[{"given":"Mike","family":"Rueb","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, LMU University Hospital, Munich, Germany."},{"name":"Pettenkofer School of Public Health, Munich, Germany."},{"name":"Institute for Medical Information Processing, Biometry and Epidemiology, LMU University Hospital, LMU Munich, Munich, Germany."},{"name":"Center for International Health (CIH LMU), LMU University Hospital, LMU Munich, Munich, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrin","family":"Rauen","sequence":"additional","affiliation":[{"name":"Department of Geriatric Psychiatry, Psychiatric Hospital Zurich, University of Zurich, Zurich, Switzerland."},{"name":"Institute for Stroke and Dementia Research (ISD), LMU University Hospital, LMU Munich, Munich, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inga Katharina","family":"Koerte","sequence":"additional","affiliation":[{"name":"Psychiatric Neuroimaging Laboratory, Brigham and Women's Hospital, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA."},{"name":"Department of Child and Adolescent Psychiatry, Psychosomatic, and Psychotherapy, LMU University Hospital, Munich, Germany."},{"name":"Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Gersing","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, LMU University Hospital, LMU Munich, Munich, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, M\u00f6lndal, Sweden."},{"name":"Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, M\u00f6lndal, Sweden."},{"name":"Department of Neurodegenerative Disease, Institute of Neurology, University College London, London, United Kingdom."},{"name":"UK Dementia Research Institute, University College London, London, United Kingdom."},{"name":"Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China."},{"name":"Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin\u2013Madison, Madison, Wisconsin, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel","family":"Simr\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, M\u00f6lndal, Sweden."},{"name":"Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, M\u00f6lndal, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"TES Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Brendel","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany."},{"name":"German Center for Neurodegenerative Diseases (DZNE) Munich, Germany."},{"name":"Munich Cluster for Systems Neurology (SyNergy), Munich, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Adorjan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, LMU University Hospital, Munich, Germany."},{"name":"Center for International Health (CIH LMU), LMU University Hospital, LMU Munich, Munich, Germany."},{"name":"Institute of Psychiatric Phenomics and Genomics, LMU University Hospital, Munich, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,12,26]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001349"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nec.2016.05.009"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000011850"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlab015"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-021-01189-4"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.2526"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2015.3880"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-018-9895-z"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2016.127"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1715095"}],"container-title":["Neurotrauma 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