{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T21:54:06Z","timestamp":1793224446602,"version":"4.5.0"},"reference-count":91,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Neurotrauma Reports"],"published-print":{"date-parts":[[2024,4,1]]},"abstract":"<jats:p>\n                    The central nervous system (CNS) evokes a complex inflammatory response to injury. Inflammatory cascades are present in traumatic, infectious, and noninfectious disorders affecting the brain. It contains a mixture of pro- and anti-inflammatory reactions involving well-known proteins, but also numerous proteins less explored in these processes. The aim of this study was to explore the distinct inflammatory response in traumatic brain injury (TBI) compared with other CNS injuries by utilization of mass-spectrometry. In total, 46 patients had their cerebrospinal fluid (CSF) analyzed with the use of mass-spectrometry. Among these, CSF was collected via an external ventricular drain (EVD) from\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 12 patients with acute TBI. The resulting protein findings were then compared with CSF obtained by lumbar puncture from\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 14 patients with noninfectious CNS disorders comprising relapsing\u2013remitting multiple sclerosis, anti-\n                    <jats:italic toggle=\"yes\">N<\/jats:italic>\n                    -methyl-\n                    <jats:sc>d<\/jats:sc>\n                    -aspartate-receptor encephalitis, acute disseminated encephalomyelitis, and\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 13 patients with progressive multifocal leukoencephalopathy, herpes simplex encephalitis, and other types of viral meningitis. We also utilized\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 7 healthy controls (HC). In the comparison between TBI and noninfectious inflammatory CNS disorders, concentrations of 57 proteins significantly differed between the groups. Among them, 20 and 37 proteins were up- and downregulated, respectively. No proteins were uniquely identified in the TBI group. In the comparison of TBI and HC, 55 proteins were significantly different, with 24 and 31 proteins being up- and downregulated, respectively. Four proteins were uniquely identified in the TBI group, (FGG, HBA1, TKT, CA1). In the TBI versus infectious inflammatory CNS disorders, 57 proteins differed significantly between the groups, with 17 and 40 proteins being up- and downregulated, respectively. No proteins were uniquely identified in the TBI group. Due to large discrepancies between the groups compared, the following proteins were selected for further deeper analysis among those being differentially regulated: APOE, CFB, CHGA, CHI3L1, C3, FCGBP, FGA, GSN, IGFBP7, SERPINA3, SOD3, and TTR. We found distinct proteomic profiles in the CSF of TBI patients compared with HC and different disease controls, indicating a specific interplay between inflammatory factors, metabolic response, and cell integrity. In relation to primarily infectious or inflammatory disorders, unique inflammatory pathways seem to be engaged, and could potentially serve as future treatment targets.\n                  <\/jats:p>","DOI":"10.1089\/neur.2024.0050","type":"journal-article","created":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T20:16:37Z","timestamp":1726863397000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Deciphering Proteomic Expression in Inflammatory Disorders: A Mass Spectrometry Exploration Comparing Infectious, Noninfectious, and Traumatic Brain Injuries in Human Cerebrospinal Fluid"],"prefix":"10.1177","volume":"5","author":[{"given":"Philip","family":"Dyhrfort","sequence":"first","affiliation":[{"name":"Department of Medical Sciences, Uppsala University, Uppsala, 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