{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:48:35Z","timestamp":1777927715896,"version":"3.51.4"},"reference-count":51,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Neurotrauma Reports"],"published-print":{"date-parts":[[2024,4,1]]},"abstract":"<jats:p>\n                    Surgical site infections (SSIs) remain a major cause of life-threatening morbidity following surgery for depressed skull fractures (DSFs) among patients with traumatic brain injury (TBI). The timing of the surgery for DSF has been questioned as a risk of SSI without a clear cutoff. We aimed to compare the risk of SSI within 3 months between surgery done before versus after 48 h of injury and with its preoperative predictors. We conducted a prospective cohort study at Mulago Hospital, Uganda. Patients with mild-to-moderate TBI with DSF were followed up perioperatively from the operating time up to 3 months. The outcome variables were the incidence risk of SSI, types of SSI, microbial culture patterns of wound isolates, and hospital length of stay. We enrolled 127 patients with DSF, median age = 24 (interquartile range [IQR] = 17\u201331 years), 88.2% (112\/127) male, and assault victims = 53.5%. The frontal bone involved 59%, while 50.4% had a dural tear. The incidence of SSI was 18.9%, mainly superficial incisional infection; Gram-negative microorganisms were the most common isolates (64.7%). The group of surgical intervention &gt;48 h had an increased incidence of SSI (57.3% vs. 42.7%,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = 0.006), a longer median of postoperative hospital stay (8[IQR = 6\u201312] days versus 5 [IQR = 4\u20139], [\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt; 0.001]), and a higher rate of reoperation (71.4% vs. 28.6%,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = 0.05) in comparison with the group of \u226448 h. In multivariate analysis between the group of SSI and no SSI, surgical timing &gt;48 h (95% confidence interval [CI], 1.25\u20136.22), pneumocranium on computed tomography [CT] scan (95% CI: 1.50\u20135.36), and involvement of air sinus (95% CI: 1.55\u20135.47) were associated with a &gt;2.5-fold increase in the rate of SSI. The SSI group had a longer median hospital stay (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    value &lt;0.001). The SSI risk in DSF is high following a surgical intervention &gt;48 h of injury, with predictors such as the frontal location of DSF, pneumocranium on a CT scan, and involvement of the air sinus. We recommend early surgical intervention within 48 h of injury.\n                  <\/jats:p>","DOI":"10.1089\/neur.2024.0088","type":"journal-article","created":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T20:11:28Z","timestamp":1726863088000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Timing of Surgery and Preoperative Predictors of Surgical Site Infections for Patients with Depressed Skull Fractures in a Sub-Saharan Tertiary Hospital: A Prospective Cohort Study"],"prefix":"10.1177","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1913-4378","authenticated-orcid":false,"given":"Herv\u00e9 Monka","family":"Lekuya","sequence":"first","affiliation":[{"name":"Department of Surgery\/Neurosurgery, College of Health Sciences, Makerere University, Kampala, Uganda."},{"name":"Department of Human Structure and Repair\/Neurosurgery UZ Gent, Ghent University, Ghent, Belgium."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jelle","family":"Vandersteene","sequence":"additional","affiliation":[{"name":"Department of Human Structure and Repair\/Neurosurgery UZ Gent, Ghent University, Ghent, Belgium."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larrey Kasereka","family":"Kamabu","sequence":"additional","affiliation":[{"name":"Department of Surgery\/Neurosurgery, College of Health Sciences, Makerere University, Kampala, Uganda."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rose","family":"Nantambi","sequence":"additional","affiliation":[{"name":"Department of Surgery\/Neurosurgery, College of Health Sciences, Makerere University, Kampala, Uganda."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald","family":"Mbiine","sequence":"additional","affiliation":[{"name":"Department of Surgery\/Neurosurgery, College of Health Sciences, Makerere University, Kampala, Uganda."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Kirabira","sequence":"additional","affiliation":[{"name":"School of Public Health, College of Health Sciences, Makerere University, Kampala, Uganda."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fredrick","family":"Makumbi","sequence":"additional","affiliation":[{"name":"School of Public Health, College of Health Sciences, Makerere University, Kampala, Uganda."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Cose","sequence":"additional","affiliation":[{"name":"Medical Research Council\/London School of Hygiene &amp; Tropical Medicine, MRC Uganda, Entebbe ,Uganda."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David Patrick","family":"Kateete","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, College of Health Sciences, Makerere University, Kampala, Uganda."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Kaddumukasa","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Health Sciences, Makerere University, Kampala, Uganda."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Baert","sequence":"additional","affiliation":[{"name":"Department of Human Structure and Repair\/Neurosurgery UZ Gent, Ghent University, Ghent, Belgium."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moses","family":"Galukande","sequence":"additional","affiliation":[{"name":"Department of Surgery\/Neurosurgery, College of Health Sciences, Makerere University, Kampala, Uganda."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Pierre Okito","family":"Kalala","sequence":"additional","affiliation":[{"name":"Department of Human Structure and Repair\/Neurosurgery UZ Gent, Ghent University, Ghent, Belgium."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,9,20]]},"reference":[{"key":"e_1_3_7_2_2","volume-title":"Head injury. 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