{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T12:33:25Z","timestamp":1791030805587,"version":"4.1.0"},"reference-count":0,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T00:00:00Z","timestamp":1101859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["OMICS: A Journal of Integrative Biology"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Streptococcus pneumoniae<\/jats:italic>\n                    open reading frame SP0082 encodes a surface protein that contains\nfour copies of a novel conserved repeat domain that bears no significant sequence similarity\nto proteins of known function. Homologous sequences from other streptococci contain\ntwo to six of these repeats, designated the SSURE (\n                    <jats:underline>s<\/jats:underline>\n                    treptococcal\n                    <jats:underline>su<\/jats:underline>\n                    rface\n                    <jats:underline>re<\/jats:underline>\n                    peat) domain.\nTo investigate the functional role(s) of this domain, the third SSURE repeat of SP0082 sequence\nhas been expressed in\n                    <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                    , purified to homogeneity and characterized\nby biochemical and immunological methods. The expressed protein fragment was found to\nbind to fibronectin, but not to collagen or submaxillary mucin. Anti-SSURE antibodies recognized\nthe corresponding protein on the surface of pneumococcal cells. These data identify\n                    <jats:italic toggle=\"yes\">S. pneumoniae<\/jats:italic>\n                    SP0082 protein and its homologs in other streptococci as fibronectin-binding\nsurface adhesins. The SSURE domain is likely to contain a novel protein fold, which was\ntentatively modeled using\n                    <jats:italic toggle=\"yes\">ab initio<\/jats:italic>\n                    modeling methods.\n                  <\/jats:p>","DOI":"10.1089\/omi.2004.8.341","type":"journal-article","created":{"date-parts":[[2005,2,9]],"date-time":"2005-02-09T14:58:23Z","timestamp":1107961103000},"page":"341-356","source":"Crossref","is-referenced-by-count":26,"title":["Sequence Analysis and Characterization of a Novel Fibronectin-Binding Repeat Domain from the Surface of\n                    <i>Streptococcus pneumoniae<\/i>"],"prefix":"10.1177","volume":"8","author":[{"given":"Daniela","family":"Bumbaca","sequence":"first","affiliation":[{"name":"Children's Hospital Oakland Research Institute, Oakland, California."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"LittleJohn","sequence":"additional","affiliation":[{"name":"Children's Hospital Oakland Research Institute, Oakland, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Nayakanti","sequence":"additional","affiliation":[{"name":"Children's Hospital Oakland Research Institute, Oakland, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Rigden","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, University of Liverpool, Liverpool, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Y.","family":"Galperin","sequence":"additional","affiliation":[{"name":"National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Jedrzejas","sequence":"additional","affiliation":[{"name":"Children's Hospital Oakland Research Institute, Oakland, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2004,12]]},"container-title":["OMICS: A Journal of Integrative Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/omi.2004.8.341","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/omi.2004.8.341","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:52:53Z","timestamp":1777675973000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/omi.2004.8.341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,12]]}},"alternative-id":["10.1089\/omi.2004.8.341"],"URL":"https:\/\/doi.org\/10.1089\/omi.2004.8.341","relation":{},"ISSN":["1536-2310","1557-8100"],"issn-type":[{"value":"1536-2310","type":"print"},{"value":"1557-8100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,12]]}}}