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However, the issues of specificity or redundancy of disease-associated salivary biomarkers have not been described. This systematic review was therefore aimed to define and summarize disease-related salivary biomarkers identified by mass spectrometry proteomics. Peer-reviewed articles published through July 2009 within three databases were reviewed. Out of 243 articles, 21 studies were selected in this systematic review with conditions including Sj\u00f6gren's syndrome, squamous cell carcinoma, dental caries, diabetes, breast cancer, periodontitis, gastric cancer, systemic sclerosis, oral lichen planus, bleeding oral cavity, and graft-versus-host disease. The sample size ranged from 3\u201341 in both diseased and control subjects, with no consensus on sample collection protocol. One hundred eighty biomarkers were identified in total; 87 upregulated, 63 downregulated, and 30 varying based on disease. Except for Sj\u00f6gren's syndrome, the majority of studies with the same disease produce inconsistent biomarkers. Larger sample size and standardization of sample collection\/treatment protocol may improve future studies.<\/jats:p>","DOI":"10.1089\/omi.2010.0134","type":"journal-article","created":{"date-parts":[[2011,5,13]],"date-time":"2011-05-13T19:05:59Z","timestamp":1305313559000},"page":"353-361","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":148,"title":["Defining Salivary Biomarkers Using Mass Spectrometry-Based Proteomics: A Systematic Review"],"prefix":"10.1177","volume":"15","author":[{"given":"Sandra K.","family":"Al-Tarawneh","sequence":"first","affiliation":[{"name":"University of North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B.","family":"Border","sequence":"additional","affiliation":[{"name":"University of North Carolina"},{"name":"University of Mount Union"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher F.","family":"Dibble","sequence":"additional","affiliation":[{"name":"University of North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sompop","family":"Bencharit","sequence":"additional","affiliation":[{"name":"University of North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,6]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874210600903010074"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2008.02041.x"},{"key":"e_1_3_3_4_1","first-page":"1820","article-title":"Association of psoriasin (S100A7) with clinical manifestations of systemic sclerosis: is its presence in whole saliva a potential predictor of pulmonary involvement?","volume":"35","author":"Baldini C.","year":"2008","unstructured":"Baldini C., , Giusti L., , Bazzichi L., , Ciregia F., , Giannaccini G., , Giacomelli C. et al. 2008a. 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