{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:52:46Z","timestamp":1777927966879,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["OMICS: A Journal of Integrative Biology"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This article analyzes and theorizes the current knowledge silos at the intersection of omics science, ophthalmology, personalized medicine, and global visual health. Visual disorders represent one of the largest health care expenditures in the United States, costing $139 billion per year. In middle-income and industrialized countries, glaucoma is a World Health Organization priority category eye disease, known for difficulties in its early diagnosis, chronic progressive nature, and large person-to-person differences in drug efficacy and safety. A complex disease, glaucoma is best conceptualized as a syndrome displaying an ostensibly common clinical end-point, but with vastly heterogeneous molecular underpinnings and host\u2013environment interactions. About 12% of all global blindness is attributable to glaucoma.\n                    <jats:italic toggle=\"yes\">Glaucomics<\/jats:italic>\n                    is a term that we coin here so as to introduce omics science and systems diagnostics to ophthalmology, a field that can benefit enormously from personalized medicine, and which has sadly lagged behind in systems diagnostics compared to fields such as oncology. We define glaucomics as the integrated use of multi-omics and systems science approaches towards rational discovery, development, and tandem applications of diagnostics and therapeutics, for glaucoma specifically, and for personalized visual health, more broadly. We propose that glaucoma is one of the neglected lowest hanging fruits and actionable targets for omics and systems diagnostics in 21\n                    <jats:sup>st<\/jats:sup>\n                    century ophthalmology for the salient reasons we describe here. Additionally, we offer an analysis on two of the most pertinent neglected tropical diseases (NTDs), trachoma and river blindness, which continue to plague visual health in developing countries. We conclude with a call for research on omics applications in glaucoma and personalized visual health.\n                  <\/jats:p>","DOI":"10.1089\/omi.2014.0040","type":"journal-article","created":{"date-parts":[[2014,4,14]],"date-time":"2014-04-14T09:19:17Z","timestamp":1397467157000},"page":"275-279","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Glaucomics: A Call for Systems Diagnostics for 21\n                    <sup>st<\/sup>\n                    Century Ophthalmology and Personalized Visual Health"],"prefix":"10.1177","volume":"18","author":[{"given":"K\u0131van\u00e7","family":"G\u00fcng\u00f6r","sequence":"first","affiliation":[{"name":"Gaziantep University","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.","family":"Hotez","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine"},{"name":"Sabin Vaccine Institute and Texas Children's Hospital Center for Vaccine Development"},{"name":"Rice University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vural","family":"\u00d6zdemir","sequence":"additional","affiliation":[{"name":"Gaziantep University","place":["Turkey"]},{"name":"Gaziantep University","place":["Turkey"]},{"name":"Gaziantep University","place":["Turkey"]},{"name":"Amrita University","place":["India"]},{"name":"Data-Enabled Life Sciences Alliance (DELSA Global)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u015e\u00fckr\u00fc","family":"Aynac\u0131o\u011flu","sequence":"additional","affiliation":[{"name":"Gaziantep University","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,5]]},"reference":[{"key":"e_1_3_3_2_1","unstructured":"Agency for Healthcare Research and Quality (AHRQ) (2010). 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