{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:54:54Z","timestamp":1777928094972,"version":"3.51.4"},"reference-count":62,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["OMICS: A Journal of Integrative Biology"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    HIV infection remains a major global health burden since its discovery in 1983. Sub-Saharan Africa is the region hardest hit by the HIV\/AIDS pandemic where 63% of the 33 million infected people live. While there is marked person-to-person variability in susceptibility, progression, and survival with HIV infection, there is a paucity of predictive diagnostics associated with these clinical endpoints. In this regard, the deficiency in plasma Mannose Binding Lectin (MBL) is a common opsonic defect reported to increase susceptibility infections, including HIV. To the best of our knowledge, we report here the first study on the putative role of MBL deficiency on HIV progression and survival in an African adult population. We hypothesized that MBL deficiency has a role to play in HIV infection by increasing HIV disease progression and decreasing survival. We assessed the role of MBL deficiency on HIV disease progression and survival in a Zimbabwean adult population enrolled in the Mupfure Schistosomiasis and HIV (MUSH) cohort. We analyzed blood samples for MBL levels,\n                    <jats:italic toggle=\"yes\">MBL2<\/jats:italic>\n                    genotypes, HIV-1 status, viral load, and CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cell counts. Participants were followed for 3 years wherein the endpoints were measured at baseline, 6 weeks, and 3, 6, 12, 24, and 36 months. Disease progression was measured as the rate of decline in CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cell counts and the rate of increase in HIV viral load. We assessed 197 HIV positive adults where 83% (164) were women with a median age of 31 years. Prevalence of plasma MBL deficiency (less than 100\u2009\u03bcg\/L) and\n                    <jats:italic toggle=\"yes\">MBL2<\/jats:italic>\n                    deficient genetic variants (\n                    <jats:italic toggle=\"yes\">A\/O<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">O\/O<\/jats:italic>\n                    genotypes) was 21% (42 out of 197) and 39% (74 out of 190), respectively. We did not observe a significant role to explain individual variation in mortality, change of CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cell count, and viral load by MBL plasma deficiency or\n                    <jats:italic toggle=\"yes\">MBL2<\/jats:italic>\n                    genetic variants from baseline to 3 years follow up period in this adult population. We suggest the need for global OMICS research and that the present findings attest to the large between-population variability in a host of factors that can predispose individuals susceptible to HIV progression and mortality. We therefore cannot recommend at this time the use of plasma MBL levels or\n                    <jats:italic toggle=\"yes\">MBL2<\/jats:italic>\n                    genetic variants as a prognostic marker in HIV infection, disease progression, and survival in this adult population in Africa.\n                  <\/jats:p>","DOI":"10.1089\/omi.2015.0047","type":"journal-article","created":{"date-parts":[[2015,9,8]],"date-time":"2015-09-08T14:32:21Z","timestamp":1441722741000},"page":"542-552","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["HIV-1 Disease Progression and Survival in an Adult Population in Zimbabwe: Is There an Effect of the Mannose Binding Lectin Deficiency?"],"prefix":"10.1177","volume":"19","author":[{"given":"Rutendo B.L","family":"Zinyama-Gutsire","sequence":"first","affiliation":[{"name":"University of the Witwatersrand","place":["South Africa"]},{"name":"Medical Research Council of Zimbabwe","place":["Zimbabwe"]},{"name":"Letten Research Foundation","place":["Zimbabwe"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Chasela","sequence":"additional","affiliation":[{"name":"University of the Witwatersrand","place":["South Africa"]},{"name":"Human Sciences Research Council","place":["South Africa"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per","family":"Kallestrup","sequence":"additional","affiliation":[{"name":"Aarhus University","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simbarashe","family":"Rusakaniko","sequence":"additional","affiliation":[{"name":"Letten Research Foundation","place":["Zimbabwe"]},{"name":"University of Zimbabwe, College of Health Sciences, Harare, Zimbabwe."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Christiansen","sequence":"additional","affiliation":[{"name":"Statens Serum Institute","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Ngara","sequence":"additional","affiliation":[{"name":"Letten Research Foundation","place":["Zimbabwe"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Exnevia","family":"Gomo","sequence":"additional","affiliation":[{"name":"University of Zimbabwe, Harare","place":["Zimbabwe"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Ullum","sequence":"additional","affiliation":[{"name":"Copenhagen University","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Erikstrup","sequence":"additional","affiliation":[{"name":"Copenhagen University","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans O.","family":"Madsen","sequence":"additional","affiliation":[{"name":"Copenhagen University","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Babill","family":"Stray-Pedersen","sequence":"additional","affiliation":[{"name":"Letten Research Foundation","place":["Zimbabwe"]},{"name":"University of Zimbabwe, College of Health Sciences, Harare, Zimbabwe."},{"name":"Rigshospitalet Oslo University Hospital and University of Oslo","place":["Norway"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Garred","sequence":"additional","affiliation":[{"name":"Copenhagen University","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takafira","family":"Mduluza","sequence":"additional","affiliation":[{"name":"University of Zimbabwe, Biochemistry Department, Harare, Zimbabwe and Department of Laboratory Medicine and Medical Sciences, University of KwaZulu Natal, Durban, South Africa."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,9]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2014.0080"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit081"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6363685"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2014.0063"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199501263320401"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1086\/588712"},{"key":"e_1_3_3_8_1","first-page":"1","article-title":"1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults","volume":"41","author":"CDC","year":"1993","unstructured":"CDC. 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