{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T12:08:56Z","timestamp":1779192536510,"version":"3.51.4"},"reference-count":127,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["OMICS: A Journal of Integrative Biology"],"published-print":{"date-parts":[[2016,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Sickle cell disease (SCD) is a blood disease caused by a single nucleotide substitution (T &gt; A) in the beta globin gene on chromosome 11. The single point mutation (Glu6Val) promotes polymerization of hemoglobin S (HbS) and causes sickling of erythrocytes. Vaso-occlusive painful crises are associated with recurrent and long-term use of analgesics\/opioids and hydroxyurea (HU) by people living with SCD. The present analysis offers a state-of-the-art expert review of the effectiveness of pharmacogenomics\/genetics of pain management in SCD, with specific focus on HU and opioids. The literature search used the following keywords: SCD, pharmacogenomics, pharmacogenetics, pain, antalgics, opioids, morphine, and HU. The literature was scanned until March 2016, with specific inclusion of targeted landmark and background articles on SCD. Surprisingly, our review identified only a limited number of studies that addressed the genetic\/genomic basis of variable responses to pain (e.g., variants in\n                    <jats:italic toggle=\"yes\">OPRM1<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">HMOX-1<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">GCH1<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">VEGFA COMT<\/jats:italic>\n                    genes), and pharmacogenomics of antalgics and opioids (e.g., variants in\n                    <jats:italic toggle=\"yes\">OPRM1<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">STAT6<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">ABCB1<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">COMT<\/jats:italic>\n                    genes) in SCD. There has been greater progress made toward identifying the key genomic variants, mainly in\n                    <jats:italic toggle=\"yes\">BCL11A<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">HBS1L-MYB<\/jats:italic>\n                    , or\n                    <jats:italic toggle=\"yes\">SAR1<\/jats:italic>\n                    , which contribute to response to HU treatment. However, the complete picture on pharmacogenomic determinants of the above therapeutic phenotypes remains elusive. Strikingly, no study has been conducted in sub-Saharan Africa where majority of the patients with SCD live. This alerts the broader global life sciences community toward the existing disparities in optimal and ethical targeting of research and innovation investments for SCD specifically and precision medicine and pharmacology research broadly.\n                  <\/jats:p>","DOI":"10.1089\/omi.2016.0105","type":"journal-article","created":{"date-parts":[[2016,9,16]],"date-time":"2016-09-16T15:20:12Z","timestamp":1474039212000},"page":"565-574","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["An Expert Review of Pharmacogenomics of Sickle Cell Disease Therapeutics: Not Yet Ready for Global Precision Medicine"],"prefix":"10.1177","volume":"20","author":[{"given":"Khuthala","family":"Mnika","sequence":"first","affiliation":[{"name":"University of Cape Town"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gift D.","family":"Pule","sequence":"additional","affiliation":[{"name":"University of Cape Town"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Collet","family":"Dandara","sequence":"additional","affiliation":[{"name":"University of Cape Town"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ambroise","family":"Wonkam","sequence":"additional","affiliation":[{"name":"University of Cape Town"},{"name":"University of Cape Town"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,10,1]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1099800409337154"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/03630269.2011.617230"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-003-0836-5"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12003"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24100"},{"key":"e_1_3_3_7_1","volume-title":"Sickle Cell Pain","author":"Ballas SK","year":"2015","unstructured":"Ballas SK. (2015). Sickle Cell Pain. Lippincott: Williams and Wilkins."},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20336"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-04-383430"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e328351c35f"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12507"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23613"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/09638280400009030"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2004.02340.x"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.7.1723"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5449.2495"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.16.9608"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.2217\/pgs.12.125"},{"key":"e_1_3_3_19_1","first-page":"195","article-title":"Seroprevalence of parvovirus B19 and its clinical effect among anaemic SCA patients in Northeastern Nigeria","volume":"4","author":"Bukar AA","year":"2013","unstructured":"Bukar AA, , Abjah UAM, , Kagu MB, et al. (2013). Seroprevalence of parvovirus B19 and its clinical effect among anaemic SCA patients in Northeastern Nigeria. Am J Sci Ind Res, 4, 195\u2013200.","journal-title":"Am J Sci Ind Res"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2007.01.049"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature15521"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V79.10.2555.2555"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199505183322001"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24235"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200608000-00016"},{"key":"e_1_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-8-169"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.20057"},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12791"},{"key":"e_1_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21027"},{"key":"e_1_3_3_30_1","first-page":"125","article-title":"Long-term hydroxyurea treatment in children with sickle cell disease: Tolerance and clinical outcomes","volume":"91","author":"de Montalembert M","year":"2006","unstructured":"de Montalembert M, , Brousse V, , Elie C, et al. (2006). Long-term hydroxyurea treatment in children with sickle cell disease: Tolerance and clinical outcomes. Haematologica, 91, 125\u2013128.","journal-title":"Haematologica"},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.1586\/17474086.2014.959922"},{"key":"e_1_3_3_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-200209000-00010"},{"key":"e_1_3_3_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi013"},{"key":"e_1_3_3_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-005-1026-4"},{"key":"e_1_3_3_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2003.10.006"},{"key":"e_1_3_3_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.revmed.2015.10.352"},{"key":"e_1_3_3_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(68)90266-0"},{"key":"e_1_3_3_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2007.09.005"},{"key":"e_1_3_3_39_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-01-478776"},{"key":"e_1_3_3_40_1","first-page":"43","article-title":"Sickle cell disease: Time for a targeted neonatal screening programme","volume":"8","author":"Gibbons C","year":"2015","unstructured":"Gibbons C, , Geoghegan R, , Conroy H, et al. (2015). Sickle cell disease: Time for a targeted neonatal screening programme. Ir Med J, 8, 43\u201345.","journal-title":"Ir Med J"},{"key":"e_1_3_3_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2011.09.013"},{"key":"e_1_3_3_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24557"},{"key":"e_1_3_3_43_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-12-4973"},{"key":"e_1_3_3_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2008.02.003"},{"key":"e_1_3_3_45_1","first-page":"179","article-title":"Peculiar elongated and sickle-shaped red blood corpuscles in a case of severe anemia","volume":"74","author":"Herrick JB","year":"2000","unstructured":"Herrick JB. (2000). Peculiar elongated and sickle-shaped red blood corpuscles in a case of severe anemia. Yale J Biol Med, 74, 179\u2013184.","journal-title":"Yale J Biol Med"},{"key":"e_1_3_3_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-200201000-00001"},{"key":"e_1_3_3_47_1","doi-asserted-by":"publisher","DOI":"10.2217\/pgs.15.126"},{"key":"e_1_3_3_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23137"},{"key":"e_1_3_3_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2013.09.001"},{"key":"e_1_3_3_50_1","first-page":"1550","article-title":"Safety of hydroxyurea in children with sickle cell anemia: Results of the HUG-KIDS study, a phase I\/II trial. Pediatric Hydroxyurea Group","volume":"94","author":"Kinney TR","year":"1999","unstructured":"Kinney TR, , Helms RW, , O'Branski EE, et al. (1999). Safety of hydroxyurea in children with sickle cell anemia: Results of the HUG-KIDS study, a phase I\/II trial. Pediatric Hydroxyurea Group. Blood, 94, 1550\u20131554.","journal-title":"Blood"},{"key":"e_1_3_3_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2004.00517.x"},{"key":"e_1_3_3_52_1","doi-asserted-by":"publisher","DOI":"10.3109\/08039488909100832"},{"key":"e_1_3_3_53_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M107543200"},{"key":"e_1_3_3_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07045.x"},{"key":"e_1_3_3_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-015-2573-y"},{"key":"e_1_3_3_56_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0804799105"},{"key":"e_1_3_3_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(97)00353-7"},{"key":"e_1_3_3_58_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-200201000-00002"},{"key":"e_1_3_3_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.01.010"},{"key":"e_1_3_3_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.tpj.6500433"},{"key":"e_1_3_3_61_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-08-302703"},{"key":"e_1_3_3_62_1","first-page":"2013","article-title":"Sickle cell disease: New opportunities and challenges in Africa","author":"Makani J","year":"2013","unstructured":"Makani J, , Ofori-Acquah SF, , Nnodu O, , Wonkam A, , and Ohene-Frempong K. (2013). Sickle cell disease: New opportunities and challenges in Africa. Sci World J. 2013.","journal-title":"Sci World J"},{"key":"e_1_3_3_63_1","doi-asserted-by":"publisher","DOI":"10.6000\/1929-4247.2012.01.01.10"},{"key":"e_1_3_3_64_1","first-page":"43","article-title":"Morphine 6beta glucuronide: Fortuitous morphine metabolite or preferred peripheral regulatory opiate?","volume":"11","author":"Mantione KJ","year":"2005","unstructured":"Mantione KJ, , Goumon Y, , Esch T, , and Stefano GB. (2005). Morphine 6beta glucuronide: Fortuitous morphine metabolite or preferred peripheral regulatory opiate?. Med Sci Monitr, 11, 43\u201346.","journal-title":"Med Sci Monitr"},{"key":"e_1_3_3_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/383819a0"},{"key":"e_1_3_3_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23578"},{"key":"e_1_3_3_67_1","first-page":"592","article-title":"Pharmacokinetic modelling of morphine, morphine-3-glucuronide and morphine-6-glucuronide in plasma and cerebrospinal fluid of neurosurgical patients after short-term infusion of morphine","volume":"54","author":"Meineke I","year":"2002","unstructured":"Meineke I, , Freudenthaler S, , Hofmann U, et al. (2002). Pharmacokinetic modelling of morphine, morphine-3-glucuronide and morphine-6-glucuronide in plasma and cerebrospinal fluid of neurosurgical patients after short-term infusion of morphine. Br J Clin Pharmacol, 54, 592\u2013603.","journal-title":"Br J Clin Pharmacol"},{"key":"e_1_3_3_68_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0125929"},{"key":"e_1_3_3_69_1","first-page":"480","article-title":"Global epidemiology of haemoglobin disorders and derived service indicators","volume":"86","author":"Modell B","year":"2008","unstructured":"Modell B, , and Darlison M. (2008). Global epidemiology of haemoglobin disorders and derived service indicators. Bull WHO, 86, 480\u2013487.","journal-title":"Bull WHO"},{"key":"e_1_3_3_70_1","first-page":"123","article-title":"Complex trait genetics of pain in the laboratory mouse","volume":"28","author":"Mogil JS","year":"2004","unstructured":"Mogil JS. (2004). Complex trait genetics of pain in the laboratory mouse. Pain Res Manag, 28, 123\u2013150.","journal-title":"Pain Res Manag"},{"key":"e_1_3_3_71_1","first-page":"1","article-title":"Introduction to pain genetics","volume":"28","author":"Mogil JS","year":"2004","unstructured":"Mogil JS, , and Devor M. (2004). Introduction to pain genetics. Pain Res Manag, 28, 1\u201320.","journal-title":"Pain Res Manag"},{"key":"e_1_3_3_72_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0111464"},{"key":"e_1_3_3_73_1","doi-asserted-by":"publisher","DOI":"10.1177\/00912700222011508"},{"key":"e_1_3_3_74_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198504043121403"},{"key":"e_1_3_3_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12190"},{"key":"e_1_3_3_76_1","first-page":"284","article-title":"Types of crises in sickle cell disease patients presenting at the haematology day care unit (HDCU), University College Hospital (UCH), Ibadan","volume":"25","author":"Olabode JO","year":"2006","unstructured":"Olabode JO, , and Shokunbi WA. (2006). Types of crises in sickle cell disease patients presenting at the haematology day care unit (HDCU), University College Hospital (UCH), Ibadan. West Afr J Med, 25, 284\u2013288.","journal-title":"West Afr J Med"},{"key":"e_1_3_3_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13001"},{"key":"e_1_3_3_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1990.2"},{"key":"e_1_3_3_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61229-X"},{"key":"e_1_3_3_80_1","doi-asserted-by":"publisher","DOI":"10.1093\/pubmed\/fdu026"},{"key":"e_1_3_3_81_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111464"},{"key":"e_1_3_3_82_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199107043250103"},{"key":"e_1_3_3_83_1","doi-asserted-by":"publisher","DOI":"10.1586\/17474086.2015.1078235"},{"key":"e_1_3_3_84_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-05-1453"},{"key":"e_1_3_3_85_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2008.059113"},{"key":"e_1_3_3_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2005.03.032"},{"key":"e_1_3_3_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61029-X"},{"key":"e_1_3_3_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.tpj.6500327"},{"key":"e_1_3_3_89_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0100516"},{"key":"e_1_3_3_90_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23457"},{"key":"e_1_3_3_91_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2011.1.273"},{"key":"e_1_3_3_92_1","doi-asserted-by":"publisher","DOI":"10.2350\/14-03-1452-OA.1"},{"key":"e_1_3_3_93_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910708601119"},{"key":"e_1_3_3_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(90)90619-3"},{"key":"e_1_3_3_95_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-08-239517"},{"key":"e_1_3_3_96_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0b013e3282ef6b2c"},{"key":"e_1_3_3_97_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.13.1645"},{"key":"e_1_3_3_98_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.3.1078"},{"key":"e_1_3_3_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21699"},{"key":"e_1_3_3_100_1","doi-asserted-by":"publisher","DOI":"10.1159\/000433518"},{"key":"e_1_3_3_101_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07650.x"},{"key":"e_1_3_3_102_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21738"},{"key":"e_1_3_3_103_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-720X.2005.tb00542.x"},{"key":"e_1_3_3_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2006.05.004"},{"key":"e_1_3_3_105_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2008.058958"},{"key":"e_1_3_3_106_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25875"},{"key":"e_1_3_3_107_1","first-page":"220","article-title":"Comprehensive care in sickle cell disease: Its impact on morbidity and mortality","volume":"28","author":"Vichinsky EP","year":"1991","unstructured":"Vichinsky EP. (1991). Comprehensive care in sickle cell disease: Its impact on morbidity and mortality. Sem Hematol, 28, 220\u2013226.","journal-title":"Sem Hematol"},{"key":"e_1_3_3_108_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-05-221333"},{"key":"e_1_3_3_109_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002120"},{"key":"e_1_3_3_110_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-07-364190"},{"key":"e_1_3_3_111_1","volume-title":"The Thalassaemia Syndromes","author":"Weatherall DJ","year":"2008","unstructured":"Weatherall DJ, , and Clegg JB. (2008). The Thalassaemia Syndromes, 4th ed. John Wiley & Sons, New Jersey, USA.","edition":"4"},{"key":"e_1_3_3_112_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-06-2404"},{"key":"e_1_3_3_113_1","first-page":"125","article-title":"Inheritance of low erythrocyte catechol-o-methyltransferase activity in man","volume":"29","author":"Weinshilboum RM","year":"1977","unstructured":"Weinshilboum RM, , and Raymond FA. (1977). Inheritance of low erythrocyte catechol-o-methyltransferase activity in man. Am J Hum Genet, 29, 125\u2013135.","journal-title":"Am J Hum Genet"},{"key":"e_1_3_3_114_1","doi-asserted-by":"publisher","DOI":"10.1086\/430744"},{"key":"e_1_3_3_115_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0092506"},{"key":"e_1_3_3_116_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897-014-9701-z"},{"key":"e_1_3_3_117_1","doi-asserted-by":"publisher","DOI":"10.7196\/SAMJ.5886"},{"key":"e_1_3_3_118_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23711"},{"key":"e_1_3_3_119_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1211053"},{"key":"e_1_3_3_120_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1897310"},{"key":"e_1_3_3_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2008.09.052"},{"key":"e_1_3_3_122_1","first-page":"1172","article-title":"Response to hydroxyurea treatment in Iranian transfusion-dependent beta-thalassemia patients","volume":"89","author":"Yavarian M","year":"2004","unstructured":"Yavarian M, , Karimi M, , Bakker E, , Harteveld CL, , and Giordano PC. (2004). Response to hydroxyurea treatment in Iranian transfusion-dependent beta-thalassemia patients. Haematologica, 89, 1172\u20131178.","journal-title":"Haematologica"},{"key":"e_1_3_3_123_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(200002)63:2<79::AID-AJH4>3.0.CO;2-D"},{"key":"e_1_3_3_124_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-10-534842"},{"key":"e_1_3_3_125_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-11-057893"},{"key":"e_1_3_3_126_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-07-2475"},{"key":"e_1_3_3_127_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1078546"},{"key":"e_1_3_3_128_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00108-016-0030-1"}],"container-title":["OMICS: A Journal of Integrative Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/omi.2016.0105","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/omi.2016.0105","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/omi.2016.0105","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T11:45:29Z","timestamp":1779191129000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/omi.2016.0105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,1]]},"references-count":127,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10,1]]}},"alternative-id":["10.1089\/omi.2016.0105"],"URL":"https:\/\/doi.org\/10.1089\/omi.2016.0105","relation":{},"ISSN":["1536-2310","1557-8100"],"issn-type":[{"value":"1536-2310","type":"print"},{"value":"1557-8100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,1]]}}}