{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T21:15:09Z","timestamp":1781298909480,"version":"3.54.1"},"reference-count":59,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["OMICS: A Journal of Integrative Biology"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The female\n                    <jats:italic toggle=\"yes\">Aedes aegypti<\/jats:italic>\n                    mosquito is an important vector for several tropical and subtropical diseases such as dengue, chikungunya, and Zika and yellow fever. The disease viruses infect the mosquito and subsequently spread to the salivary glands after which the viruses can be transmitted to humans with probing or feeding by the mosquito. Omics systems sciences offer the opportunity to characterize vectors and can inform disease surveillance, vector control and development of innovative diagnostics, personalized medicines, vaccines, and insecticide targets. Using high-resolution mass spectrometry, we performed an analysis of the\n                    <jats:italic toggle=\"yes\">A. aegypti<\/jats:italic>\n                    salivary gland proteome. The\n                    <jats:italic toggle=\"yes\">A. aegypti<\/jats:italic>\n                    proteome resulted in acquisition of 83,836 spectra. Upon searches against the protein database of the\n                    <jats:italic toggle=\"yes\">A. aegypti<\/jats:italic>\n                    , these spectra were assigned to 5417 unique peptides, belonging to 1208 proteins. To the best of our knowledge, this is the largest set of proteins identified in the\n                    <jats:italic toggle=\"yes\">A. aegypti<\/jats:italic>\n                    salivary gland. Of note, 29 proteins were involved in immunity-related pathways in salivary glands. A subset of these proteins is known to interact with disease viruses. Another 15 proteins with signal cleavage site were found to be secretory in nature, and thus possibly playing critical roles in blood meal ingestion. These findings provide a baseline to advance our understanding of vector-borne diseases and vector\u2013pathogen interactions before virus transmission in global health, and might therefore enable future design and development of virus-blocking strategies and novel molecular targets in the mosquito vector\n                    <jats:italic toggle=\"yes\">A. aegypti.<\/jats:italic>\n                  <\/jats:p>","DOI":"10.1089\/omi.2016.0160","type":"journal-article","created":{"date-parts":[[2017,1,12]],"date-time":"2017-01-12T11:26:38Z","timestamp":1484220398000},"page":"45-54","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":32,"title":["Mosquito-Borne Diseases and Omics: Salivary Gland Proteome of the Female\n                    <i>Aedes aegypti<\/i>\n                    Mosquito"],"prefix":"10.1177","volume":"21","author":[{"given":"Rakhi","family":"Dhawan","sequence":"first","affiliation":[{"name":"Armed Forces Medical College","place":["India"]},{"name":"National Institute of Malaria Research","place":["India"]},{"name":"Goa University","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish","family":"Kumar","sequence":"additional","affiliation":[{"name":"Institute of Bioinformatics","place":["India"]},{"name":"Manipal University","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajeet Kumar","family":"Mohanty","sequence":"additional","affiliation":[{"name":"National Institute of Malaria Research","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gourav","family":"Dey","sequence":"additional","affiliation":[{"name":"Institute of Bioinformatics","place":["India"]},{"name":"Manipal University","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayshree","family":"Advani","sequence":"additional","affiliation":[{"name":"Institute of Bioinformatics","place":["India"]},{"name":"Manipal University","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.S. 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