{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:50:24Z","timestamp":1790520624079,"version":"4.1.0"},"reference-count":60,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["OMICS: A Journal of Integrative Biology"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Coronary artery disease (CAD) is a significant contributor to global health burden.\n                    <jats:italic toggle=\"yes\">Adiponectin<\/jats:italic>\n                    gene single nucleotide polymorphisms (SNPs) have been associated with CAD susceptibility, but with inconsistent results across the studies. We present, in this study, an updated meta-analysis to discern the genetic susceptibility of\n                    <jats:italic toggle=\"yes\">adiponectin<\/jats:italic>\n                    SNPs in relation to CAD. PubMed and EMBASE databases were used to identify the relevant published articles using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Pooled odds ratios and 95% confidence intervals were generated to assess the strength of the associations. Thirty-five articles with a total of 28,947 participants (mean age 55.3 years, 11,632 cases\/17,315 controls, 19,443 males\/8353 females, and 1151 persons with unspecified gender data) were included. The dominant, recessive, and additive models were applied. We found that the SNPs\n                    <jats:italic toggle=\"yes\">+45T&gt;G<\/jats:italic>\n                    (\n                    <jats:italic toggle=\"yes\">rs2241766<\/jats:italic>\n                    ),\n                    <jats:italic toggle=\"yes\">\u22124034A&gt;C<\/jats:italic>\n                    (\n                    <jats:italic toggle=\"yes\">rs822395<\/jats:italic>\n                    ), and\n                    <jats:italic toggle=\"yes\">\u221211391G&gt;A<\/jats:italic>\n                    (\n                    <jats:italic toggle=\"yes\">rs17300539<\/jats:italic>\n                    ) were linked to CAD development. In addition,\n                    <jats:italic toggle=\"yes\">+276G&gt;T<\/jats:italic>\n                    (\n                    <jats:italic toggle=\"yes\">rs1501299<\/jats:italic>\n                    ) SNP was associated with a decreased susceptibility to CAD among Caucasians. We did not find an association between the CAD susceptibility and the\n                    <jats:italic toggle=\"yes\">\u221211377C&gt;G<\/jats:italic>\n                    (\n                    <jats:italic toggle=\"yes\">rs266729<\/jats:italic>\n                    ) SNP. These observations offer new potential genetic biomarker candidates in relation to CAD, and warrant further research in independent world populations.\n                  <\/jats:p>","DOI":"10.1089\/omi.2017.0007","type":"journal-article","created":{"date-parts":[[2017,6,15]],"date-time":"2017-06-15T16:33:26Z","timestamp":1497544406000},"page":"340-351","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["An Updated Systematic Review and Meta-analysis of Association Between\n                    <i>Adiponectin<\/i>\n                    Gene Polymorphisms and Coronary Artery Disease"],"prefix":"10.1177","volume":"21","author":[{"given":"Haifeng","family":"Hou","sequence":"first","affiliation":[{"name":"Taishan Medical University","place":["P.R. 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