{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:55:41Z","timestamp":1777928141060,"version":"3.51.4"},"reference-count":53,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["OMICS: A Journal of Integrative Biology"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Hearing impairment (HI) is one of the most disabling conditions of major global health burden that contributes adversely to the social and economic development of a country, if not managed properly. A proper assessment of the nationwide burden and etiology of HI is instrumental in the prevention, treatment, and management of the condition. This article sought to perform an expert review of HI in Ghana to determine the present knowledge of its burden and possible causes of the condition. A literature search was conducted in PubMed using the following keywords: \u201chearing loss\u201d OR \u201chearing impairment\u201d OR \u201cdeafness\u201d AND \u201cGhana.\u201d The literature was scanned until July 20, 2017, with specific inclusion of targeted landmark and background articles on HI. From the search, 18 of out 5869 articles were selected and considered for the review. The results of the search indicated that there were no extensive studies to determine the national burden of HI in Ghana. However, the few studies assessed suggested that the disease is either acquired or inherited. The burden of acquired HI was higher in adults than children, women than men, and people working in a noisy environment. Regarding the genetic cause, specific founder mutations in\n                    <jats:italic toggle=\"yes\">GJB2<\/jats:italic>\n                    gene (R143W, L79P, V178A, R184Q, A197S, I203K, and L214P) was the only identified genetic cause of HI in Ghana, but the other HI genes were not investigated. There has been some modest effort to study HI in Ghana, but comprehensive studies on the genetic and environmental etiologies (using the \u201cmulti-OMICS\u201d approaches), classification, and burden of HI on Ghana are needed.\n                  <\/jats:p>","DOI":"10.1089\/omi.2017.0145","type":"journal-article","created":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T16:42:47Z","timestamp":1510764167000},"page":"638-646","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Public Health Burden of Hearing Impairment and the Promise of Genomics and Environmental Research: A Case Study in Ghana, Africa"],"prefix":"10.1177","volume":"21","author":[{"given":"Samuel Mawuli","family":"Adadey","sequence":"first","affiliation":[{"name":"University of Ghana","place":["Ghana"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordon","family":"Awandare","sequence":"additional","affiliation":[{"name":"University of Ghana","place":["Ghana"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Goffrey Kwabla","family":"Amedofu","sequence":"additional","affiliation":[{"name":"Audiology Section Korle-Bu Teaching Hospital","place":["Ghana"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ambroise","family":"Wonkam","sequence":"additional","affiliation":[{"name":"University of Cape Town","place":["South Africa"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,11]]},"reference":[{"key":"e_1_3_4_2_1","first-page":"91","article-title":"Hearing-impairment among workers in a surface gold mining company in Ghana","volume":"9","author":"Amedofu GK","year":"2002","unstructured":"Amedofu GK. 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