{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:40:41Z","timestamp":1790736041930,"version":"4.1.0"},"reference-count":37,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["OMICS: A Journal of Integrative Biology"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic toggle=\"yes\">Candida tropicalis<\/jats:italic>\n                    belongs to the non-albicans group of Candida, and causes epidermal, mucosal, or systemic candidiasis in immunocompromised individuals. Although the prevalence of candidiasis has increased worldwide and non-albicans Candida (NAC) are becoming more significant, there are very few studies that focus on the NAC biology. Proteins and their post-translational modifications (PTMs) are an integral aspect in the pathobiology of such medically important fungi. Previously, we had reported the largest proteomic catalog of\n                    <jats:italic toggle=\"yes\">C. tropicalis<\/jats:italic>\n                    . Notably, PTMs can be identified from proteomics data without\n                    <jats:italic toggle=\"yes\">a priori<\/jats:italic>\n                    enrichment for a particular PTM, thus allowing broad-scale omics analyses. In this study, we developed the \u201cPTM-Pro,\u201d a graphical user interface-based tool for identification and summary of high-confidence PTM sites based on statistical threshold of users' choice. We mined available proteomic data of\n                    <jats:italic toggle=\"yes\">C. tropicalis<\/jats:italic>\n                    , and using PTM-Pro identified nearly 600 high-confidence PTM sites. The PTMs identified include phosphorylation of serine, threonine, and tyrosine; acetylation, crotonylation, methylation, and succinylation of lysine. These PTMs reside on biologically significant molecules, including histones, enzymes, and transcription factors. To our knowledge, this is the first report of PTMs in\n                    <jats:italic toggle=\"yes\">C. tropicalis<\/jats:italic>\n                    and lays a foundation for future investigations of\n                    <jats:italic toggle=\"yes\">C. tropicalis<\/jats:italic>\n                    PTMs. In addition, the PTM-Pro offers a graphical user interface tool for research on PTM sites in the field of proteomics.\n                  <\/jats:p>","DOI":"10.1089\/omi.2018.0093","type":"journal-article","created":{"date-parts":[[2018,8,14]],"date-time":"2018-08-14T10:51:14Z","timestamp":1534243874000},"page":"544-552","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Dissecting Candida Pathobiology: Post-Translational Modifications on the\n                    <i>Candida tropicalis<\/i>\n                    Proteome"],"prefix":"10.1177","volume":"22","author":[{"given":"Arun H.","family":"Patil","sequence":"first","affiliation":[{"name":"Yenepoya (Deemed to be University)","place":["India"]},{"name":"Institute of Bioinformatics","place":["India"]},{"name":"KIIT (Deemed to be University)","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keshava K.","family":"Datta","sequence":"additional","affiliation":[{"name":"Yenepoya (Deemed to be University)","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santosh Kumar","family":"Behera","sequence":"additional","affiliation":[{"name":"Yenepoya (Deemed to be University)","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Kasaragod","sequence":"additional","affiliation":[{"name":"Yenepoya (Deemed to be University)","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sneha M.","family":"Pinto","sequence":"additional","affiliation":[{"name":"Yenepoya (Deemed to be 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