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Although the hormones secreted from the pituitary have been well studied, comprehensive analyses of the pituitary proteome are limited. Pituitary proteomics is a field of postgenomic research that is crucial to understand human health and pituitary diseases. In this context, we report here a systematic proteomic profiling of human anterior pituitary gland (adenohypophysis) using high-resolution Fourier transform mass spectrometry. A total of 2164 proteins were identified in this study, of which 105 proteins were identified for the first time compared with high-throughput proteomic-based studies from human pituitary glands. In addition, we identified 480 proteins with secretory potential and 187\u2009N-terminally acetylated proteins. These are the first region-specific data that could serve as a vital resource for further investigations on the physiological role of the human anterior pituitary glands and the proteins secreted by them. We anticipate that the identification of previously unknown proteins in the present study will accelerate biomedical research to decipher their role in functioning of the human anterior pituitary gland and associated human diseases.<\/jats:p>","DOI":"10.1089\/omi.2018.0160","type":"journal-article","created":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T14:00:30Z","timestamp":1545314430000},"page":"759-769","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Proteomic Analysis of the Human Anterior Pituitary Gland"],"prefix":"10.1177","volume":"22","author":[{"given":"Soujanya D.","family":"Yelamanchi","sequence":"first","affiliation":[{"name":"Institute of Bioinformatics, International Technology Park, Bangalore, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ankur","family":"Tyagi","sequence":"additional","affiliation":[{"name":"Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Varshasnata","family":"Mohanty","sequence":"additional","affiliation":[{"name":"Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pinaki","family":"Dutta","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Postgraduate Institute of Medical Education and Research, Chandigarh, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rta","family":"Korbonits","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Barts and the London School of Medicine, Queen Mary University of London, London, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandip","family":"Chavan","sequence":"additional","affiliation":[{"name":"Institute of Bioinformatics, International Technology Park, Bangalore, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayshree","family":"Advani","sequence":"additional","affiliation":[{"name":"Institute of Bioinformatics, International Technology Park, Bangalore, India."},{"name":"Manipal Academy of Higher Education, Manipal, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anil K.","family":"Madugundu","sequence":"additional","affiliation":[{"name":"Institute of Bioinformatics, International Technology Park, Bangalore, India."},{"name":"Manipal Academy of Higher Education, Manipal, India."},{"name":"Center for Molecular Medicine, National Institute of Mental Health &amp; 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