{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T17:06:45Z","timestamp":1778605605330,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["OMICS: A Journal of Integrative Biology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic toggle=\"yes\">Elizabethkingia meningoseptica<\/jats:italic>\n                    is Gram-negative, rod-shaped opportunistic bacterial pathogen increasingly reported in hospital-acquired outbreaks. This bacterium is well known to thrive in the hospital environment. One of the leading causes of meningitis in pediatric and immune-compromised patients,\n                    <jats:italic toggle=\"yes\">E. meningoseptica<\/jats:italic>\n                    has been noted as a \u201cpathogen of interest\u201d in the context of nosocomial diseases associated with device-related infections in particular. This pathogen's multidrug-resistant phenotype and attendant lack of adequate molecular mechanistic data limit the current approaches for its effective management in hospitals and public health settings. This study provides the global proteome of\n                    <jats:italic toggle=\"yes\">E. meningoseptica<\/jats:italic>\n                    . The reference strain\n                    <jats:italic toggle=\"yes\">E. meningoseptica<\/jats:italic>\n                    ATCC 13253 was used for proteomic analysis using high-resolution Fourier transform mass spectrometry. The study provided translational evidence for 2506 proteins of\n                    <jats:italic toggle=\"yes\">E. meningoseptica<\/jats:italic>\n                    . We identified multiple metallo-\u03b2-lactamases, transcriptional regulators, and efflux transporter proteins associated with multidrug resistance. A protein Car D, which is an enzyme of the carbapenem synthesis pathway, was also discovered in\n                    <jats:italic toggle=\"yes\">E. meningoseptica<\/jats:italic>\n                    . Further, the proteomics data were harnessed for refining the genome annotation. We discovered 39 novel protein-coding genes and corrected four existing translations using proteogenomic workflow. Novel translations reported in this study enhance the molecular data on this organism, thus improving current databases. We believe that the in-depth proteomic data presented in this study offer a platform for accelerated research on this pathogen. The identification of multiple proteins, particularly those involved in drug resistance, offers new future opportunities to design novel and specific antibiotics against infections caused by\n                    <jats:italic toggle=\"yes\">E. meningoseptica<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1089\/omi.2019.0039","type":"journal-article","created":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T10:35:40Z","timestamp":1558607740000},"page":"318-326","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Global Proteome Profiling Reveals Drug-Resistant Traits in\n                    <i>Elizabethkingia meningoseptica<\/i>\n                    : An Opportunistic Nosocomial Pathogen"],"prefix":"10.1177","volume":"23","author":[{"given":"Archana","family":"Agrawal","sequence":"first","affiliation":[{"name":"Department of Neuromicrobiology, National Institute of Mental Health and Neurosciences, Bangalore, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raju","family":"Ravikumar","sequence":"additional","affiliation":[{"name":"Department of Neuromicrobiology, National Institute of Mental Health and Neurosciences, Bangalore, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chakrakodi N.","family":"Varun","sequence":"additional","affiliation":[{"name":"Department of Neuromicrobiology, National Institute of Mental Health and Neurosciences, Bangalore, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manish","family":"Kumar","sequence":"additional","affiliation":[{"name":"Institute of Bioinformatics, International Technology Park, Bangalore, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oishi","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Institute of Bioinformatics, International Technology Park, Bangalore, India."},{"name":"Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, India."},{"name":"School of Biotechnology, Amrita Vishwa Vidyapeetham, Kollam, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayshree","family":"Advani","sequence":"additional","affiliation":[{"name":"Institute of Bioinformatics, International Technology Park, Bangalore, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lathika","family":"Gopalakrishnan","sequence":"additional","affiliation":[{"name":"Institute of Bioinformatics, International Technology Park, Bangalore, India."},{"name":"Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, India."},{"name":"Manipal Academy of Higher Education, Manipal, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sowmya","family":"Nagaraj","sequence":"additional","affiliation":[{"name":"Department of Neuromicrobiology, National Institute of Mental Health and Neurosciences, Bangalore, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Varshasnata","family":"Mohanty","sequence":"additional","affiliation":[{"name":"Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arun H.","family":"Patil","sequence":"additional","affiliation":[{"name":"Institute of Bioinformatics, International Technology Park, Bangalore, India."},{"name":"Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, India."},{"name":"School of Biotechnology, KIIT (Deemed to be University), Bhubaneswar, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhuvaragavan","family":"Sreeramulu","sequence":"additional","affiliation":[{"name":"Department of Zoology, University 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