{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T17:32:06Z","timestamp":1787592726384,"version":"build-2736575974"},"reference-count":95,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["OMICS: A Journal of Integrative Biology"],"published-print":{"date-parts":[[2021,10,1]]},"abstract":"<jats:p>\n                    Breast invasive carcinoma (BIC) is one of the most commonly observed and the deadliest cancer among women. Studies examining the role of epigenetics and regulation of gene expression stand to make important strides in clinical management of BIC. In this context, messenger-RNA (mRNA) modification by regulatory proteins is noteworthy. Methylation of the adenosine base on the sixth nitrogen position is termed as N6-methyladenosine (m\n                    <jats:sup>6<\/jats:sup>\n                    A) modification, and this is the most abundant mRNA modification in mammals. Using several publicly available datasets, we report, in this study, comprehensive analyses and new findings on the impact of epitranscriptome regulatory factors and genetic alterations in m\n                    <jats:sup>6<\/jats:sup>\n                    A pathway genes on BIC. Accordingly, mutation frequency, type, and expression levels were determined. Importantly, we found that\n                    <jats:italic toggle=\"yes\">VIRMA<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">METTL14, RBM15B, EIF3B, YTHDF1<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">YTHDF3<\/jats:italic>\n                    genes hold potential significance as prognostic biomarker candidates as evidenced in particular by the overall survival analysis. Enrichment of gene ontology (GO) terms and KEGG pathways for the tumor samples with genetic alterations in the epitranscriptome regulatory pathways were investigated. Dysregulation of regulatory factors in breast cancer was associated with cell division, and survival-related pathways such as \u201cnuclear division,\u201d and \u201cchromosome segregation.\u201d Hence, the gained overactivity of these pathways may account for BIC's poor prognosis. In conclusion, these data underscore that m\n                    <jats:sup>6<\/jats:sup>\n                    A pathway regulators are frequently mutated in BIC and likely play a significant role in disease pathogenesis. Epitranscriptome pathway genes warrant further research attention as regulators of cancer growth and biological targets in BIC, and with an eye to personalized medicine in clinical oncology.\n                  <\/jats:p>","DOI":"10.1089\/omi.2021.0114","type":"journal-article","created":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T12:18:55Z","timestamp":1631621935000},"page":"660-678","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["m\n                    <sup>6<\/sup>\n                    A Pathway Regulators Are Frequently Mutated in Breast Invasive Carcinoma and May Play an Important Role in Disease Pathogenesis"],"prefix":"10.1177","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2424-9893","authenticated-orcid":false,"given":"Turan","family":"Demircan","sequence":"first","affiliation":[{"name":"Medical Biology Department, School of Medicine, Mu\u011fla S\u0131tk\u0131 Ko\u00e7man University, Mu\u011fla, Turkey."},{"name":"Department of Bioinformatics, Institute of Natural Sciences, Mu\u011fla S\u0131tk\u0131 Ko\u00e7man University, Mu\u011fla, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mervenur","family":"Yavuz","sequence":"additional","affiliation":[{"name":"Medical Biology, Institute of Health Sciences, Mu\u011fla S\u0131tk\u0131 Ko\u00e7man University, Mu\u011fla, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u0131dd\u0131ka","family":"Akg\u00fcl","sequence":"additional","affiliation":[{"name":"Biophysics, Institute of Health Sciences, Adnan Menderes University, Ayd\u0131n, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,10,12]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601603"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-018-1757-3"},{"key":"e_1_3_4_4_1","first-page":"2546","article-title":"The m6A readers YTHDF1 and YTHDF3 aberrations associated with metastasis and predict poor prognosis in breast cancer patients","volume":"10","author":"Anita R","year":"2020","unstructured":"Anita R, , Paramasivam A, , Priyadharsini JV, , and Chitra S. 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