{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:56:09Z","timestamp":1777928169655,"version":"3.51.4"},"reference-count":149,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["OMICS: A Journal of Integrative Biology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:p>The human hypothalamus is central to the regulation of neuroendocrine and neurovegetative systems, as well as modulation of chronobiology and behavioral aspects in human health and disease. Surprisingly, a deep proteomic analysis of the normal human hypothalamic proteome has been missing for such an important organ so far. In this study, we delineated the human hypothalamus proteome using a high-resolution mass spectrometry approach which resulted in the identification of 5349 proteins, while a multiple post-translational modification (PTM) search identified 191 additional proteins, which were missed in the first search. A proteogenomic analysis resulted in the discovery of multiple novel protein-coding regions as we identified proteins from noncoding regions (pseudogenes) and proteins translated from short open reading frames that can be missed using the traditional pipeline of prediction of protein-coding genes as a part of genome annotation. We also identified several PTMs of hypothalamic proteins that may be required for normal hypothalamic functions. Moreover, we observed an enrichment of proteins pertaining to autophagy and adult neurogenesis in the proteome data. We believe that the hypothalamic proteome reported herein would help to decipher the molecular basis for the diverse range of physiological functions attributed to it, as well as its role in neurological and psychiatric diseases. Extensive proteomic profiling of the hypothalamic nuclei would further elaborate on the role and functional characterization of several hypothalamus-specific proteins and pathways to inform future research and clinical discoveries in biological psychiatry, neurology, and system biology.<\/jats:p>","DOI":"10.1089\/omi.2021.0158","type":"journal-article","created":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T11:45:09Z","timestamp":1635507909000},"page":"693-710","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["The Normal Human Adult Hypothalamus Proteomic Landscape: Rise of Neuroproteomics in Biological Psychiatry and Systems Biology"],"prefix":"10.1177","volume":"25","author":[{"given":"Oishi","family":"Chatterjee","sequence":"first","affiliation":[{"name":"Institute of Bioinformatics, Bangalore India."},{"name":"Amrita School of Biotechnology, Amrita University, Kollam, India."},{"name":"Center for Systems Biology and Molecular Medicine, Yenepoya Research Center, Yenepoya (Deemed to be University), Mangalore, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lathika","family":"Gopalakrishnan","sequence":"additional","affiliation":[{"name":"Institute of Bioinformatics, Bangalore India."},{"name":"Center for Systems Biology and Molecular Medicine, Yenepoya Research Center, Yenepoya (Deemed to be University), Mangalore, India."},{"name":"Manipal Academy of Higher Education, Manipal, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Praseeda","family":"Mol","sequence":"additional","affiliation":[{"name":"Institute of Bioinformatics, Bangalore India."},{"name":"Amrita School of Biotechnology, Amrita University, Kollam, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayshree","family":"Advani","sequence":"additional","affiliation":[{"name":"Institute of Bioinformatics, Bangalore India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bipin","family":"Nair","sequence":"additional","affiliation":[{"name":"Amrita School of Biotechnology, Amrita University, Kollam, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susarla Krishna","family":"Shankar","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore, India."},{"name":"Human Brain Tissue Repository, National Institute of Mental Health and Neurosciences, Bangalore, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Mahadevan","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore, India."},{"name":"Human Brain Tissue Repository, National Institute of Mental Health and Neurosciences, Bangalore, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6206-2384","authenticated-orcid":false,"given":"Thottethodi Subrahmanya Keshava","family":"Prasad","sequence":"additional","affiliation":[{"name":"Center for Systems Biology and Molecular Medicine, Yenepoya Research Center, Yenepoya (Deemed to be University), Mangalore, India."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,11,8]]},"reference":[{"key":"e_1_3_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2008.08.005"},{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-019-0036-z"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C300557200"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2021.0082"},{"key":"e_1_3_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2015.12.006"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3881"},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3276383"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2008.01.006"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-018-2849-3"},{"key":"e_1_3_5_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-012-0300-4"},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-013-1104-z"},{"key":"e_1_3_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2012.12.008"},{"key":"e_1_3_5_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-008-0498-1"},{"key":"e_1_3_5_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr800394e"},{"key":"e_1_3_5_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0510710103"},{"key":"e_1_3_5_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1003"},{"key":"e_1_3_5_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12079-016-0353-7"},{"key":"e_1_3_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2006.11.041"},{"key":"e_1_3_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2013.05.001"},{"key":"e_1_3_5_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004695"},{"key":"e_1_3_5_22_1","doi-asserted-by":"publisher","DOI":"10.3340\/jkns.2007.42.6.470"},{"key":"e_1_3_5_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1175371"},{"key":"e_1_3_5_24_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI31516"},{"key":"e_1_3_5_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201000423"},{"key":"e_1_3_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2009.11.017"},{"key":"e_1_3_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2016.08.002"},{"key":"e_1_3_5_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-014-0171-1"},{"key":"e_1_3_5_29_1","doi-asserted-by":"crossref","unstructured":"Dagamajalu S Rex DAB Philem PD Rainey JK and Keshava Prasad TS. (2021). A network map of apelin-mediated signaling. J Cell Commun Signal (online ahead of print).","DOI":"10.1007\/s12079-021-00614-6"},{"key":"e_1_3_5_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2019.05.015"},{"key":"e_1_3_5_31_1","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2021.0054"},{"key":"e_1_3_5_32_1","doi-asserted-by":"publisher","DOI":"10.3233\/BPL-170047"},{"key":"e_1_3_5_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2012.12.005"},{"key":"e_1_3_5_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth785"},{"key":"e_1_3_5_35_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00088.2001"},{"key":"e_1_3_5_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00540"},{"key":"e_1_3_5_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0020052"},{"key":"e_1_3_5_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2011.03.014"},{"key":"e_1_3_5_39_1","first-page":"239","article-title":"Induction of neurite outgrowth by MAP kinase in PC12 cells","volume":"11","author":"Fukuda M","year":"1995","unstructured":"Fukuda M, , Gotoh Y, , Tachibana T, et al. (1995). Induction of neurite outgrowth by MAP kinase in PC12 cells. Oncogene, 11, 239\u2013244.","journal-title":"Oncogene"},{"key":"e_1_3_5_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2018.06.020"},{"key":"e_1_3_5_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00813"},{"key":"e_1_3_5_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2004.11.005"},{"key":"e_1_3_5_43_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2017-315795"},{"key":"e_1_3_5_44_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0804340105"},{"key":"e_1_3_5_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1985.tb07229.x"},{"key":"e_1_3_5_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004254"},{"key":"e_1_3_5_47_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.261358698"},{"key":"e_1_3_5_48_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2014-1257"},{"key":"e_1_3_5_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2017.06.010"},{"key":"e_1_3_5_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(94)00189-7"},{"key":"e_1_3_5_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201300073"},{"key":"e_1_3_5_52_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.6.6.12709"},{"key":"e_1_3_5_53_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-11-260"},{"key":"e_1_3_5_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201300064"},{"key":"e_1_3_5_55_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00630.2015"},{"key":"e_1_3_5_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2009.03.010"},{"key":"e_1_3_5_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410200214"},{"key":"e_1_3_5_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/0929-7855(96)00545-7"},{"key":"e_1_3_5_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.06.008"},{"key":"e_1_3_5_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13302"},{"key":"e_1_3_5_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2006.06.026"},{"key":"e_1_3_5_62_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3984-05.2005"},{"key":"e_1_3_5_63_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1995.65041445.x"},{"key":"e_1_3_5_64_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1404726"},{"key":"e_1_3_5_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1987.tb05707.x"},{"key":"e_1_3_5_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00971601"},{"key":"e_1_3_5_67_1","first-page":"379","article-title":"The role of the hypothalamus in neuroendocrinology","author":"Koizumi K","year":"1996","unstructured":"Koizumi K. (1996). The role of the hypothalamus in neuroendocrinology. In: Comprehensive Human Physiology. Greger, Rainer, Windhors, and Uwe, eds. Springer: Berlin,, Heidelberg, 379\u2013401.","journal-title":"In: Comprehensive Human Physiology. Greger, Rainer, Windhors, and Uwe, eds. Springer: Berlin,"},{"key":"e_1_3_5_68_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1115360"},{"key":"e_1_3_5_69_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200412022"},{"key":"e_1_3_5_70_1","unstructured":"Koopmans F van Nierop P Andres-Alonso M et al. (2019). SynGO: an evidence-based expert-curated knowledge base for the synapse. Neuron 103 217.e4\u2013234.e4."},{"key":"e_1_3_5_71_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871527311312050010"},{"key":"e_1_3_5_72_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.RA118.000696"},{"key":"e_1_3_5_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3079"},{"key":"e_1_3_5_74_1","doi-asserted-by":"publisher","DOI":"10.4103\/2152-7806.110667"},{"key":"e_1_3_5_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/0898-6568(93)90031-G"},{"key":"e_1_3_5_76_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2012.00024"},{"key":"e_1_3_5_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1867"},{"key":"e_1_3_5_78_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2018-00536"},{"key":"e_1_3_5_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2207"},{"key":"e_1_3_5_80_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-015-0742-x"},{"key":"e_1_3_5_81_1","first-page":"440","article-title":"Neurodevelopmental origin and adult neurogenesis of the neuroendocrine hypothalamus","volume":"8","author":"Maggi R","year":"2014","unstructured":"Maggi R, , Zasso J, , and Conti L. (2014). Neurodevelopmental origin and adult neurogenesis of the neuroendocrine hypothalamus. Front Cell Neurosci, 8, 440.","journal-title":"Front Cell Neurosci"},{"key":"e_1_3_5_82_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0178787"},{"key":"e_1_3_5_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2010.82"},{"key":"e_1_3_5_84_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M605488200"},{"key":"e_1_3_5_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2014.11.004"},{"key":"e_1_3_5_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02440"},{"key":"e_1_3_5_87_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200600072"},{"key":"e_1_3_5_88_1","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2020.0020"},{"key":"e_1_3_5_89_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073858414526645"},{"key":"e_1_3_5_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2012.08.004"},{"key":"e_1_3_5_91_1","doi-asserted-by":"publisher","DOI":"10.1677\/JOE-09-0093"},{"key":"e_1_3_5_92_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4714-13.2014"},{"key":"e_1_3_5_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10607"},{"key":"e_1_3_5_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08455"},{"key":"e_1_3_5_95_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-015-0995-x"},{"key":"e_1_3_5_96_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2016.1215382"},{"key":"e_1_3_5_97_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M600297-MCP200"},{"key":"e_1_3_5_98_1","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2021.0047"},{"key":"e_1_3_5_99_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-014-8773-y"},{"key":"e_1_3_5_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2016.11.009"},{"key":"e_1_3_5_101_1","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2018.0093"},{"key":"e_1_3_5_102_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-5956-10-26"},{"key":"e_1_3_5_103_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-17-06706.2001"},{"key":"e_1_3_5_104_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2479-09.2010"},{"key":"e_1_3_5_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(99)00276-1"},{"key":"e_1_3_5_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2016.05.003"},{"key":"e_1_3_5_107_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011-1882"},{"key":"e_1_3_5_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(03)02350-3"},{"key":"e_1_3_5_109_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac026117i"},{"key":"e_1_3_5_110_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.6.1502"},{"key":"e_1_3_5_111_1","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2021.0050"},{"key":"e_1_3_5_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2016.4"},{"key":"e_1_3_5_113_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-014-0058-5"},{"key":"e_1_3_5_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2349"},{"key":"e_1_3_5_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1964"},{"key":"e_1_3_5_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2012.10.059"},{"key":"e_1_3_5_117_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-0899"},{"key":"e_1_3_5_118_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-014-0070-5"},{"key":"e_1_3_5_119_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10098"},{"key":"e_1_3_5_120_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.21.2.595-602.2001"},{"key":"e_1_3_5_121_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1120"},{"key":"e_1_3_5_122_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2006.8.4\/ssmith"},{"key":"e_1_3_5_123_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019745"},{"key":"e_1_3_5_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2013.10.005"},{"key":"e_1_3_5_125_1","first-page":"111","article-title":"Transcriptome-wide identification of preferentially expressed genes in the hypothalamus and pituitary gland","volume":"2","author":"St-Amand J","year":"2011","unstructured":"St-Amand J, , Yoshioka M, , Tanaka K, , and Nishida Y. (2011). Transcriptome-wide identification of preferentially expressed genes in the hypothalamus and pituitary gland. Front Endocrinol (Lausanne), 2, 111.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"e_1_3_5_126_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201100642"},{"key":"e_1_3_5_127_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2002.6575"},{"key":"e_1_3_5_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gpb.2016.09.002"},{"key":"e_1_3_5_129_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.026609"},{"key":"e_1_3_5_130_1","first-page":"73","article-title":"The human hypothalamus: a morpho-functional perspective","volume":"27","author":"Toni R","year":"2004","unstructured":"Toni R, , Malaguti A, , Benfenati F, , and Martini L. (2004). The human hypothalamus: a morpho-functional perspective. J Endocrinol Invest, 27, 73\u201394.","journal-title":"J Endocrinol Invest"},{"key":"e_1_3_5_131_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.37720"},{"key":"e_1_3_5_132_1","doi-asserted-by":"publisher","DOI":"10.3390\/clockssleep3010012"},{"key":"e_1_3_5_133_1","doi-asserted-by":"publisher","DOI":"10.2337\/db16-1106"},{"key":"e_1_3_5_134_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2018.00002"},{"key":"e_1_3_5_135_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.10.2424"},{"key":"e_1_3_5_136_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02918896"},{"key":"e_1_3_5_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-3806(02)00509-6"},{"key":"e_1_3_5_138_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2015.406"},{"key":"e_1_3_5_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2004.12.021"},{"key":"e_1_3_5_140_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.358"},{"key":"e_1_3_5_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2018.04.001"},{"key":"e_1_3_5_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.02.087"},{"key":"e_1_3_5_143_1","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2011.0118"},{"key":"e_1_3_5_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.05.060"},{"key":"e_1_3_5_145_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12143"},{"key":"e_1_3_5_146_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001112"},{"key":"e_1_3_5_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2010.03.001"},{"key":"e_1_3_5_148_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2019.01296"},{"key":"e_1_3_5_149_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1616255114"},{"key":"e_1_3_5_150_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4899-09.2010"}],"container-title":["OMICS: A Journal of Integrative Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/omi.2021.0158","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/omi.2021.0158","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/omi.2021.0158","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:05:11Z","timestamp":1777676711000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/omi.2021.0158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":149,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1089\/omi.2021.0158"],"URL":"https:\/\/doi.org\/10.1089\/omi.2021.0158","relation":{},"ISSN":["1536-2310","1557-8100"],"issn-type":[{"value":"1536-2310","type":"print"},{"value":"1557-8100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11]]}}}