{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:55:43Z","timestamp":1777928143037,"version":"3.51.4"},"reference-count":130,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["OMICS: A Journal of Integrative Biology"],"published-print":{"date-parts":[[2022,1,1]]},"abstract":"<jats:p>\n                    Hearing impairment (HI) is a silent planetary health crisis that requires attention worldwide. The prevalence of HI in South Africa is estimated as 5.5 in 100 live births, which is about 5 times higher than the prevalence in high-income countries. This also offers opportunity to drive progressive science, technology and innovation policy, and health systems. We present here a systematic analysis and review on the prevalence, etiologies, clinical patterns, and genetics\/genomics of HI in South Africa. We searched PubMed, Scopus, African Journals Online, AFROLIB, and African Index Medicus to identify the pertinent studies on HI in South Africa, published from inception to April 30, 2021, and the data were summarized narratively. We screened 944 records, of which 27 studies were included in the review. The age at diagnosis is \u223c3 years of age and the most common factor associated with acquired HI was middle ear infections. There were numerous reports on medication toxicity, with kanamycin-induced ototoxicity requiring specific attention when considering the high burden of tuberculosis in South Africa. The Waardenburg Syndrome is the most common reported syndromic HI. The Usher Syndrome is the only syndrome with genetic investigations, whereby a founder mutation was identified among black South Africans (\n                    <jats:italic toggle=\"yes\">MYO7A<\/jats:italic>\n                    -c.6377delC).\n                    <jats:italic toggle=\"yes\">GJB2<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">GJB6<\/jats:italic>\n                    genes are not major contributors to nonsyndromic HI among Black South Africans. Furthermore, emerging data using targeted panel sequencing have shown a low resolution rate in Black South Africans in known HI genes. Importantly, mutations in known nonsyndromic HI genes are infrequent in South Africa. Therefore, whole-exome sequencing appears as the most effective way forward to identify variants associated with HI in South Africa. Taken together, this article contributes to the emerging field of planetary health genomics with a focus on HI and offers new insights and lessons learned for future roadmaps on genomics\/multiomics and clinical studies of HI around the world.\n                  <\/jats:p>","DOI":"10.1089\/omi.2021.0181","type":"journal-article","created":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T16:43:38Z","timestamp":1642524218000},"page":"2-18","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Hearing Impairment in South Africa and the Lessons Learned for Planetary Health Genomics: A Systematic Review"],"prefix":"10.1177","volume":"26","author":[{"given":"Noluthando","family":"Manyisa","sequence":"first","affiliation":[{"name":"Division of Human Genetics, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel Mawuli","family":"Adadey","sequence":"additional","affiliation":[{"name":"Division of Human Genetics, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa."},{"name":"West African Centre for Cell Biology of Infectious Pathogens, College of Basic and Applied Sciences, University of Ghana, Accra, Ghana."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edmond","family":"Wonkam-Tingang","sequence":"additional","affiliation":[{"name":"Division of Human Genetics, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdoulaye","family":"Yalcouye","sequence":"additional","affiliation":[{"name":"Division of Human Genetics, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa."},{"name":"Department of Neurology, Point G Teaching Hospital, University of Sciences, Techniques and Technology, Bamako, Mali."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1420-9051","authenticated-orcid":false,"given":"Ambroise","family":"Wonkam","sequence":"additional","affiliation":[{"name":"Division of Human Genetics, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,1,18]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/1596-3519.76573"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0297-157"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0161893"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2019.00841"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(00)00535-7"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-2333"},{"key":"e_1_3_4_8_1","first-page":"e1","article-title":"An audiological profile of patients infected with multi-drug resistant tuberculosis at a district hospital in KwaZulu-Natal","volume":"63","author":"Appana D","year":"2016","unstructured":"Appana D, , Joseph L, , and Paken J. 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