{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:56:10Z","timestamp":1777928170724,"version":"3.51.4"},"reference-count":142,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["OMICS: A Journal of Integrative Biology"],"published-print":{"date-parts":[[2022,3,1]]},"abstract":"<jats:p>Innovation roadmaps are important, because they encourage the actors in an innovation ecosystem to creatively imagine multiple possible science future(s), while anticipating the prospects and challenges on the innovation trajectory. In this overarching context, this expert review highlights the present unmet need for therapeutic innovations for pituitary neuroendocrine tumors (PitNETs), also known as pituitary adenomas. Although there are many drugs used in practice to treat PitNETs, many of these drugs can have negative side effects and show highly variable outcomes in terms of overall recovery. Building innovation roadmaps for PitNETs' treatments can allow incorporation of systems biology approaches to bring about insights at multiple levels of cell biology, from genes to proteins to metabolites. Using the systems biology techniques, it will then be possible to offer potential therapeutic strategies for the convergence of preventive approaches and patient-centered disease treatment. Here, we first provide a comprehensive overview of the molecular subtypes of PitNETs and therapeutics for these tumors from the past to the present. We then discuss examples of clinical trials and drug repositioning studies and how multi-omics studies can help in discovery and rational development of new therapeutics for PitNETs. Finally, this expert review offers new public health and personalized medicine approaches on cases that are refractory to conventional treatment or recur despite currently used surgical and\/or drug therapy.<\/jats:p>","DOI":"10.1089\/omi.2021.0221","type":"journal-article","created":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T17:53:04Z","timestamp":1645033984000},"page":"115-129","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Past, Present, and Future of Therapies for Pituitary Neuroendocrine Tumors: Need for Omics and Drug Repositioning Guidance"],"prefix":"10.1177","volume":"26","author":[{"given":"Busra","family":"Aydin","sequence":"first","affiliation":[{"name":"Department of Bioengineering, Faculty of Engineering, Marmara University, Istanbul, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esra","family":"Yildirim","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Faculty of Engineering, Marmara University, Istanbul, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Onur","family":"Erdogan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, School of Medicine, Marmara University, Istanbul, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6036-1348","authenticated-orcid":false,"given":"Kazim Yalcin","family":"Arga","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Faculty of Engineering, Marmara University, Istanbul, Turkey."},{"name":"Genetic and Metabolic Diseases Research and Investigation Center, Marmara University, Istanbul, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betul Karademir","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Genetic and Metabolic Diseases Research and Investigation Center, Marmara University, Istanbul, Turkey."},{"name":"Department of Biochemistry and School of Medicine, Marmara University, Istanbul, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suheyla Uyar","family":"Bozkurt","sequence":"additional","affiliation":[{"name":"Department of Medical Pathology, School of Medicine, Marmara University, Istanbul, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatih","family":"Bayrakli","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, School of Medicine, Marmara University, Istanbul, Turkey."},{"name":"Institute of Neurological Sciences, Marmara University, Istanbul, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1330-9712","authenticated-orcid":false,"given":"Beste","family":"Turanli","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Faculty of Engineering, Marmara University, Istanbul, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,3,8]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt0712-571a"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01735795"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.9"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-016-0863-3"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.16556"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm11040271"},{"key":"e_1_3_4_8_1","first-page":"1","article-title":"Tumor microenvironment","volume":"56","author":"Arneth B","year":"2020","unstructured":"Arneth B. (2020). Tumor microenvironment. Medicina (Lithuania), 56, 1.","journal-title":"Medicina (Lithuania)"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1468"},{"key":"e_1_3_4_10_1","first-page":"611","article-title":"Omics-driven biomarkers of psoriasis: Recent insights, current challenges, and future prospects","volume":"13","author":"Aydin B","year":"2020","unstructured":"Aydin B, , Arga KY, , and Karadag AS. (2020). Omics-driven biomarkers of psoriasis: Recent insights, current challenges, and future prospects. Clin Cosmet, 13, 611\u2013625.","journal-title":"Clin Cosmet"},{"key":"e_1_3_4_11_1","article-title":"miRNA-mediated drug repurposing unveiled potential candidate drugs for prolactinoma treatment","author":"Aydin B","year":"2021","unstructured":"Aydin B, , Arslan S, , Bayrakl\u0131 F, , Karademir B, , and Arga KY. (2021). miRNA-mediated drug repurposing unveiled potential candidate drugs for prolactinoma treatment. Neuroendocrinology. [Epub ahead of print]; DOI: 10.1159\/000515801.","journal-title":"Neuroendocrinology"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.2217\/ije-2020-0002"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.02075"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0000000000000505"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-12-0358"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000351007"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.01273"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-012-0382-z"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-59-1-25"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2009.06.001"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2002.01549.x"},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/CAD.0000000000000856"},{"key":"e_1_3_4_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/js.2018-00269"},{"key":"e_1_3_4_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2006.02562.x"},{"key":"e_1_3_4_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-3628"},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:PITU.0000004802.47010.00"},{"key":"e_1_3_4_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2019.101290"},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-2480"},{"key":"e_1_3_4_29_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1105743"},{"key":"e_1_3_4_30_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa805"},{"key":"e_1_3_4_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-013-0093-x"},{"key":"e_1_3_4_32_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-19-0279"},{"key":"e_1_3_4_33_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-14-0300"},{"key":"e_1_3_4_34_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-1668"},{"key":"e_1_3_4_35_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-2616"},{"key":"e_1_3_4_36_1","first-page":"51","article-title":"Drug repositioning: A review","volume":"4","author":"Deotarse PP","year":"2015","unstructured":"Deotarse PP, , Jain AS, , Baile MB, , Kolhe NS, , and Kulkarni AA. (2015). Drug repositioning: A review. Int J Pharm Sci Rev Res, 4, 51\u201358.","journal-title":"Int J Pharm Sci Rev Res"},{"key":"e_1_3_4_37_1","doi-asserted-by":"publisher","DOI":"10.2217\/cns-2016-0011"},{"key":"e_1_3_4_38_1","first-page":"3542","article-title":"Emergency and prolonged use of intravenous etomidate to control hypercortisolemia in a patient with Cushing's syndrome and peritonitis","volume":"83","author":"Drake WM","year":"1998","unstructured":"Drake WM, , Perry LA, , Hinds CJ, et al. (1998). Emergency and prolonged use of intravenous etomidate to control hypercortisolemia in a patient with Cushing's syndrome and peritonitis. J Clin Endocrinol Metab, 83, 3542\u20133544.","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_3_4_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku476"},{"key":"e_1_3_4_40_1","first-page":"82","article-title":"The prince and the pauper","volume":"7","author":"Duenas-Gonzalez A","year":"2008","unstructured":"Duenas-Gonzalez A, , Garcia-Lopez P, , Herrera LA, et al. (2008). The prince and the pauper. A tale of anticancer targeted agents. Molecular Cancer, 7, 82.","journal-title":"A tale of anticancer targeted agents. Molecular Cancer"},{"key":"e_1_3_4_41_1","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2020.0042"},{"key":"e_1_3_4_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9081896"},{"key":"e_1_3_4_43_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgz211"},{"key":"e_1_3_4_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-018-0865-7"},{"key":"e_1_3_4_45_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-3126"},{"key":"e_1_3_4_46_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-3350"},{"key":"e_1_3_4_47_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1843"},{"key":"e_1_3_4_48_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP12149.RA"},{"key":"e_1_3_4_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-013-1151-1"},{"key":"e_1_3_4_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30610-0"},{"key":"e_1_3_4_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt279"},{"key":"e_1_3_4_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-011-0370-8"},{"key":"e_1_3_4_53_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2005-9998"},{"key":"e_1_3_4_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1982.tb00718.x"},{"key":"e_1_3_4_55_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-17-0216"},{"key":"e_1_3_4_56_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-16-0206"},{"key":"e_1_3_4_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-015-0685-8"},{"key":"e_1_3_4_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-012-0454-0"},{"key":"e_1_3_4_59_1","doi-asserted-by":"publisher","DOI":"10.1210\/jendso\/bvaa046.895"},{"key":"e_1_3_4_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0889-1"},{"key":"e_1_3_4_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2013.12.001"},{"key":"e_1_3_4_62_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa497"},{"key":"e_1_3_4_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2011.11.010"},{"key":"e_1_3_4_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173594"},{"key":"e_1_3_4_65_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13321-020-00450-7"},{"key":"e_1_3_4_66_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-2700"},{"key":"e_1_3_4_67_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389200219666180416161846"},{"key":"e_1_3_4_68_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.85.4.6548"},{"key":"e_1_3_4_69_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12020308"},{"key":"e_1_3_4_70_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-16-0979"},{"key":"e_1_3_4_71_1","doi-asserted-by":"publisher","DOI":"10.1186\/1752-0509-6-80"},{"key":"e_1_3_4_72_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-2361"},{"key":"e_1_3_4_73_1","volume-title":"WHO Classification of Tumours of Endocrine Organs","author":"Lloyd R","year":"2017","unstructured":"Lloyd R, , Osamura R, , Kloppel GRJ. (2017). WHO Classification of Tumours of Endocrine Organs. Lyon International Agency for Research on Cancer: Lyon, France."},{"key":"e_1_3_4_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2015.10.029"},{"key":"e_1_3_4_75_1","doi-asserted-by":"publisher","DOI":"10.3171\/2016.1.JNS152119"},{"key":"e_1_3_4_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-017-1769-8"},{"key":"e_1_3_4_77_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197903013000903"},{"key":"e_1_3_4_78_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-4376"},{"key":"e_1_3_4_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-011-1442-6"},{"key":"e_1_3_4_80_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-19-0327"},{"key":"e_1_3_4_81_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-020-02478-z"},{"key":"e_1_3_4_82_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.13052"},{"key":"e_1_3_4_83_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-17-0933"},{"key":"e_1_3_4_84_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra062453"},{"key":"e_1_3_4_85_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-009-0191-1"},{"key":"e_1_3_4_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2007.02825.x"},{"key":"e_1_3_4_87_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-013-1270-8"},{"key":"e_1_3_4_88_1","doi-asserted-by":"publisher","DOI":"10.1093\/database\/baw083"},{"key":"e_1_3_4_89_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-022049"},{"key":"e_1_3_4_90_1","first-page":"57","article-title":"Therapeutic drug repurposing, repositioning and rescue: Part II: Business review","volume":"16","author":"Naylor S","year":"2015","unstructured":"Naylor S, , Kauppi DM, , and Schonfeld JM. (2015). Therapeutic drug repurposing, repositioning and rescue: Part II: Business review. Drug Discov World, 16, 57\u201372.","journal-title":"Drug Discov World"},{"key":"e_1_3_4_91_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-010-0289-5"},{"key":"e_1_3_4_92_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-1818"},{"key":"e_1_3_4_93_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-015-0727-2"},{"key":"e_1_3_4_94_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-3362"},{"key":"e_1_3_4_95_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-2758"},{"key":"e_1_3_4_96_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noaa200"},{"key":"e_1_3_4_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(20)30240-0"},{"key":"e_1_3_4_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(16)00086-3"},{"key":"e_1_3_4_99_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030859"},{"key":"e_1_3_4_100_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-11-0737"},{"key":"e_1_3_4_101_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-12-0274"},{"key":"e_1_3_4_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2018.168"},{"key":"e_1_3_4_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2013.05.004"},{"key":"e_1_3_4_104_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-0537"},{"key":"e_1_3_4_105_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022356313153"},{"key":"e_1_3_4_106_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-17-0796"},{"key":"e_1_3_4_107_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-012-0460-2"},{"key":"e_1_3_4_108_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-2443"},{"key":"e_1_3_4_109_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8050695"},{"key":"e_1_3_4_110_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-70-5-1426"},{"key":"e_1_3_4_111_1","volume-title":"In Silico Databases and Tools for Drug Repurposing","author":"Sercinoglu O","year":"2019","unstructured":"Sercinoglu O, , and Ozbek Sar\u0131ca P. (2019). In Silico Databases and Tools for Drug Repurposing. Academic Press, Elsevier Inc: London, United Kingdom."},{"key":"e_1_3_4_112_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.9224"},{"key":"e_1_3_4_113_1","doi-asserted-by":"publisher","DOI":"10.1159\/000475436"},{"key":"e_1_3_4_114_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-018-1638-9"},{"key":"e_1_3_4_115_1","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2020.1704729"},{"key":"e_1_3_4_116_1","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2021.1883585"},{"key":"e_1_3_4_117_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-14-0144"},{"key":"e_1_3_4_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2017.02.052"},{"key":"e_1_3_4_119_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-013-1269-1"},{"key":"e_1_3_4_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nec.2019.05.007"},{"key":"e_1_3_4_121_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12020514"},{"key":"e_1_3_4_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2019.09.020"},{"key":"e_1_3_4_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-816125-8.00027-4"},{"key":"e_1_3_4_124_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00500"},{"key":"e_1_3_4_125_1","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2017.0127"},{"key":"e_1_3_4_126_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2019.00420"},{"key":"e_1_3_4_127_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612824666181106095959"},{"key":"e_1_3_4_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.03.009"},{"key":"e_1_3_4_129_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-2508"},{"key":"e_1_3_4_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06844-1"},{"key":"e_1_3_4_131_1","doi-asserted-by":"publisher","DOI":"10.1159\/000500812"},{"key":"e_1_3_4_132_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2019-00056"},{"key":"e_1_3_4_133_1","doi-asserted-by":"publisher","DOI":"10.1159\/000505923"},{"key":"e_1_3_4_134_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-19-2154"},{"key":"e_1_3_4_135_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-009-0209-8"},{"key":"e_1_3_4_136_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq1037"},{"key":"e_1_3_4_137_1","doi-asserted-by":"publisher","DOI":"10.1159\/000497746"},{"key":"e_1_3_4_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2018.12.174"},{"key":"e_1_3_4_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2016.01.043"},{"key":"e_1_3_4_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2015.09.017"},{"key":"e_1_3_4_141_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-20-0136"},{"key":"e_1_3_4_142_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-00284-7"},{"key":"e_1_3_4_143_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-02461"}],"container-title":["OMICS: A Journal of Integrative Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/omi.2021.0221","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/omi.2021.0221","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/omi.2021.0221","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:05:23Z","timestamp":1777676723000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/omi.2021.0221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,1]]},"references-count":142,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3,1]]}},"alternative-id":["10.1089\/omi.2021.0221"],"URL":"https:\/\/doi.org\/10.1089\/omi.2021.0221","relation":{},"ISSN":["1536-2310","1557-8100"],"issn-type":[{"value":"1536-2310","type":"print"},{"value":"1557-8100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,1]]}}}