{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:56:19Z","timestamp":1777928179268,"version":"3.51.4"},"reference-count":116,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["OMICS: A Journal of Integrative Biology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:p>COVID-19 is a systemic disease affecting multiple organ systems and caused by infection with the SARS-CoV-2 virus. Two years into the COVID-19 pandemic and after the introduction of several vaccines, the pandemic continues to evolve in part owing to global inequities in access to preventive and therapeutic measures. We are also witnessing the introduction of antivirals against COVID-19. Against this current background, we review the progress made with nanotechnology-based approaches such as nanoformulations to combat the multiorgan effects of SARS-CoV-2 infection from a systems medicine lens. While nanotechnology has previously been widely utilized in the antiviral research domain, it has not yet received the commensurate interest in the case of COVID-19 pandemic response strategies. Notably, SARS-CoV-2 and nanomaterials are similar in size ranging from 50 to 200\u2009nm. Nanomaterials offer the promise to reduce the side effects of antiviral drugs, codeliver multiple drugs while maintaining stability in the biological milieu, and sustain the release of entrapped drug(s) for a predetermined time period, to name but a few conceivable scenarios, wherein nanotechnology can enable and empower preventive medicine and therapeutic innovations against SARS-CoV-2. We conclude the article by underlining that nanotechnology-based interventions warrant further consideration to enable precision planetary health responses against the COVID-19 pandemic.<\/jats:p>","DOI":"10.1089\/omi.2022.0072","type":"journal-article","created":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T10:24:21Z","timestamp":1661855061000},"page":"473-488","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Nanotechnology and COVID-19 Convergence: Toward New Planetary Health Interventions Against the Pandemic"],"prefix":"10.1177","volume":"26","author":[{"given":"Panchanan","family":"Sahoo","sequence":"first","affiliation":[{"name":"Kalinga Institute of Medical Sciences, Kalinga Institute of Industrial Technology (KIIT) Deemed to Be University, Bhubaneswar, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jyotirmayee","family":"Dey","sequence":"additional","affiliation":[{"name":"School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT) Deemed to be University, Bhubaneswar, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soumya Ranjan","family":"Mahapatra","sequence":"additional","affiliation":[{"name":"School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT) Deemed to be University, Bhubaneswar, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arpan","family":"Ghosh","sequence":"additional","affiliation":[{"name":"School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT) Deemed to be University, Bhubaneswar, India."},{"name":"KIIT-Technology Business Incubator (KIIT-TBI), Kalinga Institute of Industrial Technology (KIIT) Deemed to be University, Bhubaneswar, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aryan","family":"Jaiswal","sequence":"additional","affiliation":[{"name":"KIIT-Technology Business Incubator (KIIT-TBI), Kalinga Institute of Industrial Technology (KIIT) Deemed to be University, Bhubaneswar, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santwana","family":"Padhi","sequence":"additional","affiliation":[{"name":"KIIT-Technology Business Incubator (KIIT-TBI), Kalinga Institute of Industrial Technology (KIIT) Deemed to be University, Bhubaneswar, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samudyata C.","family":"Prabhuswamimath","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Bioinformatics, School of Life Sciences, JSS Academy of Higher Education and Research, Mysuru, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1813-6478","authenticated-orcid":false,"given":"Namrata","family":"Misra","sequence":"additional","affiliation":[{"name":"School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT) Deemed to be University, Bhubaneswar, India."},{"name":"KIIT-Technology Business Incubator (KIIT-TBI), Kalinga Institute of Industrial Technology (KIIT) Deemed to be University, Bhubaneswar, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mrutyunjay","family":"Suar","sequence":"additional","affiliation":[{"name":"School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT) Deemed to be University, Bhubaneswar, India."},{"name":"KIIT-Technology Business Incubator (KIIT-TBI), Kalinga Institute of Industrial Technology (KIIT) Deemed to be University, Bhubaneswar, India."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,9,7]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21155211"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3RA47370H"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13020206"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2022.0045"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000003925"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10143"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/17435390.2015.1054908"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coelec.2020.08.011"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.2565"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.200902384"},{"key":"e_1_3_4_12_1","doi-asserted-by":"crossref","unstructured":"Bawa R Audette GF Rubinstein I. Handbook of Clinical Nanomedicine: Nanoparticles Imaging Therapy and Clinical Applications (Vol. 1). CRC Press; 2016.","DOI":"10.1201\/b19915"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10311-020-01022-9"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2015.11.011"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat5053"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-020-00685-4"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c02540"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c04006"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30211-7"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40475-020-00201-6"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11051-013-1634-1"},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c07197"},{"key":"e_1_3_4_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2009.08.003"},{"key":"e_1_3_4_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.porgcoat.2019.105381"},{"issue":"42","key":"e_1_3_4_25_1","first-page":"6221","article-title":"Exploring Klebsiella pneumoniae capsule polysaccharide proteins to design multiepitope subunit vaccine to fight against pneumonia","volume":"39","author":"Dey J","year":"2022","unstructured":"Dey J, , Mahapatra SR, , Lata S, et al. Exploring Klebsiella pneumoniae capsule polysaccharide proteins to design multiepitope subunit vaccine to fight against pneumonia. Expert Rev Vaccines, 2022; 39(42):6221\u20136237; doi: 10.1080\/14760584.2022.2021882.","journal-title":"Expert Rev Vaccines"},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2021.105171"},{"key":"e_1_3_4_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaz5466"},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/1556-276X-9-393"},{"key":"e_1_3_4_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2020.1758791"},{"issue":"1","key":"e_1_3_4_30_1","first-page":"1","article-title":"Preparation and antimicrobial activity of ZnO-NPs coated cotton\/starch and their functionalized ZnO-Ag\/cotton and Zn (II) curcumin\/cotton materials","volume":"10","author":"El-Nahhal IM","year":"2020","unstructured":"El-Nahhal IM, , Salem J, , Anbar R, et al. Preparation and antimicrobial activity of ZnO-NPs coated cotton\/starch and their functionalized ZnO-Ag\/cotton and Zn (II) curcumin\/cotton materials. Sci Rep, 2020; 10(1):1\u201310; doi: 10.1038\/s41598-020-61306-6.","journal-title":"Sci Rep"},{"key":"e_1_3_4_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.03.012"},{"key":"e_1_3_4_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules16108894"},{"key":"e_1_3_4_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0402486101"},{"key":"e_1_3_4_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408363.2021.1884640"},{"key":"e_1_3_4_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-43817-z"},{"key":"e_1_3_4_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2021.110515"},{"key":"e_1_3_4_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2020.04.015"},{"key":"e_1_3_4_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41232-020-00146-3"},{"key":"e_1_3_4_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13205-017-0741-6"},{"key":"e_1_3_4_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-020-02958-1"},{"key":"e_1_3_4_41_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2116044"},{"key":"e_1_3_4_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2020.09.018"},{"key":"e_1_3_4_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.infpip.2020.100044"},{"key":"e_1_3_4_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117627"},{"key":"e_1_3_4_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25928"},{"key":"e_1_3_4_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2020.105950"},{"key":"e_1_3_4_47_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2026920"},{"key":"e_1_3_4_48_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2020.1753577"},{"key":"e_1_3_4_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2014.07.022"},{"key":"e_1_3_4_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm9013364"},{"key":"e_1_3_4_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens9050359"},{"key":"e_1_3_4_52_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaw1565"},{"key":"e_1_3_4_53_1","doi-asserted-by":"publisher","DOI":"10.3109\/10717544.2014.920431"},{"key":"e_1_3_4_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ces.2014.08.046"},{"key":"e_1_3_4_55_1","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2020.1821583"},{"key":"e_1_3_4_56_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b15032"},{"key":"e_1_3_4_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2014.09.008"},{"key":"e_1_3_4_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2021.09.025"},{"key":"e_1_3_4_59_1","doi-asserted-by":"publisher","DOI":"10.2174\/157341311795542453"},{"key":"e_1_3_4_60_1","doi-asserted-by":"publisher","DOI":"10.4155\/tde-2020-0069"},{"key":"e_1_3_4_61_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym3031377"},{"key":"e_1_3_4_62_1","doi-asserted-by":"publisher","DOI":"10.1358\/mf.2005.27.2.876286"},{"key":"e_1_3_4_63_1","doi-asserted-by":"publisher","DOI":"10.2486\/indhealth.2018-0197"},{"key":"e_1_3_4_64_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsos.171113"},{"key":"e_1_3_4_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30628-0"},{"key":"e_1_3_4_66_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23092205"},{"key":"e_1_3_4_67_1","doi-asserted-by":"publisher","DOI":"10.4103\/0975-7406.72127"},{"key":"e_1_3_4_68_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c03822"},{"key":"e_1_3_4_69_1","doi-asserted-by":"publisher","DOI":"10.15171\/apb.2015.043"},{"key":"e_1_3_4_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.04.001"},{"key":"e_1_3_4_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2018.04.022"},{"key":"e_1_3_4_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110708"},{"key":"e_1_3_4_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2020.03.006"},{"key":"e_1_3_4_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2021.02.010"},{"key":"e_1_3_4_75_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1MA00541C"},{"key":"e_1_3_4_76_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-018-0392-8"},{"key":"e_1_3_4_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119428"},{"key":"e_1_3_4_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-021-00163-y"},{"key":"e_1_3_4_79_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21145126"},{"key":"e_1_3_4_80_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-020-01581-z"},{"key":"e_1_3_4_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-021-00311-w"},{"key":"e_1_3_4_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173751"},{"key":"e_1_3_4_83_1","doi-asserted-by":"publisher","DOI":"10.1177\/1060028017728294"},{"key":"e_1_3_4_84_1","article-title":"Clinical characterisation of eleven lateral flow assays for detection of COVID-19 antibodies in a population","author":"Rudolf F","year":"2020","unstructured":"Rudolf F, , Kaltenbach HM, , Linnik J, et al. Clinical characterisation of eleven lateral flow assays for detection of COVID-19 antibodies in a population. MedRxiv, 2020; doi: 10.1101\/2020.08.18.20177204.","journal-title":"MedRxiv"},{"key":"e_1_3_4_85_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano10081566"},{"key":"e_1_3_4_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2015.330"},{"key":"e_1_3_4_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117652"},{"key":"e_1_3_4_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13940-6"},{"key":"e_1_3_4_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijtb.2020.07.034"},{"key":"e_1_3_4_90_1","doi-asserted-by":"publisher","DOI":"10.1177\/2049936117713593"},{"key":"e_1_3_4_91_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm-2021-0004"},{"key":"e_1_3_4_92_1","doi-asserted-by":"publisher","DOI":"10.1177\/2042098618769568"},{"key":"e_1_3_4_93_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-014-1572-3"},{"key":"e_1_3_4_94_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-020-05190-5"},{"key":"e_1_3_4_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2018.07.096"},{"key":"e_1_3_4_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2010.07.001"},{"key":"e_1_3_4_97_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12090837"},{"key":"e_1_3_4_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2020.04.002"},{"key":"e_1_3_4_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20653-8"},{"key":"e_1_3_4_100_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1632"},{"key":"e_1_3_4_101_1","doi-asserted-by":"publisher","DOI":"10.1088\/2043-6262\/4\/4\/045013"},{"issue":"9","key":"e_1_3_4_102_1","first-page":"142","article-title":"Dendrimers and their applications as novel drug delivery carriers","volume":"3","author":"Tripathy S","year":"2013","unstructured":"Tripathy S, , Das MK. Dendrimers and their applications as novel drug delivery carriers. J Appl Pharm Sci, 2013; 3(9):142\u2013149. doi: 10.7324\/JAPS.2013.3924.","journal-title":"J Appl Pharm Sci"},{"key":"e_1_3_4_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/pola.26410"},{"key":"e_1_3_4_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.36"},{"key":"e_1_3_4_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03470-x"},{"key":"e_1_3_4_106_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12020102"},{"key":"e_1_3_4_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.058"},{"key":"e_1_3_4_108_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12274-017-1858-y"},{"key":"e_1_3_4_109_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abc1931"},{"key":"e_1_3_4_110_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2013.00140"},{"issue":"2","key":"e_1_3_4_111_1","first-page":"18","article-title":"Inhibition of SARS-CoV-2 replication by acidizing and RNA lyase-modified carbon nanotubes combined with photodynamic thermal effect","volume":"5","author":"Yang J.","year":"2020","unstructured":"Yang J. Inhibition of SARS-CoV-2 replication by acidizing and RNA lyase-modified carbon nanotubes combined with photodynamic thermal effect. J Explor Res Pharmacol, 2020; 5(2):18\u201323; doi: 10.14218\/JERP.2020.00005.","journal-title":"J Explor Res Pharmacol"},{"key":"e_1_3_4_112_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano11082129"},{"key":"e_1_3_4_113_1","doi-asserted-by":"publisher","DOI":"10.1002\/adtp.201800054"},{"key":"e_1_3_4_114_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1910113117"},{"key":"e_1_3_4_115_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5b08176"},{"key":"e_1_3_4_116_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/hvaa102"},{"key":"e_1_3_4_117_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c02250"}],"container-title":["OMICS: A Journal of Integrative Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/omi.2022.0072","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/omi.2022.0072","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/omi.2022.0072","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:05:41Z","timestamp":1777676741000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/omi.2022.0072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":116,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1089\/omi.2022.0072"],"URL":"https:\/\/doi.org\/10.1089\/omi.2022.0072","relation":{},"ISSN":["1536-2310","1557-8100"],"issn-type":[{"value":"1536-2310","type":"print"},{"value":"1557-8100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9]]}}}