{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:56:13Z","timestamp":1777928173941,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["OMICS: A Journal of Integrative Biology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>\n                    Tuberculosis (TB) among patients with human immunodeficiency virus (HIV) is a major global health burden and contributes to a high mortality rate due to HIV-mediated immunosuppression and subsequent susceptibility to TB. It is imperative to understand the pathogenesis of the association between HIV and TB for therapeutic innovation and preventive medicine. In the present study, we employed transcriptomic and bioinformatic analyses of differential gene expression data obtained from Gene Expression Omnibus (GEO) of the National Center for Biotechnology Information. The expression data of\n                    <jats:italic toggle=\"yes\">Mycobacterium tuberculosis<\/jats:italic>\n                    -infected macrophages and blood samples from TB patients (GSE54992, GSE52819, and GSE19435) and blood samples from HIV patients (GSE30310) were accessed for identification of differentially expressed genes (DEGs). Data from 20 healthy subjects and 19 patients with TB and 16 healthy subjects and 16 patients with HIV were analyzed. We report here the DEGs shared by HIV and TB infection. Moreover, HIV and TB host\u2013pathogen interaction data were collected from BIOGRID, v 4.4.210, for identifying significantly modulated genes' targets and their interactions with the host. Host targets, including\n                    <jats:italic toggle=\"yes\">PLSCR1<\/jats:italic>\n                    (phospholipid scramblase 1),\n                    <jats:italic toggle=\"yes\">STAT1<\/jats:italic>\n                    (signal transducer and activator of transcription-1 alpha\/beta),\n                    <jats:italic toggle=\"yes\">FBXO6<\/jats:italic>\n                    (F-box only protein 6),\n                    <jats:italic toggle=\"yes\">ITGAL<\/jats:italic>\n                    (integrin alpha-L), and\n                    <jats:italic toggle=\"yes\">APP<\/jats:italic>\n                    (amyloid beta precursor protein), are commonly modulated in both diseases. The function of these targets was screened from and reconciled with the literature to understand their role in the pathogenesis of HIV and TB. Overall, the study results suggest that these targets may potentially be important contributors to the pathogenesis of this comorbidity. Further experimental work is needed for evaluating these new observations, with a view to future therapeutic innovation for patients with HIV and TB.\n                  <\/jats:p>","DOI":"10.1089\/omi.2022.0130","type":"journal-article","created":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T10:33:55Z","timestamp":1673951635000},"page":"15-23","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Pathogenesis of Human Immunodeficiency Virus and\n                    <i>Mycobacterium tuberculosis<\/i>\n                    Infection as Revealed by Transcriptome and Interactome Data"],"prefix":"10.1177","volume":"27","author":[{"given":"Pooja","family":"Wakchoure","sequence":"first","affiliation":[{"name":"Division of Microbiology, ICMR\u2013National AIDS Research Institute, Pune, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khizra","family":"Momin","sequence":"additional","affiliation":[{"name":"Division of Microbiology, ICMR\u2013National AIDS Research Institute, Pune, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8748-1841","authenticated-orcid":false,"given":"Abdul Arif","family":"Khan","sequence":"additional","affiliation":[{"name":"Division of Microbiology, ICMR\u2013National AIDS Research Institute, Pune, India."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,1,17]]},"reference":[{"key":"e_1_3_5_2_1","doi-asserted-by":"crossref","first-page":"D991","DOI":"10.1093\/nar\/gks1193","article-title":"NCBI GEO: Archive for functional genomics data sets\u2014Update","volume":"41","author":"Barrett T","year":"2013","unstructured":"Barrett T, , Wilhite SE, , Ledoux P, et al. NCBI GEO: Archive for functional genomics data sets\u2014Update. Nucleic Acids Res, 2013; 41(Database):D991\u2013D995; doi: 10.1093\/nar\/gks1193","journal-title":"Nucleic Acids Res"},{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2017.128"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1023"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a017871"},{"key":"e_1_3_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01795-8"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09955-8"},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1801557"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/30.1.207"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/20477724.2017.1351080"},{"key":"e_1_3_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199011000-00006"},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2018.03.006"},{"key":"e_1_3_5_13_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.8.4914"},{"key":"e_1_3_5_14_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-171133"},{"key":"e_1_3_5_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.14.9134-9144.2005"},{"key":"e_1_3_5_16_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-829520"},{"key":"e_1_3_5_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00426"},{"key":"e_1_3_5_18_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.51248"},{"key":"e_1_3_5_19_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.48.30864"},{"key":"e_1_3_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2013.02.098"},{"key":"e_1_3_5_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/09564624211065232"},{"key":"e_1_3_5_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753425918803674"},{"key":"e_1_3_5_23_1","first-page":"117","article-title":"Quality of life of people living with HIV and AIDS and antiretroviral therapy","volume":"4","author":"Oguntibeju OO","year":"2012","unstructured":"Oguntibeju OO. Quality of life of people living with HIV and AIDS and antiretroviral therapy. HIV AIDS (Auckl), 2012; 4:117\u2013124; doi: 10.2147\/HIV.S32321","journal-title":"HIV AIDS (Auckl)"},{"key":"e_1_3_5_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.3978"},{"key":"e_1_3_5_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep43725"},{"key":"e_1_3_5_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41540-017-0005-4"},{"key":"e_1_3_5_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199808000-00011"},{"key":"e_1_3_5_28_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a017863"},{"key":"e_1_3_5_29_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1239303"},{"key":"e_1_3_5_30_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7695364"},{"key":"e_1_3_5_31_1","first-page":"9","article-title":"Drug-resistant tuberculosis and HIV infection: Current perspectives","volume":"12","author":"Singh A","year":"2020","unstructured":"Singh A, , Prasad R, , Balasubramanian V, et al. Drug-resistant tuberculosis and HIV infection: Current perspectives. HIV AIDS (Auckl), 2020; 12:9\u201331; doi: 10.2147\/HIV.S193059","journal-title":"HIV AIDS (Auckl)"},{"key":"e_1_3_5_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028125"},{"key":"e_1_3_5_33_1","unstructured":"The Joint United Nations Programme on HIV\/AIDS (UNAIDS). UNAIDS Fact Sheet 2022. Geneva Switzerland; 2022a. Available from: https:\/\/www.unaids.org\/sites\/default\/files\/media_asset\/UNAIDS_FactSheet_en.pdf [Last accessed: November 9 2022]."},{"key":"e_1_3_5_34_1","unstructured":"The Joint United Nations Programme on HIV\/AIDS (UNAIDS). UNAIDS Fact Sheet\u2014World Tuberculosis Day 2022 2022b. Available from: https:\/\/www.unaids.org\/sites\/default\/files\/media_asset\/20220324_TB_FactSheet_en.pdf [Last accessed: November 9 2022]."},{"key":"e_1_3_5_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1915-7"},{"key":"e_1_3_5_36_1","unstructured":"Waymack JR Sundareshan V Acquired Immune Deficiency Syndrome. Updated September 5 2022. StatPearls Publishing: Treasure Island FL; 2022."},{"key":"e_1_3_5_37_1","unstructured":"World Health Organization (WHO). Global Tuberculosis Report 2021. 2021. Available from: https:\/\/www.who.int\/publications\/i\/item\/9789240037021 [Last accessed: November 9 2022]."},{"key":"e_1_3_5_38_1","unstructured":"World Health Organization (WHO). Tuberculosis. 2022. Available from: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/tuberculosis [Last accessed: November 9 2022]."},{"key":"e_1_3_5_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.14856"},{"key":"e_1_3_5_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2008.10.004"}],"container-title":["OMICS: A Journal of Integrative Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/omi.2022.0130","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/omi.2022.0130","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/omi.2022.0130","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:05:56Z","timestamp":1777676756000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/omi.2022.0130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1089\/omi.2022.0130"],"URL":"https:\/\/doi.org\/10.1089\/omi.2022.0130","relation":{},"ISSN":["1536-2310","1557-8100"],"issn-type":[{"value":"1536-2310","type":"print"},{"value":"1557-8100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]}}}