{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:56:23Z","timestamp":1777928183658,"version":"3.51.4"},"reference-count":54,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["OMICS: A Journal of Integrative Biology"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:p>\n                    Foot ulcers and associated infections significantly contribute to morbidity and mortality in diabetes. While diverse pathogens are found in the diabetes-related infected ulcers,\n                    <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                    remains one of the most virulent and widely prevalent pathogens. The high prevalence of\n                    <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                    in chronic wound infections, especially in clinical settings, is attributed to its ability to evolve and acquire resistance against common antibiotics and to elicit an array of virulence factors. In this study, whole genome comparison of four strains of\n                    <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                    (MUF168, MUF256, MUM270, and MUM475) isolated from diabetic foot ulcer (DFU) infections showing varying resistance patterns was carried out to study the genomic similarity, antibiotic resistance profiling, associated virulence factors, and sequence variations in drug targets. The comparative genome analysis showed strains MUM475 and MUM270 to be highly resistant, MUF256 with moderate levels of resistance, and MUF168 to be the least resistant. Strain MUF256 and MUM475 harbored more virulence factors compared with other two strains. Deleterious sequence variants were observed suggesting potential role in altering drug targets and drug efficacy. This comparative whole genome study offers new molecular insights that may potentially inform evidence-based diagnosis and treatment of DFUs in the clinic.\n                  <\/jats:p>","DOI":"10.1089\/omi.2022.0184","type":"journal-article","created":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T16:16:19Z","timestamp":1675872979000},"page":"51-61","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["How Can Omics Inform Diabetic Foot Ulcer Clinical Management? A Whole Genome Comparison of Four Clinical Strains of\n                    <i>Staphylococcus aureus<\/i>"],"prefix":"10.1177","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1578-5448","authenticated-orcid":false,"given":"Ankit Singh","family":"Tanwar","sequence":"first","affiliation":[{"name":"Department of Public Health Genomics, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, India."},{"name":"United Nations University\u2013Maastricht Economic and Social Research Institute on Innovation and Technology (UNU-MERIT), Maastricht, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Padival","family":"Shruptha","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7212-1886","authenticated-orcid":false,"given":"Bobby","family":"Paul","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, and Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thokur Sreepathy","family":"Murali","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0685-5432","authenticated-orcid":false,"given":"Angela","family":"Brand","sequence":"additional","affiliation":[{"name":"Department of Public Health Genomics, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, India."},{"name":"United Nations University\u2013Maastricht Economic and Social Research Institute on Innovation and Technology (UNU-MERIT), Maastricht, The Netherlands."},{"name":"Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2368-5490","authenticated-orcid":false,"given":"Kapaettu","family":"Satyamoorthy","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, India."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,2,16]]},"reference":[{"issue":"1","key":"e_1_3_6_2_1","first-page":"D517","article-title":"CARD 2020: Antibiotic resistome surveillance with the comprehensive antibiotic resistance database","volume":"48","author":"Alcock BP","year":"2020","unstructured":"Alcock BP, , Raphenya AR, , Lau TTY, et al. 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