{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:56:57Z","timestamp":1777928217092,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["OMICS: A Journal of Integrative Biology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:p>\n                    Liver cirrhosis is a severe chronic disease that results from various etiological factors and leads to substantial morbidity and mortality. Alcoholic cirrhosis (AC) and non-AC (NAC) arise from prolonged and excessive consumption of alcohol and metabolic syndromes, respectively. Precise molecular mechanisms of AC and NAC are yet to be comprehensively understood for diagnostics and therapeutic advances to materialize. This study reports novel findings to this end by utilizing high-throughput RNA sequencing and microarray data from the Gene Expression Omnibus (GEO). We performed a meta-analysis of transcriptomics data to identify the differentially expressed genes specific to AC and NAC. Functional enrichment and protein\u2013protein interaction network analyses uncovered novel hub genes and transcription factors (TFs) critical to AC and NAC. We found that AC is primarily driven by metabolic dysregulation and oxidative stress, with key TFs such as RELA, NFKB1, and STAT3. NAC was characterized by fibrosis and tissue remodeling associated with metabolic dysfunction, with TFs including USF1, MYCN, and HIF1A. Key hub genes such as\n                    <jats:italic toggle=\"yes\">ESR1<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">JUN<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">FOS<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">PKM<\/jats:italic>\n                    in AC, and\n                    <jats:italic toggle=\"yes\">CD8A<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">MAPK3<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">CCND1<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">CXCR4<\/jats:italic>\n                    in NAC were identified, along with their associated TFs, pointing to potential therapeutic targets. Our results underscore the unique and shared molecular mechanisms that underlie AC and NAC and inform the efforts toward precision medicine and improved patient outcomes in liver cirrhosis.\n                  <\/jats:p>","DOI":"10.1089\/omi.2024.0168","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T04:54:54Z","timestamp":1729140894000},"page":"537-547","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Unique and Shared Molecular Mechanisms of Alcoholic and Non-Alcoholic Liver Cirrhosis Identified Through Transcriptomics Data Integration"],"prefix":"10.1177","volume":"28","author":[{"given":"Ki-Hoon","family":"Park","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, College of Medicine, Kosin University, Busan, South Korea."},{"name":"Department of Anatomy and Neurobiology, College of Medicine, Kyung Hee University, Dongdaemun-gu, South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hwajin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, Graduation School, Kyung Hee University, Dongdaemun-gu, South Korea."},{"name":"Department of Precision Medicine, College of Medicine, Kyung Hee University, Dongdaemun-gu, South Korea."},{"name":"Department of Biochemistry and Molecular Biology, College of Medicine, Kyung Hee University, Dongdaemun-gu, South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Hyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, Graduation School, Kyung Hee University, Dongdaemun-gu, South Korea."},{"name":"Department of Precision Medicine, College of Medicine, Kyung Hee University, Dongdaemun-gu, South Korea."},{"name":"Department of Clinical Pharmacology and Therapeutics, College of Medicine, Kyung Hee University, Dongdaemun-gu, South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Keon","family":"Yon","sequence":"additional","affiliation":[{"name":"Department of Precision Medicine, College of Medicine, Kyung Hee University, Dongdaemun-gu, South Korea."},{"name":"Department of Digital Health, College of Medicine, Kyung Hee University, Dongdaemun-gu, South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Il","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Surgery, College of Medicine, Kosin University, Busan, South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyung-Joo","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, College of Medicine, Kosin University, Busan, South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3946-5406","authenticated-orcid":false,"given":"Junyang","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology, College of Medicine, Kyung Hee University, Dongdaemun-gu, South Korea."},{"name":"Department of Biomedical Science, Graduation School, Kyung Hee University, Dongdaemun-gu, South Korea."},{"name":"Department of Precision Medicine, College of Medicine, Kyung Hee University, Dongdaemun-gu, South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2130-4719","authenticated-orcid":false,"given":"Na Young","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, College of Medicine, Dong-A University, Busan, South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,11,6]]},"reference":[{"key":"e_1_3_7_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-4-2"},{"key":"e_1_3_7_3_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20160935"},{"key":"e_1_3_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2024.105691"},{"key":"e_1_3_7_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15102323"},{"key":"e_1_3_7_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007380"},{"key":"e_1_3_7_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1266527"},{"key":"e_1_3_7_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2017.00311"},{"key":"e_1_3_7_9_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.304576"},{"key":"e_1_3_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/30.1.207"},{"key":"e_1_3_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.03.039"},{"key":"e_1_3_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1132"},{"key":"e_1_3_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23050"},{"key":"e_1_3_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1013"},{"issue":"12","key":"e_1_3_7_15_1","first-page":"3810","article-title":"Hypoxia promotes fibrogenesis in\u00a0vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition","volume":"117","author":"Higgins DF","year":"2007","unstructured":"Higgins DF, , Kimura K, , Bernhardt WM, et al. Hypoxia promotes fibrogenesis in\u00a0vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition. J Clin Invest, 2007; 117(12):3810\u20133820; doi: 10.1172\/JCI30487","journal-title":"J Clin Invest"},{"key":"e_1_3_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780090710"},{"key":"e_1_3_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-023-00759-2"},{"key":"e_1_3_7_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22115717"},{"key":"e_1_3_7_19_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm-20-2948"},{"key":"e_1_3_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.12.003"},{"key":"e_1_3_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2016.06.011"},{"key":"e_1_3_7_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/HC9.0000000000000026"},{"key":"e_1_3_7_23_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i21.6457"},{"key":"e_1_3_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/sigtrans.2017.23"},{"key":"e_1_3_7_25_1","doi-asserted-by":"publisher","DOI":"10.35946\/arcr.v37.2.08"},{"key":"e_1_3_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2021.05.015"},{"key":"e_1_3_7_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv007"},{"key":"e_1_3_7_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.270.5235.467"},{"key":"e_1_3_7_29_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1239303"},{"key":"e_1_3_7_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"e_1_3_7_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac1000"},{"key":"e_1_3_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.13764"},{"key":"e_1_3_7_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2484"},{"key":"e_1_3_7_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03443-y"},{"key":"e_1_3_7_35_1","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2011.0118"},{"key":"e_1_3_7_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09234-6"}],"container-title":["OMICS: A Journal of Integrative Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/omi.2024.0168","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/omi.2024.0168","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/omi.2024.0168","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:07:17Z","timestamp":1777676837000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/omi.2024.0168"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":35,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1089\/omi.2024.0168"],"URL":"https:\/\/doi.org\/10.1089\/omi.2024.0168","relation":{},"ISSN":["1536-2310","1557-8100"],"issn-type":[{"value":"1536-2310","type":"print"},{"value":"1557-8100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11]]}}}